Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV DOI Creative Commons

Zhongsong Zhang,

Ru Yu Tan, Zhengang Xiong

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 12, 2025

Photoaging, the premature aging of skin due to chronic ultraviolet (UV) exposure, is a growing concern in dermatology and cosmetic science. While UV radiation known induce DNA damage, oxidative stress, inflammation cells, recent research unveils promising countermeasure: autophagy. This review explores intricate relationship between autophagy photoaging, highlighting how this cellular recycling process can mitigate UV-induced damage. We begin by examining differential impacts UVA UVB on cells role stress accelerating photoaging. Next, we delve into molecular mechanisms autophagy, including its various forms regulatory pathways. Central discussion autophagy's protective functions, such as clearance damaged organelles proteins, maintaining genomic integrity. Furthermore, address current challenges harnessing for therapeutic purposes, need selective inducers deeper understanding context-dependent effects. By synthesizing advancements proposing future directions, underscores potential modulation novel strategy prevent treat comprehensive analysis aims inspire further investigation autophagy-based interventions, offering new hope preserving health face environmental stressors.

Язык: Английский

Dysregulation of autophagy during photoaging reduce oxidative stress and inflammatory damage caused by UV DOI Creative Commons

Zhongsong Zhang,

Ru Yu Tan, Zhengang Xiong

и другие.

Frontiers in Pharmacology, Год журнала: 2025, Номер 16

Опубликована: Май 12, 2025

Photoaging, the premature aging of skin due to chronic ultraviolet (UV) exposure, is a growing concern in dermatology and cosmetic science. While UV radiation known induce DNA damage, oxidative stress, inflammation cells, recent research unveils promising countermeasure: autophagy. This review explores intricate relationship between autophagy photoaging, highlighting how this cellular recycling process can mitigate UV-induced damage. We begin by examining differential impacts UVA UVB on cells role stress accelerating photoaging. Next, we delve into molecular mechanisms autophagy, including its various forms regulatory pathways. Central discussion autophagy's protective functions, such as clearance damaged organelles proteins, maintaining genomic integrity. Furthermore, address current challenges harnessing for therapeutic purposes, need selective inducers deeper understanding context-dependent effects. By synthesizing advancements proposing future directions, underscores potential modulation novel strategy prevent treat comprehensive analysis aims inspire further investigation autophagy-based interventions, offering new hope preserving health face environmental stressors.

Язык: Английский

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