The Gut–Heart Axis: Molecular Perspectives and Implications for Myocardial Infarction
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12465 - 12465
Опубликована: Ноя. 20, 2024
Myocardial
infarction
(MI)
remains
the
leading
cause
of
death
globally,
imposing
a
significant
burden
on
healthcare
systems
and
patients.
The
gut-heart
axis,
bidirectional
network
connecting
gut
health
to
cardiovascular
outcomes,
has
recently
emerged
as
critical
factor
in
MI
pathophysiology.
Disruptions
this
including
dysbiosis
compromised
intestinal
barrier
integrity,
lead
systemic
inflammation
driven
by
gut-derived
metabolites
like
lipopolysaccharides
(LPSs)
trimethylamine
N-oxide
(TMAO),
both
which
exacerbate
progression.
In
contrast,
such
short-chain
fatty
acids
(SCFAs)
from
balanced
microbiota
exhibit
protective
effects
against
cardiac
damage.
This
review
examines
molecular
mediators
considering
role
factors
sex-specific
hormones,
aging,
diet,
physical
activity,
alcohol
consumption
outcomes.
Additionally,
we
highlight
therapeutic
approaches,
dietary
interventions,
personalized
probiotics,
exercise
regimens.
Addressing
axis
holds
promise
for
reducing
risk
improving
recovery,
positioning
it
novel
target
therapy.
Язык: Английский
Sotagliflozin attenuates cardiac dysfunction and depression-like behaviors in mice with myocardial infarction through the gut-heart-brain axis
Neurobiology of Disease,
Год журнала:
2024,
Номер
199, С. 106598 - 106598
Опубликована: Июль 11, 2024
Myocardial
infarction
(MI)
and
depression
are
leading
causes
of
mortality
morbidity
globally,
these
conditions
increasing
recognized
as
being
fundamentally
interconnected.
The
recently
gut-heart-brain
axis
offers
insights
into
following
MI,
but
effective
treatments
for
this
comorbidity
remain
lacking.
To
address
medical
need,
we
employed
an
animal
model
MI
to
investigate
the
potential
repurposing
sotagliflozin
(SOTA),
approved
sodium-glucose
cotransporter
1
2
(SGLT1/2)
inhibitor
diabetes,
managing
identifying
SOTA-associated
microbial
mechanisms.
SOTA
treatment
improved
cardiac
dysfunction
alleviated
depression-like
behaviors
induced
by
accompanied
alterations
in
gut
microbiota
composition,
such
changes
Prevotellaceae
NK3B31
group,
Alloprevotella,
UCG-001.
Moreover,
fecal
transplantation
(FMT)
using
samples
from
SOTA-treated
mice
demonstrated
that
contributed
beneficial
effects
on
mice.
Intriguingly,
FMT-based
intervention
concordance
analysis
before
after
FMT
suggested
UCG-001
were
associated
with
SOTA.
Furthermore,
functional
prediction
correlation
support
significance
dynamic
communities.
In
conclusion,
findings
suggest
could
serve
a
drug
ameliorate
depressive
symptoms
patients
via
through
axis.
Язык: Английский
Progress on the mechanism of intestinal microbiota against colorectal cancer
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 28, 2025
The
intestinal
microbiota
plays
a
crucial
role
in
the
occurrence
and
development
of
colorectal
cancer,
its
anti
-
cancer
mechanism
has
become
research
hotspot.
This
article
comprehensively
expounds
on
molecular
mechanisms
including
aspects
such
as
immune
regulation,
activation
carcinogenic
signaling
pathways
(it
should
be
noted
that
it
is
more
reasonable
to
"inhibition
pathways"),
metabolite
mediated
effects,
maintenance
barrier
function.
At
same
time,
explores
roles
potential
intervention
methods
probiotic
supplementation
therapy,
immunotherapy,
fecal
transplantation.
In
addition,
analyzes
impact
flora
therapeutic
efficacy
cancer.
existing
results
are
summarized,
future
directions
prospected,
with
aim
providing
new
theoretical
bases
treatment
ideas
for
prevention
Язык: Английский