Anticancer properties of copolymer nanoparticles loaded with Feoniculum vulgare derivatives in Hs578T and SUM159 cancer cell lines
Abstract
Background
In
recent
years,
the
rising
occurrence
of
cancer,
particularly
breast
has
led
to
a
growing
interest
in
utilizing
nanotechnology
for
treatment.
As
result
significant
side
effects
chemical
drugs,
researchers
have
explored
potential
plants
with
antioxidant
properties
as
an
alternative
option.
Feoniculum
vulgare ,
one
potent
cancer
therapy,
is
rich
anti-cancer
compounds
found
its
essential
oil
and
ethanolic
extract.
Methods
This
study
was
conducted
investigate
anti-tumor
F.
along
application
copolymers
their
targeted
delivery
Hs578T
SUM159
cells.
First,
extract
from
aerial
parts
calluses
vulgare
extraction
were
produced.
Second,
polymer
nanoparticles
composed
PLA-Chitosan
synthesized,
characteristics
investigated
using
various
techniques
such
Hydrogen
nuclear
magnetic
resonance
spectroscopy
(1H-NMR),
Fourier
transform
infrared
(FTIR),
thermogravimetric
analysis.
After
preparation
PLA-PEG-HA/PLA-Chitosan
nanoparticles,
physicochemical
these
including
size,
zeta
potential,
morphology,
size
distribution,
features
evaluated.
The
encapsulation
efficiency
extract,
oil,
Anethole,
pure
quercetin
analyzed.
that
drug
release
kinetics
(at
pH
=
5
7.4),
in
vitro
cytotoxicity
evaluation,
analysis
cell
apoptosis
evaluate
efficacy
triple-negative
lines
Results
results
indicated
possess
spherical
shape
average
240
nm
-10.8
mV.
Moreover,
pattern
illustrated
higher
rate
synthesized
under
acidic
conditions
(pH
5).
WST-1
assay
revealed
biocompatibility
drug-free
nanocarriers
minimal
toxicity.
Additionally,
line
treated
PLA-PEG-HA/Chitosan-PLA/Quercetin
exhibited
highest
percentages
pre-
post-apoptotic
cells
(34.06%
8.19%,
respectively).
Conclusions
PLA-PEG-HA/Chitosan-PLA
copolymer
exhibit
noteworthy
capacity
Quercetin,
other
present
towards
cancerous
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Дек. 12, 2024
Язык: Английский
