This
PhD
thesis,
entitled
"Holographic
biosensors
made
of
DNA-functionalised
hydrogels
for
in
vitro
diagnostics",
focuses
on
the
development
an
analyte-sensitive
hydrogel,
functionalised
with
oligonucletide
probes,
a
diffractive
structure
as
optical
transducer
diagnostic
applications.The
first
chapter
includes
overview
different
concepts
related
to
biosensing,
recent
developments
diagnostics
market
and,
particular,
DNA
biosensors.In
addition,
synthesis
and
characterization
hydrogels,
their
role
support
matrix
immobilization
strategies
are
presented.Finally,
basic
holography
new
detection
strategy
diffraction
gratings
biosensing
explained.Next,
Chapter
2,
objectives
this
project
discussed.The
aim
research
is
LIST
OF
PUBBLICATIONS
European Journal of Organic Chemistry,
Год журнала:
2024,
Номер
27(42)
Опубликована: Июль 30, 2024
Abstract
A
scalable
protocol
for
direct
SO
2
F
‐based
fluorosulfonylation
of
saturated
(hetero)cyclic
and
functionalized
amines
is
reported.
The
method
cost‐effective
applicable
multigram
preparation
structurally
diverse
compounds,
as
illustrated
by
the
synthesis
58
building
blocks
decorated
with
common
functional
groups.
comparison
overall
yields
products
demonstrates
advantages
present
over
alternative
approaches.
obtained
sp
3
‐enriched
sulfamoyl
fluorides
can
be
considered
a
new
generation
SuFEx
(sulfur
fluoride
exchange)
chemistry.
synthetic
utility
synthesized
was
demonstrated
late‐stage
reactions
tolerating
functionality
well
transformations
to
provide
corresponding
sulfamide,
sulfamate,
sulfonamide
derivatives.
This
PhD
thesis,
entitled
"Holographic
biosensors
made
of
DNA-functionalised
hydrogels
for
in
vitro
diagnostics",
focuses
on
the
development
an
analyte-sensitive
hydrogel,
functionalised
with
oligonucletide
probes,
a
diffractive
structure
as
optical
transducer
diagnostic
applications.The
first
chapter
includes
overview
different
concepts
related
to
biosensing,
recent
developments
diagnostics
market
and,
particular,
DNA
biosensors.In
addition,
synthesis
and
characterization
hydrogels,
their
role
support
matrix
immobilization
strategies
are
presented.Finally,
basic
holography
new
detection
strategy
diffraction
gratings
biosensing
explained.Next,
Chapter
2,
objectives
this
project
discussed.The
aim
research
is
LIST
OF
PUBBLICATIONS
