Frontiers in Aging Neuroscience, Год журнала: 2024, Номер 16

Опубликована: Ноя. 25, 2024

Clinical symptoms of Parkinson’s disease (PD) are classified into motor and non-motor symptoms. Mental disorders, especially depression, one the major manifestations PD. However, underlying mechanisms remain poorly understood. In present study, 21 neurotransmitters associated with mental disorders were measured in serum samples from patients controls using ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) assay. Additionally, five clinical scales—the MDS Unified Disease Rating Scale (UPDRS), Non-Motor Symptoms (NMSS), Mini-Mental State Examination (MMSE), Hamilton Anxiety (HAMA), Depression (HAMD)—were used to evaluate severity both PD patients. Analysis neurotransmitter metabolism revealed significant changes tryptophan (Trp) metabolic pathway Specifically, levels Trp, kynurenine (KYN), kynurenic acid (KA), nicotinamide (NAM), 5-methoxyltryptamine (MeOTA) substantially decreased. three other excitation/inhibiting amino acids—glutamic (Glu), 4-aminobutyric (GABA), aspartic (Asp)—also declined. Moreover, conversion ratios, such as KA/KYN, nicotinamide/niacin (NAM/NA), 5-hydroxytryptophan/tryptophan (5-HTP/Trp), quinolinic acid/kynurenic (QA/KA), provided more dynamic insights disrupted metabolism. Correlation analyses between scale scores showed that concentrations xanthurenic (XA) turnover rate 3-hydroxykynurenine (3-HK) negatively correlated UPDRS scores, while 5-hydroxytryptamine (5-HT) GABA summary, this study elucidates, for first time, potential association dynamics altered etiology terms functions. These findings offer novel biomarkers therapeutic targets treatment

Язык: Английский