Animals, Год журнала: 2024, Номер 14(22), С. 3165 - 3165
Опубликована: Ноя. 5, 2024
Sleep deprivation (SD) disrupts circadian rhythms; however, its effects on SD and the mechanisms involved require further investigation. Previous studies were mainly conducted rodents, such as mice, with few liver of large diurnal animals, sheep. In this study, we used a Tibetan sheep model for first time to investigate by exposing (
Язык: Английский
Tissue and Cell, Год журнала: 2025, Номер 95, С. 102848 - 102848
Опубликована: Март 8, 2025
Язык: Английский
Процитировано
1
Phytotherapy Research, Год журнала: 2024, Номер 38(11), С. 5107 - 5133
Опубликована: Авг. 15, 2024
Abstract Central nervous system (CNS)‐related diseases have a high mortality rate, are serious threat to physical and mental health, always been an important area of research. Gastrodin, the main active metabolite Gastrodia elata Blume, used in Chinese medicine food, has wide range pharmacological effects, mostly related CNS disorders. This review aims systematically summarize discuss effects underlying mechanisms gastrodin treatment diseases, assess its potential for further development as lead drug both biomedicine traditional medicine. Studies on indicate that it may exert anti‐neurodegenerative, cerebrovascular protective, ameliorative diabetic encephalopathy, perioperative neurocognitive dysfunction, epilepsy, Tourette's syndrome, depression anxiety, sleep disorders through various mechanisms. To date, 110 products approved clinical use, but multicenter case–control studies relatively scarce. Preclinical confirmed can be treat CNS‐related However, concerns need addressed context likely non‐specific, assay interfering when is studied using vitro silico approaches, calling systematic assessment evidence date. High‐quality trials should priority evaluate therapeutic safety efficacy gastrodin. Further experimental research appropriate vivo models also needed, focusing neurodegenerative cerebral ischemic hypoxic brain damage caused by methamphetamine or heavy metals, epilepsy.
Язык: Английский
Процитировано
5
Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown
Опубликована: Май 6, 2025
Язык: Английский
Процитировано
0
The American Journal of Chinese Medicine, Год журнала: 2025, Номер 53(03), С. 803 - 831
Опубликована: Янв. 1, 2025
Gastrodia elata Blume, a traditional medicinal herb primarily used in Asian countries such as China, has long been valued for treating headaches, dizziness, spasms, epilepsy, strokes, forgetfulness, and other ailments. Gastrodin, glycoside analog major bioactive component of garnered significant scientific attention owing to its extensive pharmacological effects. It is commonly obtained through plant extraction, chemical synthesis, biosynthesis. Gastrodin exhibits remarkable modulatory effects on the central nervous system (CNS), with promising applications neurodegenerative diseases Parkinson’s disease (PD) Alzheimer’s (AD), affective cognitive disorders. Furthermore, pharmacokinetics (PK) gastrodin extensively reviewed. As small molecule drug, this study focused efficiency molecular mechanisms CNS disorders, aiming elucidate interactions targets. This provides valuable insights development addresses drawbacks unclear Chinese medicine.
Язык: Английский
Процитировано
0
Brain Research Bulletin, Год журнала: 2025, Номер unknown, С. 111412 - 111412
Опубликована: Май 1, 2025
Sleep is an important physiological process to maintain health, which involves the regulation of many systems in body, not only closely related hormone balance, immune system and nervous function body. Recent studies have emphasized complex relationship between sleep cell death mechanisms. Ferroptosis a form iron-dependent death, variety neurodegenerative diseases. plays role regulating brain metabolism, overall intracellular homeostasis. New evidence suggests that there two-way interaction ferroptosis. interruption may enhance ferroptosis pathway, turn change quality sleep. Understanding this essential reveal underlying mechanisms neurodegeneration develop potential therapeutic interventions. This review combines results current on molecular cellular extensive health. Special attention paid effects deprivation iron metabolism oxidative stress, play The also explores homeostasis how disorders promote accumulation brain, accelerate disorders, especially chronic deprivation, create favorable environment for by affecting stress levels brain. Conversely, associated with siderosis disrupts normal patterns, forming circulatory exacerbates will provide valuable insights into aging age-related In addition, pathways involved can new methods prevention treatment diseases other ferroptosis-related pathology.
Язык: Английский
Процитировано
0
Scientia Horticulturae, Год журнала: 2024, Номер 337, С. 113595 - 113595
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
1
Biology, Год журнала: 2024, Номер 13(9), С. 730 - 730
Опубликована: Сен. 17, 2024
, commonly known as Tian Ma, is a perennial mycoheterotrophic orchid. Qianyang Ma (QTM), geographical indication agricultural product from Hongjiang City, Hunan Province, China, primarily characterized by the red variety,
Язык: Английский
Процитировано
1
Animals, Год журнала: 2024, Номер 14(22), С. 3165 - 3165
Опубликована: Ноя. 5, 2024
Sleep deprivation (SD) disrupts circadian rhythms; however, its effects on SD and the mechanisms involved require further investigation. Previous studies were mainly conducted rodents, such as mice, with few liver of large diurnal animals, sheep. In this study, we used a Tibetan sheep model for first time to investigate by exposing (
Язык: Английский
Процитировано
0