International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11171 - 11171
Опубликована: Сен. 22, 2022
Metabolomics
is
a
fundamental
approach
to
discovering
novel
biomarkers
and
their
potential
use
for
precision
medicine.
When
applied
population
screening,
NMR-based
metabolomics
can
become
powerful
clinical
tool
in
oncology.
Urine
tests
be
more
widely
accepted
due
intrinsic
non-invasiveness.
Our
review
provides
the
first
exhaustive
evaluation
of
NMR
determination
colorectal
cancer
(CRC)
urine.
A
specific
search
PubMed,
Web
Science,
Scopus
was
performed,
10
studies
met
required
criteria.
There
were
no
restrictions
on
query
study
type,
leading
not
only
samples
versus
control
comparisons,
but
also
prospective
surgical
effects.
With
this
review,
all
compounds
included
merged
into
database.
In
doing
so,
we
identified
up
100
urine
samples,
11
found
at
least
three
articles.
Results
analyzed
groups:
case
(CRC
adenomas)/control,
pre-/post-surgery,
combining
both
groups.
case-control
pre-/post-surgery
groups,
twelve
relevant.
Seven
down-regulated
metabolites
CRC
identified,
creatinine,
4-hydroxybenzoic
acid,
acetone,
carnitine,
d-glucose,
hippuric
l-lysine,
l-threonine,
pyruvic
up-regulated
acetic
phenylacetylglutamine,
urea.
The
pathways
enrichment
analysis
returned
two
significantly
expressed:
pyruvate
metabolism
glycolysis/gluconeogenesis
pathway.
cases,
acid
(down-regulated
patients,
with
cell
proliferation
effect
tissue)
(up-regulated
chemoprotective
effect)
present.
Drugs,
Год журнала:
2022,
Номер
82(12), С. 1251 - 1276
Опубликована: Авг. 1, 2022
Acute
pancreatitis
is
a
common
indication
for
hospital
admission,
increasing
in
incidence,
including
children,
pregnancy
and
the
elderly.
Moderately
severe
acute
with
fluid
and/or
necrotic
collections
causes
substantial
morbidity,
disease
persistent
organ
failure
significant
mortality.
The
diagnosis
requires
two
of
upper
abdominal
pain,
amylase/lipase
≥
3
×upper
limit
normal,
cross-sectional
imaging
findings.
Gallstones
ethanol
predominate
while
hypertriglyceridaemia
drugs
are
notable
among
many
causes.
Serum
triglycerides,
full
blood
count,
renal
liver
function
tests,
glucose,
calcium,
transabdominal
ultrasound,
chest
indicated,
if
there
diagnostic
uncertainty.
Subsequent
undertaken
to
detect
complications,
example,
C-reactive
protein
exceeds
150
mg/L,
or
rarer
aetiologies.
Pancreatic
intracellular
calcium
overload,
mitochondrial
impairment,
inflammatory
responses
critical
pathogenesis,
targeted
current
treatment
trials,
which
crucially
important
as
no
internationally
licenced
drug
treat
prevent
complications.
Initial
priorities
intravenous
resuscitation,
analgesia,
enteral
nutrition,
when
necessary,
care
support,
parenteral
antibiotics,
pancreatic
exocrine
endocrine
replacement
therapy;
all
may
have
adverse
effects.
Patients
local
complications
should
be
referred
specialist
tertiary
centres
guide
further
management,
include
drainage
necrosectomy.
impact
can
devastating,
so
prevention
reduction
risk
recurrence
progression
chronic
an
increased
pancreas
cancer
proactive
management
that
long
term
some
patients.
Biology of Sex Differences,
Год журнала:
2022,
Номер
13(1)
Опубликована: Июнь 15, 2022
Abstract
Background
The
sexual
dimorphism
represents
one
of
the
triggers
metabolic
disparities
between
organisms,
advising
about
wild
implications
in
research
or
diagnostics
contexts.
Despite
mounting
recognition
importance
sex
consideration
biomedical
fields,
identification
male-
and
female-specific
signatures
has
not
been
achieved.
Main
body
This
review
pointed
focus
on
differences
related
to
sex,
evidenced
by
metabolomics
studies
performed
healthy
populations,
with
leading
aim
understanding
how
influences
baseline
metabolome.
main
shared
apparent
dissimilarities
males
females
were
extracted
highlighted
from
metabolome
most
commonly
analyzed
biological
fluids,
such
as
serum,
plasma,
urine.
Furthermore,
influence
age
significant
interactions
have
taken
into
account.
Conclusions
patterns
human
defined
diverse
biofluids.
detection
sex-
age-related
individuals
are
helpful
for
translational
applications
bench
bedside
set
targeted
diagnostic
prevention
approaches
context
personalized
medicine.
Graphical
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 3, 2024
Early-stage
disease
detection,
particularly
in
Point-Of-Care
(POC)
wearable
formats,
assumes
pivotal
role
advancing
healthcare
services
and
precision-medicine.
Public
benefits
of
early
detection
extend
beyond
cost-effectively
promoting
outcomes,
to
also
include
reducing
the
risk
comorbid
diseases.
Technological
advancements
enabling
POC
biomarker
recognition
empower
discovery
new
markers
for
various
health
conditions.
Integration
wearables
with
intelligent
frameworks
represents
ground-breaking
innovations
automation
operations,
conducting
advanced
large-scale
data
analysis,
generating
predictive
models,
facilitating
remote
guided
clinical
decision-making.
