This
study
investigates
lignin-based
bio-composites
incorporated
with
polyvinyl
alcohol
(PVA)
and
varying
concentrations
of
tea
tree
oil
to
assess
their
antibacterial
antifungal
properties.
Lignin,
a
complex
aromatic
polymer
an
intricate
three-dimensional
network,
is
enriched
conjugated
systems
oxygenated
functional
groups,
including
hydroxyl,
methoxy,
carbonyl
groups.
The
novel
exhibit
significant
antimicrobial
activity,
demonstrating
potent
efficacy
against
Escherichia
coli
Staphylococcus
aureus
as
well
notable
Detailed
characterization
through
FTIR
SEM
provides
critical
insights
into
the
structural
attributes
composite
films.
results
indicate
that
PVA-lignin
films
enhanced
show
superior
resistance
microbial
proliferation.
underscores
potential
these
in
applications
such
medical
devices,
packaging
materials,
environmental
protection,
addressing
increasing
demand
for
eco-friendly
alternatives.
BMC Infectious Diseases,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 26, 2024
The
extensively
drug-resistant
(XDR)
strains
of
Acinetobacter
baumannii
have
become
a
major
cause
nosocomial
infections,
increasing
morbidity
and
mortality
worldwide.
Many
different
treatments,
including
phage
therapy,
are
attractive
ways
to
overcome
the
challenges
antibiotic
resistance.
This
study
investigates
biofilm
formation
ability
30
XDR
A.
isolates
efficacy
cocktail
four
tempetate
bacteriophages
(SA1,
Eve,
Ftm,
Gln)
antibiotics
(ampicillin/sulbactam,
meropenem,
colistin)
in
inhibiting
degrading
biofilms
these
strains.
majority
(83.3%)
exhibited
strong
formation.
bacteriophage
showed
varying
degrees
effectiveness
against
biofilms,
with
higher
concentrations
generally
leading
more
significant
inhibition
degradation
rates.
antibiotics-bacteriophage
combinations
also
enhanced
biofilms.
findings
suggested
that
is
an
effective
tool
combating
its
depending
on
concentration.
Combining
improved
removal
indicating
promising
strategy
for
managing
infections.
These
results
contribute
our
understanding
dynamics
potential
cocktails
as
novel
therapeutic
approach
combat
antibiotic-resistant
bacteria.
Electrospinning
stands
out
as
a
highly
precise
method
for
producing
nanofibers,
offering
exceptional
control
over
their
morphology
by
adjusting
parameters,
making
it
the
preferred
choice
efficiently
tailoring
nanofiber
properties.
Nanofibers,
increasingly
recognized
possibilities
within
drug
delivery
systems
that
they
possess,
offer
distinctive
features
such
high
surface
area
(10
to
1000m2/g),
efficient
loading,
and
ability
provide
sustained
release.
Fabricating
nanofibers
from
biopolymers
is
particularly
favored
due
numerous
advantages
including
biocompatibility,
capacity
replicate
extracellular
matrix,
biodegradability,
non-cytotoxicity,
renewability,
them
option
other
polymers
various
applications.
In
this
regard,
review
thoroughly
emphasizes
drug-loaded
electrospun
diverse
applications
including,
wound
healing,
pesticide
release
matrices,
stent
coatings,
therapeutic
It
also
discusses
recent
progress
in
incorporation
into
fabrication
methods,
assessment
of
loading
release,
kinetics.
This
provides
insight
about
molecular
interactions
with
help
dynamics
providing
valuable
insights
can
elucidate
behavior
molecules
time,
allowing
researchers
investigate
dynamics,
stability
carriers,
between
drugs
targets
at
level
engineering
next-generation
systems.
Polymers,
Год журнала:
2024,
Номер
16(16), С. 2346 - 2346
Опубликована: Авг. 19, 2024
Silybin
is
a
natural
flavonolignan
with
potential
anticancer,
antioxidant,
and
hepatoprotective
properties.
