Natural Product Communications, Год журнала: 2025, Номер 20(5)

Опубликована: Май 1, 2025

Objectives: Geraniol, a natural compound found in various essential oils and plant extracts, has shown promising anti-cancer effects on multiple types of cancer. This study aimed to examine the properties hyaluronic acid (HA)-conjugated geraniol (HA-geraniol) specifically breast cancer cells. Methods: investigated HA-geraniol both murine 4T1 human MDA-MB-231 cell lines. Mitochondrial membrane potential loss, apoptosis-inducing ability, cycle arrest were evaluated using flow cytometry. Additionally, tandem mass tag (TMT)-based proteomics analysis was conducted identify differentially expressed proteins cells following treatment with HA-geraniol. An vivo efficacy carried out 4T1-bearing BALB/c mouse xenograft model assess therapeutic impact compared naked drug. Results: The vitro experiments demonstrated that exhibited superior It induce mitochondrial apoptosis, Proteomic revealed may mediate death by up-regulating ATF3 activating complement coagulation cascade pathways. Furthermore, indicated effectively suppressed tumor growth metastasis model, showcasing its as agent for therapy. Conclusion: findings from this suggest holds great promise an efficient therapy, demonstrating significant .

Язык: Английский