Basic & Clinical Pharmacology & Toxicology,
Год журнала:
2021,
Номер
130(2), С. 288 - 300
Опубликована: Ноя. 27, 2021
Although
no
gold
standard
exists
to
assess
a
patient's
anticholinergic
burden,
review
identified
19
burden
scales
(ABSs).
No
study
has
yet
evaluated
whether
high
measured
with
all
ABSs
is
associated
in-hospital
mortality
and
length
of
stay
(LOS).
We
conducted
cohort
at
Swiss
tertiary
teaching
hospital
using
patients'
electronic
health
record
data
from
2015-2018.
Included
were
patients
aged
≥65
years,
hospitalised
≥48
h
without
stays
>24
in
intensive
care.
Patients'
cumulative
score
was
classified
binary
(<3:
low,
≥3:
high)
categorical
approach
(0:
no,
0.5-3:
high).
In-hospital
LOS
analysed
multivariable
logistic
linear
regression,
respectively.
included
27,092
(mean
age
78.0
±
7.5
median
6
days).
Of
them,
913
died.
Depending
on
the
ABS,
1370
17,035
exposed
anticholinergics.
Patients
by
1.32-
3.03-fold
increase
compared
those
no/low
burden.
obtained
similar
results
for
LOS.
To
conclude,
discontinuing
drugs
properties
(score
≥3)
admission
might
be
targeted
intervention
decrease
Older
adults
are
susceptible
to
anticholinergic
effects.
Dysphagia
and
pneumonia
associated
with
usage,
though
a
definitive
causative
relationship
has
not
been
established.
There
is
no
effective
way
predict
the
prognosis
of
older
pneumonia;
therefore,
this
study
investigates
predictive
value
burden.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 22, 2024
Abstract
Older
adults
are
frequently
exposed
to
medicines
with
systemic
anticholinergic
properties,
which
linked
increased
risk
of
negative
health
outcomes.
The
association
between
anticholinergics
and
lung
function
has
not
been
reported.
aim
this
study
was
investigate
if
exposure
influences
in
older
adults.
Participants
the
southernmost
centres
Swedish
National
on
Aging
Care
(SNAC)
were
followed
from
2001
2021.
In
total,
2936
subjects
(2253
Good
Skåne
683
SNAC-B)
included.
An
extensive
medical
examination
including
spirometry
assessments
performed
during
visits.
burden
described
using
cognitive
scale.
effect
new
use
annual
change
forced
expiratory
volume
(FEV1s)
estimated
mixed
models.
During
follow-up,
802
(27.3%)
participants
at
least
one
medicine.
On
average,
FEV1s
without
decreased
37.2
ml/year
(95%
CI
[33.8;
40.6])
while
low
high
lose
47.2
[42.4;
52.0])
43.7
[25.4;
62.0]).
A
novel
properties
accelerated
decrease
found.
is
comparable
that
observed
smokers.
Studies
needed
further
explore
potential
side
anticholinergics.
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(8), С. 6921 - 6921
Опубликована: Апрель 7, 2023
Cholinergic
antagonists
interfere
with
synaptic
transmission
in
the
central
nervous
system
and
are
involved
pathological
processes
patients
neurocognitive
disorders
(NCD),
such
as
behavioral
psychological
symptoms
of
dementia
(BPSD).
In
this
commentary,
we
will
briefly
review
current
knowledge
on
impact
cholinergic
burden
BPSD
persons
NCD,
including
main
pathophysiological
mechanisms.
Given
lack
clear
consensus
regarding
symptomatic
management
BPSD,
special
attention
must
be
paid
to
preventable,
iatrogenic
condition
de-prescription
should
considered
BPSD.
British Journal of Clinical Pharmacology,
Год журнала:
2022,
Номер
88(11), С. 4915 - 4927
Опубликована: Июнь 8, 2022
A
recent
review
identified
19
anticholinergic
burden
scales
(ABSs)
but
no
study
has
yet
compared
the
impact
of
all
ABSs
on
delirium.
We
evaluated
whether
a
high
as
classified
by
each
ABS
is
associated
with
incident
delirium.We
performed
retrospective
cohort
in
Swiss
tertiary
teaching
hospital
using
data
from
2015-2018.
Included
were
patients
aged
≥65,
hospitalised
≥48
hours
stay
>24
intensive
care.
Delirium
was
defined
twofold:
(i)
ICD-10
or
CAM
and
(ii)
DOSS.
Patients'
cumulative
score,
calculated
within
24
after
admission,
binary
(<3:
low,
≥3:
burden)
categorical
approach
(0:
no,
0.5-3:
burden).
Association
analysed
multivariable
logistic
regression.Over
25
000
(mean
age
77.9
±
7.6
years)
included.
Of
these,
864
(3.3%)
2770
(11.0%)
developed
Depending
ABS,
4-63%
exposed
to
at
least
one
drug.
Out
ABSs,
14
16
showed
significant
association
outcomes.
patient
score
had
odds
ratios
(ORs)
1.21
(95%
confidence
interval
[CI]:
1.03-1.42)
2.63
CI:
2.28-3.03)
for
delirium
those
low
burden.A
admission
significantly
Although
prospective
studies
need
confirm
these
results,
discontinuing
substituting
drugs
≥3
might
be
targeted
intervention
reduce
Basic & Clinical Pharmacology & Toxicology,
Год журнала:
2021,
Номер
130(2), С. 288 - 300
Опубликована: Ноя. 27, 2021
Although
no
gold
standard
exists
to
assess
a
patient's
anticholinergic
burden,
review
identified
19
burden
scales
(ABSs).
No
study
has
yet
evaluated
whether
high
measured
with
all
ABSs
is
associated
in-hospital
mortality
and
length
of
stay
(LOS).
We
conducted
cohort
at
Swiss
tertiary
teaching
hospital
using
patients'
electronic
health
record
data
from
2015-2018.
Included
were
patients
aged
≥65
years,
hospitalised
≥48
h
without
stays
>24
in
intensive
care.
Patients'
cumulative
score
was
classified
binary
(<3:
low,
≥3:
high)
categorical
approach
(0:
no,
0.5-3:
high).
In-hospital
LOS
analysed
multivariable
logistic
linear
regression,
respectively.
included
27,092
(mean
age
78.0
±
7.5
median
6
days).
Of
them,
913
died.
Depending
on
the
ABS,
1370
17,035
exposed
anticholinergics.
Patients
by
1.32-
3.03-fold
increase
compared
those
no/low
burden.
obtained
similar
results
for
LOS.
To
conclude,
discontinuing
drugs
properties
(score
≥3)
admission
might
be
targeted
intervention
decrease