In
the
present
study,
various
loadings
of
silybin
(1,
3,
5
wt%)
were
encapsulated
in
poly-ε-caprolactone
(PCL)
fibers
by
electrospinning,
order
to
produce
new
pharmaceutical
composites
improved
bioactive
drug
delivery
The
morphological
characteristics
composite
fibrous
structures
evaluated
scanning
electron
microscopy
(SEM),
encapsulation
efficiency
release
rate
quantified
using
UV-Vis
spectrophotometer.
analysis
membranes’
thermal
behavior
differential
calorimetry
(DSC)
thermogravimetric
(TGA)
revealed
existence
interaction
between
PCL
silybin.
An
investigation
cytocompatibility
membranes
that
normal
cells
displayed
an
unimpeded
proliferation
respective
concentrations;
however,
tumor
cell
growth
demonstrated
dose-dependent
inhibition.
Furthermore,
effective
antioxidant
activity
against
hydrogen
peroxide-induced
oxidative
stress
HEK-293
was
observed
for
prepared
electrospun
mats.
Journal of Surfactants and Detergents,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 10, 2024
Abstract
This
study
investigates
the
potential
synergy
effect
of
Ganoderma
lucidum
and
Lentinus
edodes
mushroom
extracts
delivered
through
niosomes
(composed
Span
40,
Tween
cholesterol)
for
anti‐cancer
antimicrobial
applications.
GC–MS
analysis
revealed
bioactive
compounds
such
as
d‐limonene,
ascorbic
acid,
ergosterol
in
extracts,
known
their
effects.
The
niosomal
formulations
exhibited
improved
physical
properties,
with
sizes
ranging
from
96
to
160
nm
polydispersity
index
(PDI)
values
range
0.29–0.54,
suggesting
that
had
an
acceptable
size
distribution
homogeneity.
In
cell
culture
studies,
demonstrated
significant
cytotoxic
effects
on
A549
lung
cancer
cells,
combination
both
leading
a
notable
decrease
viability
14.86%.
Additionally,
G.
L.
form
showed
varying
potent
properties
against
pathogenic
bacteria
(
Pseudomonas
aeruginosa
Staphylococcus
aureus
)
fungi
Candida
albicans
lower
minimum
inhibitory
concentration
(MIC)
compared
free
form,
indicating
synergistic
effect.
findings
highlight
combined
niosomes,
offering
valuable
insights
developing
novel
drug
delivery
systems.
Pathogens and Disease,
Год журнала:
2024,
Номер
82
Опубликована: Янв. 1, 2024
Abstract
Acinetobacter
baumannii
is
a
major
cause
of
nosocomial
infections
globally.
The
increasing
prevalence
multidrug-resistant
(MDR)
A.
has
become
an
important
public
health
concern.
To
combat
drug
resistance,
alternative
methods
such
as
phage
therapy
have
been
suggested.
In
total,
30
MDR
strains
were
isolated
from
clinical
specimens,
and
their
antibiotic
susceptibilities
determined.
vB_AbaS_SA1,
hospital
sewage,
was
characterized.
addition
to
its
plaque
size,
particle
morphology,
host
range,
genome
sequence
determined
annotated.
Finally,
the
antibacterial
effects
alone,
antibiotics
phage/antibiotic
combinations
assessed
against
strains.
Phage
vB_AbaS_SA1
had
siphovirus
showed
latent
period
20
min,
250
PFU/cell
(plaque
forming
unit/cell)
burst
size.
When
combined
with
antibiotics,
(SA1)
significant
phage-antibiotic
synergy
effect
reduced
overall
effective
concentration
in
time-kill
assessments.
SA1
linear
double-stranded
DNA
50
108
bp
size
guanine-cytosine
(GC)
content
39.15%.
Despite
potent
SA1,
it
necessary
perform
additional
research
completely
elucidate
mechanisms
action
potential
constraints
associated
utilizing
this
bacteriophage.
