Eco-friendly and high-performance extraction of flavonoids from lemon peel wastes by applying ultrasound-assisted extraction and eutectic solvents
Sustainable Chemistry and Pharmacy,
Год журнала:
2024,
Номер
39, С. 101558 - 101558
Опубликована: Апрель 3, 2024
Язык: Английский
Phytochemical analysis of Stachys iva: Discovering the optimal extract conditions and its bioactive compounds
Open Life Sciences,
Год журнала:
2025,
Номер
20(1)
Опубликована: Янв. 1, 2025
The
Lamiaceae
family
is
one
of
the
widest
plant
families
among
Greek
flora,
consisting
a
great
variety
species,
with
genus
Stachys
being
its
largest
representatives,
spread
to
most
continents.
also
known
for
beneficial
properties
and
has
been
used
years
as
traditional
remedy
healing
various
health
conditions.
iva,
an
endemic
in
Kozani
Regional
unit,
consumed
infusion
by
locals
reported
relieve
common
cold
symptoms,
have
antimicrobial
properties,
contribute
normalizing
blood
glucose
levels.
present
study
aimed
identify
chemical
compounds
(such
phenolic
acids,
flavonoids,
phenylethanoid
glycosides)
responsible
herb's
pharmacological
determine
optimal
extraction
conditions
gather
extract
high
therapeutic
value
without
solvent
energy
waste.
Experiments
conducted
proved
that
extracting
simple
stirring
deionized
water
75
min
at
80°C
best
option.
In
contrast,
extract's
total
polyphenol
content
was
determined,
were
identified
high-performance
liquid
chromatography
analysis.
addition,
other
methods
utilized
(e.g.,
ferric-reducing
antioxidant
power
assay
2,2-diphenyl-1-picrylhydrazyl
antiradical
activity
assay)
reveal
potent
antioxidant,
anti-hydrogen
peroxide,
anti-inflammatory
activity,
while
correlation
between
these
examined.
Язык: Английский
Special Issue: “Recent Advances in Ion Channels and Ion Channelopathies”
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 3598 - 3598
Опубликована: Март 22, 2024
The
aim
of
this
special
issue
was
to
showcase
recent
advanced
in
understanding
ion
channel
function
and
dysfunction
associated
with
disease
[...]
Язык: Английский
Narirutin-Rich Celluclast Extract from Mandarin (Citrus unshiu) Peel Alleviates High-Fat Diet-Induced Obesity and Promotes Energy Metabolism in C57BL/6 Mice
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(8), С. 4475 - 4475
Опубликована: Апрель 19, 2024
Mandarin
peel,
a
main
by-product
from
the
processing
of
citrus
juice,
has
been
highlighted
for
its
various
bioactivities
and
functional
ingredients.
Our
previous
study
proved
inhibitory
effects
Celluclast
extract
mandarin
peel
(MPCE)
on
lipid
accumulation
differentiation
in
3T3-L1
adipocytes.
Therefore,
current
aimed
to
evaluate
anti-obesity
effect
MPCE
high-fat
diet
(HFD)-induced
obese
mice.
The
high-performance
liquid
chromatography
(HPLC)
analysis
exhibited
that
narirutin
hesperidin
are
active
components
MPCE.
results
showed
supplementation
decreased
adiposity
by
reducing
body
organ
weights
HFD-induced
also
reduced
triglyceride
(TG),
alanine
transaminase
(ALT),
aspartate
(AST),
leptin
contents
serum
HFD-fed
Moreover,
significantly
inhibited
hepatic
regulating
expression
levels
proteins
associated
with
metabolism,
including
sterol
regulatory
element-binding
protein
(SREBP1c),
fatty
acid
synthase
(FAS),
acetyl-CoA
carboxylase
(ACC).
Furthermore,
administration
both
adipogenesis
lipogenesis,
modulation
energy
metabolism
activating
5′
adenosine
monophosphate-activated
kinase
(AMPK)
lipolytic
enzymes
such
as
hormone-sensitive
lipase
(HSL)
white
adipose
tissue
(WAT).
Altogether,
our
findings
indicate
improves
obesity
can
be
used
curative
agent
pharmaceuticals
nutraceuticals
alleviate
related
disorders.
Язык: Английский
Therapeutic Potential of Quercetin in Diabetic Neuropathy and Retinopathy: Exploring Molecular Mechanisms
Current Topics in Medicinal Chemistry,
Год журнала:
2024,
Номер
24(27), С. 2351 - 2361
Опубликована: Авг. 28, 2024
:
Diabetes
mellitus
poses
a
significant
health
challenge
globally,
often
leading
to
debilitating
complications,
such
as
neuropathy
and
retinopathy.
Quercetin,
flavonoid
prevalent
in
fruits
vegetables,
has
demonstrated
potential
therapeutic
effects
these
conditions
due
its
antioxidant,
anti-inflammatory,
neuroprotective
properties.
This
review
summarizes
provides
comprehensive
understanding
of
the
molecular
mechanisms
underlying
efficacy
quercetin
ameliorating
diabetic
A
thorough
search
was
carried
out
across
scientific
databases,
SciFinder,
PubMed,
Google
Scholar,
gather
pertinent
literature
regarding
effect
on
retinopathy
till
February
2024.
Preclinical
studies
indicate
that
mitigates
neuropathic
pain,
sensory
deficits,
nerve
damage
associated
with
by
improving
neuronal
function,
reducing
DNA
damage,
regulating
pro-inflammatory
cytokines,
enhancing
antioxidant
enzyme
levels
endothelial
well
restoring
injuries.
In
retinopathy,
shows
preserve
retinal
structure
inhibiting
neovascularization,
preventing
cell
death,
increasing
neurotrophic
factor
levels.
Moreover,
through
modulating
key
signaling
pathways,
AMP-activated
Protein
Kinase
(AMPK)
activation,
Glucose
Transporter
4
(GLUT
4)
upregulation,
insulin
secretion
regulation,
demonstrates
oxidative
stress
inflammation,
thereby
protecting
tissues.
Despite
promising
preclinical
findings,
challenges,
limited
bioavailability,
necessitate
further
research
optimize
quercetin’s
clinical
application
order
establish
optimal
dosage,
formulation,
long-term
settings.
Язык: Английский