The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats

Behavioural Brain Research, Год журнала: 2024, Номер 468, С. 115039 - 115039

Опубликована: Май 6, 2024

Язык: Английский

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BDNF and GSK-3beta expression changes underlie the beneficial effects of crocin on behavioral alterations in a rat model of autism induced by prenatal valproic acid administration

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 8, 2025

Язык: Английский

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Brain-derived neurotrophic factor (BDNF) changes in rodent models of schizophrenia induced by ketamine: a systematic review

Naunyn-Schmiedeberg s Archives of Pharmacology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 20, 2025

Язык: Английский

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Exploring Crocin’s Role in Alleviating Memory Impairments and Depression-like Behaviors Induced by REM Sleep Deprivation, Focusing on BDNF and GSK-3β in Male Rats

Molecular Neurobiology, Год журнала: 2025, Номер unknown

Опубликована: Март 3, 2025

Язык: Английский

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Crocin facilitates the effect of fear extinction on freezing behavior and BDNF level in a rat model of fear-conditioning

Learning and Motivation, Год журнала: 2025, Номер 89, С. 102095 - 102095

Опубликована: Янв. 11, 2025

Язык: Английский

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Construction and validation of a predictive model for sleep disorders among pregnant women

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Март 6, 2025

Sleep disorders are among the most common major problems during pregnancy. Most studies on sleep of pregnant women closely related to adverse birth outcomes. In this study, our aim was develop and validate a predictive model for risk in women. A total 2,467 healthy were enrolled randomly partitioned into training set validation at ratio 7:3. During variable selection stage, Pearson's chi-square test employed identify variables with p-value below 0.05, which then designated as candidate subsequent logistic regression analysis. Concurrently, LASSO technique utilized sift through isolate valuable variables. Ultimately, we developed binary Logistic models predicated (Model 1) 2). The performance nomograms evaluated using Bootstrap resampling procedure, sensitivity specificity receiver-operating characteristic (ROC), area under ROC curve (AUC), decision analysis (DCA). 439 (25.4%) 208 (28.1%) exhibited disorder, respectively. prediction shared 6 factors (age, anxiety, depression, family functions, degree pregnancy reaction, pre-pregnancy physical condition). Model 1, 69.4%, 59.6%. When weeks, residence, only child included 2, 82.4% 54.8%. set, areas 1 2 0.678 (0.635, 0.720), 0.719 (0.678, 0.761), showed that calibration is approximately distributed along reference line. Decision analyses demonstrated favorable net benefit within range threshold probability nomograms. superior performance, can serve convenient reliable tool predicting

Язык: Английский

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Different protocols of REM sleep deprivation led to controversial effects on OCD- and anxiety-like behaviors and locomotor activity in fear conditioning male and female rats with respect to BDNF expression level

Pharmacology Biochemistry and Behavior, Год журнала: 2025, Номер 252, С. 174027 - 174027

Опубликована: Апрель 30, 2025

Язык: Английский

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Exploring Dapagliflozin’s Influence on Autophagic Flux in Mania-like Behaviour: Insights from the LKB1/AMPK/LC3 Pathway in a Mouse Model

Journal of Neuroimmune Pharmacology, Год журнала: 2025, Номер 20(1)

Опубликована: Май 22, 2025

Язык: Английский

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Molecular Effects of Cornelian Cherry Fruit (Cornus mas L.) Extract on Sleep Deprivation-Induced Oxidative Stress, Cytokine Dysregulation, and Behavioural Changes in Wistar Rats

Current Issues in Molecular Biology, Год журнала: 2025, Номер 47(6), С. 399 - 399

Опубликована: Май 28, 2025

Sleep deprivation (SD) induces significant neurobiological changes, including oxidative stress, neuroinflammation, and behavioural impairments. This study was designed as a proof of concept to assess the potential for modulating effects SD through short-term seven-day administration Cornus mas (C. mas) in rapid eye movement (REM) rodent paradigm. Adult male Wistar rats were randomised four groups (n = 7): control, C. (CM), sleep (SD), with (SD + CM). Behaviourally, induced hyperactivity hyperlocomotion. determined histological alterations prefrontal cortex corpus callosum myelin coupled ultrastructural mitochondrial cellular abnormalities cortex, hippocampus, pineal gland. Despite evidence systemic stress decreased serum GABA BDNF following SD, no changes observed redox markers or inflammatory cytokine levels (TNF-α, IL-1β) within hippocampus. extract has shown an overall modest modulatory action, mainly evidenced on behavioural, histological, parameters. Taken together, these findings highlight region-specific molecular structural prolonged REM rats.

Язык: Английский

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New Insights into Contradictory Changes in Brain-Derived Neurotrophic Factor (BDNF) in Rodent Models of Posttraumatic Stress Disorder (PTSD)

Neurochemical Research, Год журнала: 2024, Номер 49(12), С. 3226 - 3243

Опубликована: Сен. 16, 2024

Язык: Английский

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