Developing Lignin/Pva- Tea Tree Oil Composites for Enhanced Antibacterial and Antifungal Properties DOI

V. V. Adithyamol,

Payal Varma,

Balasubramanian Kandasubramanian

и другие.

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Окт. 31, 2024

This study investigates lignin-based bio-composites incorporated with polyvinyl alcohol (PVA) and varying concentrations of tea tree oil to assess their antibacterial antifungal properties. Lignin, a complex aromatic polymer an intricate three-dimensional network, is enriched conjugated systems oxygenated functional groups, including hydroxyl, methoxy, carbonyl groups. The novel exhibit significant antimicrobial activity, demonstrating potent efficacy against Escherichia coli Staphylococcus aureus as well notable Detailed characterization through FTIR SEM provides critical insights into the structural attributes composite films. results indicate that PVA-lignin films enhanced show superior resistance microbial proliferation. underscores potential these in applications such medical devices, packaging materials, environmental protection, addressing increasing demand for eco-friendly alternatives.

Язык: Английский

Synergistic effects of bacteriophage cocktail and antibiotics combinations against extensively drug-resistant Acinetobacter baumannii DOI Creative Commons
Sanaz Rastegar, Mikael Skurnik, Omid Tadjrobehkar

и другие.

BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)

Опубликована: Окт. 26, 2024

The extensively drug-resistant (XDR) strains of Acinetobacter baumannii have become a major cause nosocomial infections, increasing morbidity and mortality worldwide. Many different treatments, including phage therapy, are attractive ways to overcome the challenges antibiotic resistance. This study investigates biofilm formation ability 30 XDR A. isolates efficacy cocktail four tempetate bacteriophages (SA1, Eve, Ftm, Gln) antibiotics (ampicillin/sulbactam, meropenem, colistin) in inhibiting degrading biofilms these strains. majority (83.3%) exhibited strong formation. bacteriophage showed varying degrees effectiveness against biofilms, with higher concentrations generally leading more significant inhibition degradation rates. antibiotics-bacteriophage combinations also enhanced biofilms. findings suggested that is an effective tool combating its depending on concentration. Combining improved removal indicating promising strategy for managing infections. These results contribute our understanding dynamics potential cocktails as novel therapeutic approach combat antibiotic-resistant bacteria.

Язык: Английский

Процитировано

5

Enhancing Drug Delivery With Electrospun Biopolymer Nanofibers DOI

S. Shastri,

Payal Varma,

Balasubramanian Kandasubramanian

и другие.

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 23, 2024

Electrospinning stands out as a highly precise method for producing nanofibers, offering exceptional control over their morphology by adjusting parameters, making it the preferred choice efficiently tailoring nanofiber properties. Nanofibers, increasingly recognized possibilities within drug delivery systems that they possess, offer distinctive features such high surface area (10 to 1000m2/g), efficient loading, and ability provide sustained release. Fabricating nanofibers from biopolymers is particularly favored due numerous advantages including biocompatibility, capacity replicate extracellular matrix, biodegradability, non-cytotoxicity, renewability, them option other polymers various applications. In this regard, review thoroughly emphasizes drug-loaded electrospun diverse applications including, wound healing, pesticide release matrices, stent coatings, therapeutic It also discusses recent progress in incorporation into fabrication methods, assessment of loading release, kinetics. This provides insight about molecular interactions with help dynamics providing valuable insights can elucidate behavior molecules time, allowing researchers investigate dynamics, stability carriers, between drugs targets at level engineering next-generation systems.

Язык: Английский

Процитировано

4

Development, characterization, and evaluation of withaferin-A and artesunate-loaded pH-responsive acetal-dextran polymeric nanoparticles for the management of malaria DOI

Deepak Pradhan,

Prativa Biswasroy, Manish Ramchandani

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 273, С. 133220 - 133220

Опубликована: Июнь 17, 2024

Язык: Английский

Процитировано

3

Silymarin Functionalized Chitosan Nanoparticles as a Promising Theranostic Nanoplatform for Hepatocellular Carcinoma: Preparation, Characterization and In Vivo Biodistribution Assessment DOI
Mohamed Nasr,

Zienab E. Eldin,

Hend Fayez

и другие.

BioNanoScience, Год журнала: 2025, Номер 15(3)

Опубликована: Май 19, 2025

Язык: Английский

Процитировано

0

Silybin-Functionalized PCL Electrospun Fibrous Membranes for Potential Pharmaceutical and Biomedical Applications DOI Open Access
Christina Spartali, Anna‐Maria G. Psarra, Sotirios I. Marras

и другие.

