Handbook of Religion and Health

Oxford University Press eBooks, Год журнала: 2023, Номер unknown

Опубликована: Ноя. 23, 2023

Abstract The 2001 (first) edition of this Handbook was a comprehensive review history, research, and discussions on religion health through the year 2000. Appendix listed 1,200 separate quantitative studies each rated in quality 0–10 scale, followed by about 2,000 references an extensive index for rapid topic identification. 2012 (second) systematically updated research from 2000 to 2010, with number then reaching thousands. This 2023 (third) is most scientifically rigorous date, covering best published 2021 emphasis prospective randomized controlled trials. Beginning Foreword Dr. Howard K. Koh, former US Assistant Secretary Health Department Human Services, nearly 600,000-word volume examines almost every aspect health, reviewing past more recent relationship between outcomes. Furthermore, all its 34 chapters conclude clinical community applications, making text relevant both healthcare professionals (physicians, nurses, social workers, rehabilitation therapists, counselors, psychologists, sociologists, etc.) clergy (community clergy, chaplains, pastoral etc.). book’s focuses studies, describing study single line, allowing researchers quickly locate existing research. It should not be surprising that two decades has been cited health.

Язык: Английский

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Advances in the science and treatment of alcohol use disorder

Science Advances, Год журнала: 2019, Номер 5(9)

Опубликована: Сен. 6, 2019

Pharmacological and behavioral treatments exist for alcohol use disorder, but more are needed, several under development.

Язык: Английский

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Sex differences in stress-related alcohol use

Neurobiology of Stress, Год журнала: 2019, Номер 10, С. 100149 - 100149

Опубликована: Фев. 1, 2019

Rates of alcohol use disorder (AUD) have increased in women by 84% over the past ten years relative to a 35% increase men. This substantive female drinking is alarming given that experience greater alcohol-related health consequences compared Stress strongly associated with all phases addiction, including initiation, maintenance, and relapse for both men, but plays an especially critical role women. The purpose present narrative review highlight what known about sex differences relationship between stress drinking. reactivity negative affect play initiating maintaining addressed, available evidence reinforcement as it relates brain systems presented. discusses structures neurotransmitters may underlie stress-related (e.g., prefrontal cortex, amygdala, norepinephrine, corticotropin releasing factor, dynorphin), involvement alcohol-induced neurodegeneration, ovarian hormones Finally, potential avenues development sex-appropriate pharmacological behavioral treatments AUD are identified. Overall, generally more likely drink regulate reactivity. Sex onset maintenance begin develop during adolescence, coinciding exposure early life stress. These factors continue into adulthood, when reduced responsivity stress, affect-related psychiatric comorbidities neurodegeneration contribute chronic problematic use, particularly However, current research limited regarding examination initiation use. Probing regions important future direction developing address AUD.

Язык: Английский

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Novel Agents for the Pharmacological Treatment of Alcohol Use Disorder

Drugs, Год журнала: 2022, Номер 82(3), С. 251 - 274

Опубликована: Фев. 1, 2022

Alcohol use disorder (AUD) is a highly prevalent but severely under-treated disorder, with only three widely-approved pharmacotherapies. Given that AUD very heterogeneous it unlikely one single medication will be effective for all individuals an AUD. As such, there need to develop new, more effective, and diverse pharmacological treatment options the hopes of increasing utilization improving care. In this qualitative literature review, we discuss efficacy, mechanism action, tolerability approved, repurposed, novel pharmacotherapies clinical perspective. Pharmacotherapies discussed include: disulfiram, acamprosate, naltrexone, nalmefene, topiramate, gabapentin, varenicline, baclofen, sodium oxybate, aripiprazole, ondansetron, mifepristone, ibudilast, suvorexant, prazosin, doxazosin, N-acetylcysteine, GET73, ASP8062, ABT-436, PF-5190457, cannabidiol. Overall, many repurposed agents in review demonstrate effectiveness promise future treatment. Importantly, these medications also offer potential improvements towards advancement precision medicine personalized population. However, remains great improve access treatment, increase menu approved treatments, de-stigmatize treatment-seeking

