The Ameliorative Effects of Probiotics on the Sperm Quality and Testicular Structure After Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion DOI Creative Commons
Zohresadat Akbari, Narges Karbalaei, Saied Karbalay‐Doust

и другие.

Andrologia, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Oxidative stress is a critical contributor to the pathophysiology of ischemia/reperfusion (I/R) injury associated with testicular torsion (TT) and detorsion (D) (TT/D). This study examines antioxidative properties probiotics Lactobacillus (L.) reuteri rhamnosus in ameliorating TT/D‐induced oxidative histological damage. Male Sprague–Dawley rats ( n = 6 per group) were allocated into five experimental groups: sham‐operated group, torsion/detorsion (T/D) three T/D groups treated L. (T/D+LRe), (T/D+LRm), or combination both (T/D+LRe+LRm). TT was induced by rotating right testis 720° clockwise for 2 h, followed 60 days reperfusion. The then excised further analysis. evaluated parameters included sperm quality, hormone levels (FSH, LH, testosterone), as well malondialdehyde (MDA) glutathione (GSH). Additionally, activities myeloperoxidase (MPO) catalase (CAT), peroxidase (GPx), superoxide dismutase (SOD), changes, assessed. findings demonstrated that TT/D significantly increased FSH LH levels, reduced quality testosterone elevated MDA enhanced MPO activity. GSH GPx, CAT, SOD. Probiotic treatment, particularly , antioxidant enzymes GPx CAT while reducing Histopathological analysis revealed severe damage, including reductions spermatogenic, sertoli, Leydig cells following TT/D, mitigated . These results suggest probiotics, especially may protect against I/R rat model T/D, likely due their properties.

Язык: Английский

Effect of geraniol on cyclooxygenase-2 and inducible nitric oxide synthase levels in a rat hepatic ischemia/reperfusion model DOI
Sara Shafieipour,

Hamid Khajehpour,

Shahriar Dabiri

и другие.

Nutrire, Год журнала: 2025, Номер 50(1)

Опубликована: Март 31, 2025

Язык: Английский

Процитировано

0
The Ameliorative Effects of Probiotics on the Sperm Quality and Testicular Structure After Ischemia/Reperfusion Injury Following Testicular Torsion/Detorsion DOI Creative Commons
Zohresadat Akbari, Narges Karbalaei, Saied Karbalay‐Doust

и другие.

Andrologia, Год журнала: 2025, Номер 2025(1)

Опубликована: Янв. 1, 2025

Oxidative stress is a critical contributor to the pathophysiology of ischemia/reperfusion (I/R) injury associated with testicular torsion (TT) and detorsion (D) (TT/D). This study examines antioxidative properties probiotics Lactobacillus (L.) reuteri rhamnosus in ameliorating TT/D‐induced oxidative histological damage. Male Sprague–Dawley rats ( n = 6 per group) were allocated into five experimental groups: sham‐operated group, torsion/detorsion (T/D) three T/D groups treated L. (T/D+LRe), (T/D+LRm), or combination both (T/D+LRe+LRm). TT was induced by rotating right testis 720° clockwise for 2 h, followed 60 days reperfusion. The then excised further analysis. evaluated parameters included sperm quality, hormone levels (FSH, LH, testosterone), as well malondialdehyde (MDA) glutathione (GSH). Additionally, activities myeloperoxidase (MPO) catalase (CAT), peroxidase (GPx), superoxide dismutase (SOD), changes, assessed. findings demonstrated that TT/D significantly increased FSH LH levels, reduced quality testosterone elevated MDA enhanced MPO activity. GSH GPx, CAT, SOD. Probiotic treatment, particularly , antioxidant enzymes GPx CAT while reducing Histopathological analysis revealed severe damage, including reductions spermatogenic, sertoli, Leydig cells following TT/D, mitigated . These results suggest probiotics, especially may protect against I/R rat model T/D, likely due their properties.

Язык: Английский

Процитировано

0