Polymers, Год журнала: 2024, Номер 16(16), С. 2346 - 2346

Опубликована: Авг. 19, 2024

Silybin is a natural flavonolignan with potential anticancer, antioxidant, and hepatoprotective properties. In the present study, various loadings of silybin (1, 3, 5 wt%) were encapsulated in poly-ε-caprolactone (PCL) fibers by electrospinning, order to produce new pharmaceutical composites improved bioactive drug delivery The morphological characteristics composite fibrous structures evaluated scanning electron microscopy (SEM), encapsulation efficiency release rate quantified using UV-Vis spectrophotometer. analysis membranes’ thermal behavior differential calorimetry (DSC) thermogravimetric (TGA) revealed existence interaction between PCL silybin. An investigation cytocompatibility membranes that normal cells displayed an unimpeded proliferation respective concentrations; however, tumor cell growth demonstrated dose-dependent inhibition. Furthermore, effective antioxidant activity against hydrogen peroxide-induced oxidative stress HEK-293 was observed for prepared electrospun mats.

Язык: Английский

Процитировано

2

Nanoparticles for Cancer Gene Therapy and Imaging DOI

Donald A. Fernandes

Deleted Journal, Год журнала: 2024, Номер unknown

Опубликована: Окт. 21, 2024

Язык: Английский

Процитировано

2

Synergistic anti‐cancer and antimicrobial effects of Ganoderma lucidum and Lentinus edodes mushroom extracts‐loaded niosomes DOI

Saeed Zalnezhad,

Mahboubeh Adeli‐Sardou,

Maryam Roostaee

и другие.

Journal of Surfactants and Detergents, Год журнала: 2024, Номер unknown

Опубликована: Июль 10, 2024

Abstract This study investigates the potential synergy effect of Ganoderma lucidum and Lentinus edodes mushroom extracts delivered through niosomes (composed Span 40, Tween cholesterol) for anti‐cancer antimicrobial applications. GC–MS analysis revealed bioactive compounds such as d‐limonene, ascorbic acid, ergosterol in extracts, known their effects. The niosomal formulations exhibited improved physical properties, with sizes ranging from 96 to 160 nm polydispersity index (PDI) values range 0.29–0.54, suggesting that had an acceptable size distribution homogeneity. In cell culture studies, demonstrated significant cytotoxic effects on A549 lung cancer cells, combination both leading a notable decrease viability 14.86%. Additionally, G. L. form showed varying potent properties against pathogenic bacteria ( Pseudomonas aeruginosa Staphylococcus aureus ) fungi Candida albicans lower minimum inhibitory concentration (MIC) compared free form, indicating synergistic effect. findings highlight combined niosomes, offering valuable insights developing novel drug delivery systems.

Язык: Английский

Процитировано

1

Alginate-based bio-nanocomposite reinforced with poly(2-hydroxypropyl methacrylamide) and magnetite graphene oxide for delivery of etoposide and photothermal therapy DOI
Nuran Işıklan, Gülcan Geyik, Enes Güncüm

и другие.

Materials Today Chemistry, Год журнала: 2024, Номер 41, С. 102323 - 102323

Опубликована: Сен. 21, 2024

Язык: Английский

Процитировано

1

Characterization of bacteriophage vB_AbaS_SA1 and its synergistic effects with antibiotics against clinical multidrug-resistant Acinetobacter baumannii isolates DOI Creative Commons
Sanaz Rastegar, Salehe Sabouri, Omid Tadjrobehkar

и другие.

Pathogens and Disease, Год журнала: 2024, Номер 82

Опубликована: Янв. 1, 2024

Abstract Acinetobacter baumannii is a major cause of nosocomial infections globally. The increasing prevalence multidrug-resistant (MDR) A. has become an important public health concern. To combat drug resistance, alternative methods such as phage therapy have been suggested. In total, 30 MDR strains were isolated from clinical specimens, and their antibiotic susceptibilities determined. vB_AbaS_SA1, hospital sewage, was characterized. addition to its plaque size, particle morphology, host range, genome sequence determined annotated. Finally, the antibacterial effects alone, antibiotics phage/antibiotic combinations assessed against strains. Phage vB_AbaS_SA1 had siphovirus showed latent period 20 min, 250 PFU/cell (plaque forming unit/cell) burst size. When combined with antibiotics, (SA1) significant phage-antibiotic synergy effect reduced overall effective concentration in time-kill assessments. SA1 linear double-stranded DNA 50 108 bp size guanine-cytosine (GC) content 39.15%. Despite potent SA1, it necessary perform additional research completely elucidate mechanisms action potential constraints associated utilizing this bacteriophage.

Язык: Английский

Процитировано

1

Graphene oxide nanoribbons conjugated with 1, 2-distearoyl-sn-glycero-3 phosphoethanolamine-poly (ethylene glycol)-transferrin enhanced targeted delivery and cytotoxicity of raloxifene against breast cancer DOI
Asha P. Johnson,

S.L. Jyothi,

Muhammad Shahid

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 278, С. 134772 - 134772

Опубликована: Авг. 16, 2024

Язык: Английский

Процитировано

0