Molecular Mechanism of Phytochemical Compounds in Mitigating Hypertension DOI Creative Commons
Putri Cahaya Situmorang, Syahputra Wibowo,

Masitta Tanjung

и другие.

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100812 - 100812

Опубликована: Май 1, 2025

Язык: Английский

Puerarin reduces susceptibility to ventricular arrhythmias and inhibits ferroptosis via Sirt1/Nrf2 signaling in high-fat-diet rats DOI
Shuang Jiang,

Suhua Qiu,

Yu Mu

и другие.

Free Radical Biology and Medicine, Год журнала: 2024, Номер unknown

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

3
Protective effect of puerarin in diabetic nephropathy: A systematic review and meta-analysis of animal studies DOI
Xiaoying Xu, Shiyu Shen,

Yingying Dong

и другие.

Phytomedicine, Год журнала: 2025, Номер 138, С. 156385 - 156385

Опубликована: Янв. 11, 2025

Язык: Английский

Процитировано

0
Efficacy and safety of puerarin injection as an adjunctive therapy for chronic heart failure: a systematic review and meta-analysis DOI Creative Commons

Hesong Fan,

Jingrong Yang,

Huaizhe Wang

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Апрель 28, 2025

Puerarin injection is used for the treatment of chronic heart failure (CHF). The objective this study to investigate efficacy and safety puerarin as an adjunct therapy CHF through a meta-analysis systematic review. We conducted comprehensive literature search across eight databases, including PubMed, Embase, Web Science, Cochrane Library, up 1 March 2025, identify required randomized controlled trials (RCTs). Subsequently, we assessed included studies according principles outlined in Handbook performed using RevMan 5.4 Stata 12.0. A total 29 RCTs were included, comprising 2,480 patients, with 1,251 group 1,229 control group. demonstrated that combined conventional medication significantly improved cardiac function parameters patients compared pharmacotherapy alone, left ventricular ejection fraction (MD = 6.22, 95% CI [3.11, 9.33], P < 0.01), output 0.45, [0.35, 0.55], stroke volume 3.29, [2.02, 4.57], while reducing end-diastolic diameter -0.83, [-1.24, -0.42], 0.01). combination both increased effectiveness rate (RR 1.26, [1.21, 1.31], 0.01) hemodynamic parameters, along favorable modulation oxidative stress markers evidenced by elevated superoxide dismutase, glutathione peroxidase, catalase levels concomitant reduced lipid peroxidation malondialdehyde concentrations. This suggests adjunctive may provide benefits management, clinical outcomes, enhanced function, attenuated remodeling, optimized performance, stress, maintaining profile comparable therapy. However, due suboptimal quality some degree heterogeneity existing evidence, there need more high-quality reliable evidence its future application. https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022371583.

Язык: Английский

Процитировано

0
Molecular Mechanism of Phytochemical Compounds in Mitigating Hypertension DOI Creative Commons
Putri Cahaya Situmorang, Syahputra Wibowo,

Masitta Tanjung

и другие.

Phytomedicine Plus, Год журнала: 2025, Номер unknown, С. 100812 - 100812

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0