Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment DOI Creative Commons
Keiko Iwata, Masafumi Noguchi, Norihito Shintani

и другие.

Biomolecules, Год журнала: 2025, Номер 15(2), С. 184 - 184

Опубликована: Янв. 27, 2025

Mitochondria are essential for brain function, and accumulating evidence from postmortem studies, neuroimaging, basic research indicates mitochondrial impairments in patients with psychiatric disorders. Restoring function therefore represents a promising therapeutic strategy these conditions. Mitochondrial transplantation, an innovative approach that uses functional mitochondria to repair damaged cells, has demonstrated efficacy through various delivery methods cell, animal, animal disease models. This review explores the critical link between disorders provides overview of transplantation as intervention. It highlights recent advances models disorders, focusing on methods, timing administration, integration exogenous into cells. The potential effects mechanisms underlie discussed. Additionally, this evaluates clinical relevance, challenges, future strategies application treatment

Язык: Английский

Mitochondrial Transplantation in Animal Models of Psychiatric Disorders: A Novel Approach to Psychiatric Treatment DOI Creative Commons
Keiko Iwata, Masafumi Noguchi, Norihito Shintani

и другие.

Biomolecules, Год журнала: 2025, Номер 15(2), С. 184 - 184

Опубликована: Янв. 27, 2025

Mitochondria are essential for brain function, and accumulating evidence from postmortem studies, neuroimaging, basic research indicates mitochondrial impairments in patients with psychiatric disorders. Restoring function therefore represents a promising therapeutic strategy these conditions. Mitochondrial transplantation, an innovative approach that uses functional mitochondria to repair damaged cells, has demonstrated efficacy through various delivery methods cell, animal, animal disease models. This review explores the critical link between disorders provides overview of transplantation as intervention. It highlights recent advances models disorders, focusing on methods, timing administration, integration exogenous into cells. The potential effects mechanisms underlie discussed. Additionally, this evaluates clinical relevance, challenges, future strategies application treatment

Язык: Английский

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