Язык: Английский

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Co-Occurring Alcohol Use Disorder and Anxiety: Bridging the Psychiatric, Psychological, and Neurobiological Perspectives

Alcohol research, Год журнала: 2019, Номер 40(1)

Опубликована: Янв. 1, 2019

A substantial number of people who have problems with alcohol also experience strong anxiety and mood problems.This article provides an overview the evolving perspectives this association in context three related disciplines-psychiatry, psychology, neuroscience.Psychiatric epidemiological studies show that having either anxiety-or alcohol-related diagnosis elevates prospective risk for developing other disorder.From psychological perspective, behavioral research demonstrates drinking to cope negative affect is a potent marker current future alcohol.Neuroscientific implicates overlapping neurobiological systems processes promoting rise misuse.The psychiatric perspective misuse co-occurring represent neurobiologically distinct diagnostic conditions has dominated field many decades.However, recent increasing support neuroscientific these share underlying, mutually exacerbating, processes.

Язык: Английский

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Noradrenergic targets for the treatment of alcohol use disorder

Psychopharmacology, Год журнала: 2018, Номер 235(6), С. 1625 - 1634

Опубликована: Фев. 20, 2018

Язык: Английский

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Evaluating the Impact of Concurrent Sucrose Availability on Operant Ethanol Self-Administration in Male and Female Long Evans Rats

Addiction Neuroscience, Год журнала: 2025, Номер 14, С. 100196 - 100196

Опубликована: Янв. 18, 2025

Язык: Английский

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The Amygdala Noradrenergic System Is Compromised With Alcohol Use Disorder

Biological Psychiatry, Год журнала: 2022, Номер 91(12), С. 1008 - 1018

Опубликована: Апрель 13, 2022

Язык: Английский

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New insights into the molecular basis of alcohol abstinence and relapse in alcohol-associated liver disease

Hepatology, Год журнала: 2023, Номер unknown

Опубликована: Окт. 20, 2023

Alcohol use disorder remains a significant public health concern, affecting around 5% of adults worldwide. Novel pathways damage have been described during the last years, providing insight into mechanism injury due to alcohol misuse beyond direct effect ethanol byproducts on liver parenchyma and neurobehavioral mechanisms. Thus, gut-liver-brain axis immune system involvement could be therapeutic targets for disorder. In particular, changes in gut microbiota composition function, bile acid homeostasis, shown with consumption cessation. can also directly disrupt intestinal blood-brain barriers. Activation triggered by barrier dysfunction translocation bacteria, pathogen-associated molecular patterns (such as lipopolysaccharide), cytokines, damage-associated patterns. These factors, turn, promote brain inflammation progression fibrosis. Other involved mechanisms include oxidative stress, apoptosis, autophagy, release extracellular vesicles miRNA from hepatocytes. Potential (probiotics fecal transplantation), neuroinflammatory pathways, well neuroendocrine example, ghrelin (ghrelin receptor blockade), incretin mimetics (glucagon-like peptide-1 analogs), mineralocorticoid (spironolactone). addition, support psychological behavioral treatments is essential address multiple dimensions future, personalized approach considering these novel contribute significantly decreasing alcohol-associated burden disease.

Язык: Английский

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Understanding the neurobiological effects of drug abuse: Lessons from zebrafish models

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Год журнала: 2020, Номер 100, С. 109873 - 109873

Опубликована: Янв. 22, 2020

Drug abuse and brain disorders related to drug comsumption are public health problems with harmful individual social consequences. The identification of therapeutic targets precise pharmacological treatments these neuropsychiatric conditions associated urgently needed. Understanding the link between neurobiological mechanisms behavior is a key aspect elucidating abuse-related targets. Due various molecular, biochemical, pharmacological, physiological features, zebrafish (Danio rerio) has been considered suitable vertebrate for modeling complex processes involved in responses. In this review, we discuss how successfully used neurobehavioral phenotypes review effects opioids, cannabinoids, alcohol, nicotine, psychedelic drugs on central nervous system (CNS). Moreover, summarize recent advances zebrafish-based studies outline potential advantages limitations existing models explore neurochemical bases addiction. Finally, use may present fruitful approaches provide valuable clinically translatable data.

Язык: Английский

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