The multifaceted roles of macrophages in the transition from hepatitis to hepatocellular carcinoma: From mechanisms to therapeutic strategies
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease,
Год журнала:
2025,
Номер
1871(3), С. 167676 - 167676
Опубликована: Янв. 18, 2025
Язык: Английский
Short-Term Fasting Induces Hepatocytes’ Stress Response and Increases Their Resilience
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 999 - 999
Опубликована: Янв. 24, 2025
Fasting
leads
to
a
range
of
metabolic
adaptations
that
have
developed
through
evolution,
as
humans
and
other
mammals
unequal
access
food
over
the
circadian
cycle
are
therefore
adapted
fasting
feeding
cycles.
We
investigated
role
single
episode
in
rats
triggering
stress
response
liver
hepatocytes.
Since
responses
were
observed
both
animals
isolated
cells,
we
whether
effects
animal
stressor
could
persist
cells
after
isolation.
By
measuring
staurosporine-induced
apoptosis,
signalling,
oxidative
antioxidant
hepatocytes
from
fasted
ad
libitum-fed
animals,
found
only
elicited
prevented
caspase-9
activation
persisted
cells.
The
addition
glucose
oxidase,
hydrogen
peroxide-producing
enzyme,
also
led
phenotype
caspase-9.
A
thus
normal
hepatocytes,
with
peroxide
second
messenger
reduces
initiation
apoptosis.
This
finding
is
first
characterisation
mechanism
underlying
provides
basis
for
development
methods
increase
resilience
These
findings
need
be
taken
into
account
when
interpreting
results
obtained
cell
research
models
overnight
used
many
laboratory
protocols.
form
clinical
applications
resistance
transplants
improve
fitness
under
acute
conditions
some
diseases.
Язык: Английский
Glutathionylation and Metabolic Dysfunction-associated Steatotic Liver Disease
Biochimie,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Spinach ameliorates dietary oxidized tallow-induced NAFLD by regulating inflammatory cytokines, peroxisome proliferator-activated receptors, and antioxidant systems
Phytomedicine Plus,
Год журнала:
2024,
Номер
unknown, С. 100722 - 100722
Опубликована: Дек. 1, 2024
Язык: Английский