Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis DOI Creative Commons
Lulu Cheng, Jianxin Zhang, Hongyu Xi

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 14, 2024

Previous neuroimaging studies have revealed structural and functional brain abnormalities in patients with cervical spondylosis (CS). However, the results are divergent inconsistent. Therefore, present study conducted a multi-modal meta-analysis to investigate consistent alterations CS patients. A comprehensive literature search was five databases retrieve relevant resting-state magnetic resonance imaging (rs-fMRI), MRI diffusion tensor (DTI) that measured differences between healthy controls (HCs). Separate multimodal meta-analyses were implemented, respectively, by employing Anisotropic Effect-size Signed Differential Mapping software. 13 rs-fMRI used regional homogeneity, amplitude of low-frequency fluctuations (ALFF) fractional ALFF, seven voxel-based morphometry (VBM) one DTI finally included research. no on surface-based (SBM) analysis this Due insufficient number SBM studies, only VBM conducted. The showed compared HCs, demonstrated decreased spontaneous activities right lingual gyrus, middle temporal gyrus (MTG), left inferior parietal postcentral (PoCG), while increased medial superior frontal bilateral precuneus. detected GMV (STG) paracentral lobule (PCL), supplementary motor area MTG together activity PoCG, STG PCL among This had significant activity. altered regions mainly primary visual cortex, default mode network sensorimotor area, which may be associated patients' symptoms sensory deficits, blurred vision, cognitive impairment dysfunction. findings contribute understanding underlying pathophysiology dysfunction provide references for early diagnosis treatment CS. https://www.crd.york.ac.uk/PROSPERO/, CRD42022370967.

Язык: Английский

Abnormalities of brain structure and function in cervical spondylosis: a multi-modal voxel-based meta-analysis DOI Creative Commons
Lulu Cheng, Jianxin Zhang, Hongyu Xi

и другие.

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Июнь 14, 2024

Previous neuroimaging studies have revealed structural and functional brain abnormalities in patients with cervical spondylosis (CS). However, the results are divergent inconsistent. Therefore, present study conducted a multi-modal meta-analysis to investigate consistent alterations CS patients. A comprehensive literature search was five databases retrieve relevant resting-state magnetic resonance imaging (rs-fMRI), MRI diffusion tensor (DTI) that measured differences between healthy controls (HCs). Separate multimodal meta-analyses were implemented, respectively, by employing Anisotropic Effect-size Signed Differential Mapping software. 13 rs-fMRI used regional homogeneity, amplitude of low-frequency fluctuations (ALFF) fractional ALFF, seven voxel-based morphometry (VBM) one DTI finally included research. no on surface-based (SBM) analysis this Due insufficient number SBM studies, only VBM conducted. The showed compared HCs, demonstrated decreased spontaneous activities right lingual gyrus, middle temporal gyrus (MTG), left inferior parietal postcentral (PoCG), while increased medial superior frontal bilateral precuneus. detected GMV (STG) paracentral lobule (PCL), supplementary motor area MTG together activity PoCG, STG PCL among This had significant activity. altered regions mainly primary visual cortex, default mode network sensorimotor area, which may be associated patients' symptoms sensory deficits, blurred vision, cognitive impairment dysfunction. findings contribute understanding underlying pathophysiology dysfunction provide references for early diagnosis treatment CS. https://www.crd.york.ac.uk/PROSPERO/, CRD42022370967.

Язык: Английский

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