Rodent Models of Diabetic Neuropathy, Role of Calcium Homeostasis in Pain and KB-R7943 as a Potential Therapeutic

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 2094 - 2094

Опубликована: Фев. 27, 2025

Diabetic neuropathy (DN) is characterized by nerve damage as a consequence of diabetes mellitus. Diabetes causes high blood glucose and triglyceride levels, which destroy the vessels over time trigger DN. Peripheral most common type DN, encompasses broad range symptoms. One fourth patients with suffer from neuropathic pain, decreases their quality life puts them at risk for emotional disturbances depression. Finding an adequate therapy essential element in cure painful DN (PDN). Since pathophysiology this disease still needs to be elucidated, has led development various vivo diabetic models. Animal models not only provide insights into but also are significant drivers treatment assessment improvement. In review, we present major features commonly used chemically diet-induced PDN rodents progress date, utilized better understanding mechanism finding novel therapeutics. Considering role Ca2+ homeostasis review our recent research data on Na+/Ca2+ exchanger blocker KB-R7943, potential pain reliever rodent model

Язык: Английский

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Effect of Resveratrol and Quercetin on SFRP4 as a Biomarker of Diabesity: In Silico and In Vivo Studies

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер unknown, С. 151748 - 151748

Опубликована: Апрель 1, 2025

Язык: Английский

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Effect of exercise training on glycemic control in diabetic peripheral neuropathy: A GRADE assessed systematic review and meta-analysis of randomized-controlled trials

Primary care diabetes, Год журнала: 2024, Номер 18(2), С. 109 - 118

Опубликована: Янв. 28, 2024

Язык: Английский

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The Safety and Efficacy of Stem Cell Therapy for Diabetic Peripheral Neuropathy in Animal Studies: A Systematic Review and Meta-Analysis

Опубликована: Янв. 1, 2024

Background: Diabetes mellitus results in end-organ injury such as diabetic neuropathy which has a significant impact on patients' quality of life. The present study aimed to evaluate the safety and efficacy utilizing stem cell therapy for peripheral (DPN).Methods: A systematic search MEDLINE, Embase, Scopus, Web Science, Cochrane Central Register Controlled Trials was performed. time period from inception January 31, 2024, with no language restrictions. All animal studies investigating treating DPN were included. random-effects model combine effect sizes our meta-analysis applied.Findings: 29 out 5431 records met eligibility criteria. In these studies, improved motor sensory nerve conduction velocity, compound muscle action potential (CMAP), sciatic blood flow. Post-treatment, mechanical thermal nociceptive thresholds decreased. Rats had improvement axonal circularity, growth factor, transforming factor beta 1; mice increased weight, CMAP, angiopoietin 1. subgroup showed that dental pulp cells greatest effects across all parameters, while bone marrow mononuclear strong biochemical responses.Interpretation: Stem demonstrates promising ameliorating neuropathic symptoms models. Human patient targeted treatment procedures specific disorders are advocated improve therapeutic outcomes.Funding: This work funded by Tehran University Medical Sciences grant number 1402-1-93-65474.Declaration Interest: authors declare they have competing interests.Ethical Approval: he Ethics Committee approved study, reference is IR.TUMS.SINAHOSPITAL.REC.1402.052.

Язык: Английский

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The safety and efficacy of stem cell therapy for diabetic peripheral neuropathy in animal studies: A systematic review and meta-analysis

Neuroscience, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

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