AdipoRon’s Impact on Alzheimer’s Disease—A Systematic Review and Meta-Analysis

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 484 - 484

Опубликована: Янв. 8, 2025

Alzheimer's disease (AD) remains a leading cause of cognitive decline and mortality worldwide, characterized by neurodegeneration, synaptic deficiencies, neuroinflammation. Despite advancements in early detection, diagnosis, treatment, AD presents substantial challenges due to its complex pathology, heterogeneity, the limited efficacy current therapies. Consequently, there is pressing need for novel therapeutic agents target multifaceted aspects enhance treatments, minimize adverse effects. AdipoRon, an adiponectin receptor agonist, has garnered interest potential neuroprotective effects, including reducing neuroinflammation, improving mitochondrial function, mitigating tau hyperphosphorylation. This review aimed evaluate effects AdipoRon-based replacement therapy against AD, using comprehensive approach grounded PICO framework-Population, Intervention, Comparison, Outcomes. A total six studies were reviewed, vitro vivo investigations examining AdipoRon's impact on various models. These involved different cell lines transgenic mouse models, assessing outcomes such as phosphorylation, relevant molecular pathways. By synthesizing data from these studies, our thoroughly explains mechanisms action, agent AD. analysis aims highlight state knowledge, identify gaps research, suggest directions future clinical applications.

Язык: Английский

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Adipokines in the Crosstalk between Adipose Tissues and Other Organs: Implications in Cardiometabolic Diseases

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2129 - 2129

Опубликована: Сен. 19, 2024

Adipose tissue was previously regarded as a dormant organ for lipid storage until the identification of adiponectin and leptin in early 1990s. This revelation unveiled dynamic endocrine function adipose tissue, which has expanded further. emerged recent decades multifunctional that plays significant role energy metabolism homeostasis. Currently, it is evident primarily performs its by secreting diverse array signaling molecules known adipokines. Apart from their pivotal expenditure regulation, these adipokines exert influence over multitude biological processes, including but not limited to inflammation, thermoregulation, immune response, vascular function, insulin sensitivity. Adipokines are regulating numerous processes within facilitating communication between various organs, brain, gut, pancreas, endothelial cells, liver, muscle, more. Dysregulated have been implicated several metabolic diseases, like obesity diabetes, well cardiovascular diseases. In this article, we attempted describe significance developing diseases highlight crosstalk tissues other organs.

Язык: Английский

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Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions

Biomedicines, Год журнала: 2024, Номер 12(9), С. 2096 - 2096

Опубликована: Сен. 13, 2024

The triad of vascular impairment, muscle atrophy, and cognitive decline represents critical age-related conditions that significantly impact health. Vascular impairment disrupts blood flow, precipitating the mass reduction seen in sarcopenia neuronal function characteristic neurodegeneration. Our limited understanding intricate relationships within this hinders accurate diagnosis effective treatment strategies. This review analyzes interrelated mechanisms contribute to these conditions, with a specific focus on oxidative stress, chronic inflammation, impaired nutrient delivery. aim is understand common pathways involved suggest comprehensive therapeutic approaches. dysfunctions hinder circulation transportation nutrients, resulting characterized by atrophy weakness. dysfunction have negative physical quality life. Neurodegenerative diseases exhibit comparable pathophysiological affect motor functions. Preventive approaches encompass lifestyle adjustments, addressing integrated therapies improving muscular well-being. Better links can refine strategies yield better patient outcomes. study emphasizes complex interplay between dysfunction, degeneration, decline, highlighting necessity for multidisciplinary Advances domain promise improved diagnostic accuracy, more options, enhanced preventive measures, all contributing higher life elderly population.

Язык: Английский

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Mechanisms and effects of AdipoRon, an adiponectin receptor agonist, on ovarian granulosa cells—a systematic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

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