These
substantially
alleviate
socioeconomic
burdens,
creating
a
paradigm
shift
diagnostics,
revolutionizing
medical
assessments
technology
development.
This
review
explores
critical
topics
recent
progress
development
1)
systems
solutions
physiological
monitoring,
as
well
2)
discussing
current
trends
adoption
smart
technologies
within
settings
developing
biological
assays,
ultimately
3)
exploring
utilities
platforms
discovery.
Additionally,
translation
from
research
labs
broader
applications.
It
addresses
associated
risks,
biases,
challenges
widespread
Artificial
Intelligence
(AI)
integration
diagnostics
systems,
while
systematically
outlining
potential
prospects,
challenges,
opportunities.
Magnetic Resonance in Chemistry,
Год журнала:
2023,
Номер
61(12), С. 628 - 653
Опубликована: Апрель 3, 2023
Metabolomics
samples
like
human
urine
or
serum
contain
upwards
of
a
few
thousand
metabolites,
but
individual
analytical
techniques
can
only
characterize
hundred
metabolites
at
best.
The
uncertainty
in
metabolite
identification
commonly
encountered
untargeted
metabolomics
adds
to
this
low
coverage
problem.
A
multiplatform
(multiple
techniques)
approach
improve
upon
the
number
reliably
detected
and
correctly
assigned.
This
be
further
improved
by
applying
synergistic
sample
preparation
along
with
use
combinatorial
sequential
non-destructive
destructive
techniques.
Similarly,
peak
detection
strategies
that
employ
multiple
probabilistic
approaches
have
led
better
annotation
decisions.
Applying
these
also
addresses
issues
reproducibility
found
single
platform
methods.
Nevertheless,
analysis
large
data
sets
from
disparate
presents
unique
challenges.
While
general
processing
workflow
is
similar
across
platforms,
many
software
packages
are
fully
capable
types
instrument.
Traditional
statistical
methods
such
as
principal
component
were
not
designed
handle
multiple,
distinct
sets.
Instead,
multivariate
requires
multiblock
other
model
for
understanding
contribution
instruments.
review
summarizes
advantages,
limitations,
recent
achievements
metabolomics.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Апрель 25, 2024
The
significance
of
point-of-care
testing
(POCT)
in
early
clinical
diagnosis
and
personalized
patient
care
is
increasingly
recognized
as
a
crucial
tool
reducing
disease
outbreaks
improving
survival
rates.
Within
the
realm
POCT,
biosensors
utilizing
magnetic
nanoparticles
(MNPs)
have
emerged
subject
substantial
interest.
This
review
aims
to
provide
comprehensive
evaluation
current
landscape
emphasizing
its
growing
within
practice.
Subsequently,
status
combination
MNPs
Biological
detection
has
been
presented.
Furthermore,
it
delves
into
specific
domain
MNP-based
biosensors,
assessing
their
potential
impact
on
POCT.
By
combining
existing
research
spotlighting
pivotal
discoveries,
this
enhances
our
comprehension
advancements
promising
prospects
offered
by
context
It
seeks
facilitate
informed
decision-making
among
healthcare
professionals
researchers
while
also
promoting
further
exploration
field
study.
Metabolites,
Год журнала:
2023,
Номер
13(1), С. 67 - 67
Опубликована: Янв. 1, 2023
Metabolomics
is
one
of
the
most
promising
‘omics’
sciences
for
implementation
in
medicine
by
developing
new
diagnostic
tests
and
optimizing
drug
therapy.
Since
metabolomics,
end
products
biochemical
processes
an
organism
are
studied,
which
under
influence
both
genetic
environmental
factors,
metabolomics
analysis
can
detect
any
changes
associated
with
lifestyle
pathological
processes.
Almost
every
case-controlled
study
shows
a
high
accuracy.
Taking
into
account
that
already
described
nosologies,
there
prerequisites
high-speed
comprehensive
metabolite
will
replace,
near
future,
narrow
range
chemical
analyses
used
today,
medical
community.
However,
despite
perspectives
personalized
currently
no
FDA-approved
tests.
The
well-known
problem
complexity
data
their
interpretation
end-users,
addition
to
traditional
need
analytical
methods
address
quality
control,
standardization,
treatment
reported
review.
Possible
ways
solve
problems
change
situation
introduction
clinical
practice,
also
discussed.
Future Journal of Pharmaceutical Sciences,
Год журнала:
2024,
Номер
10(1)
Опубликована: Янв. 5, 2024
Abstract
Background
Personalized
or
Precision
medicine
(PM)
is
a
promising
approach
for
the
cancer
treatment
that
tailors
to
patient's
characteristics.
Biomarkers
are
crucial
identifying
patients
who
expected
derive
greatest
advantage
from
targeted
therapy.
Main
body
Here,
various
biomarkers,
including
genetic,
epigenetic,
protein,
and
metabolites,
their
clinical
significance,
discussed.
The
review
provides
insights
into
use
of
biomarkers
significance
in
treatment.
There
several
hurdles
PM
oncology,
such
as
complexity
tumor
biology
heterogeneity,
limited
availability
high
cost
therapies,
resistance
ethical
social
issues.
Conclusion
play
diagnostic
role
cancer.
also
acknowledges
challenges
limitations
personalized
which,
if
resolved,
can
be
helpful
management
