Bacteriocin production facilitates nosocomial emergence of vancomycin-resistant Enterococcus faecium

Nature Microbiology, Год журнала: 2025, Номер unknown

Опубликована: Март 21, 2025

Gastrointestinal colonization by the nosocomial pathogen vancomycin-resistant Enterococcus faecium (VREfm) can lead to bloodstream infections with high mortality rates. Shifts in VREfm lineages found within healthcare settings occur, but reasons underlying these changes are not understood. Here we sequenced 710 clinical isolates collected between 2017 and 2022 from a large tertiary care centre. Genomic analyses revealed polyclonal population, although 46% of formed genetically related clusters, suggesting transmission rate. Comparing data global collection 15,631 publicly available genomes 2002 identified replacement sequence type (ST) 17 lineage emergent ST80 ST117 at local level. Comparative genomic functional that encoded bacteriocin T8, which conferred competitive advantage over T8-negative strains vitro upon mouse gut. Bacteriocin T8 carriage was also strongly associated strain emergence genome collection. These suggest T8-mediated competition may have contributed replacement. healthcare-associated reveal is enriched provides vivo.

Язык: Английский

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Unlocking the potential of ecofriendly guardians for biological control of plant diseases, crop protection and production in sustainable agriculture

3 Biotech, Год журнала: 2025, Номер 15(4)

Опубликована: Март 9, 2025

Язык: Английский

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Pyocins and Beyond: Exploring the World of Bacteriocins in Pseudomonas aeruginosa

Probiotics and Antimicrobial Proteins, Год журнала: 2024, Номер unknown

Опубликована: Июль 18, 2024

Язык: Английский

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Don’t Judge a Sausage by Its Cover: Effects of Inoculating Three Indigenous Lactic Acid Bacteria on Quality, Moisture Distribution, and Protein Structure in Fermentation

Fermentation, Год журнала: 2025, Номер 11(3), С. 134 - 134

Опубликована: Март 11, 2025

To produce products with standardized and optimal technical performance, probiotics, particularly Lactic Acid Bacteria (LAB), have long been utilized as fermentation starters in sausages, ensuring both the standardization enhancement of product quality safety. Microorganisms isolated from traditional meat products, due to their excellent adaptability environment ability preserve desirable flavor, exhibit high potential candidates for starters. Three indigenous LAB strains—Latilactobacillus sakei, Pediococcus pentosaceus, Weissella cibaria, Yunnan ham—were applied beef sausages investigate underlying factors responsible changes. The results indicated that fermented L. sakei P. pentosaceus exhibited lowest pH (4.98) aw (0.79), while displaying significantly higher hardness, cohesiveness, chewiness. Additionally, LF-NMR measurements showed promoted transfer immobilized water free water, facilitating drying maturation process. Raman spectroscopy analysis revealed a reduction α-helix content an increase disordered β-sheet β-turn structures secondary protein structure. These findings suggest improved attributes by modifying structure enhance migration accelerate ripening demonstrated technological characteristics, indicating efficacy use sausage production. This study provides valuable insights into improving production using specific strains.

Язык: Английский

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Metabolic profiling, antibacterial effects, and preservation mechanisms of Paenibacillus provencensis metabolites in refrigerated Sea Bass (Perca fluviatilis)

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106493 - 106493

Опубликована: Апрель 1, 2025

Язык: Английский

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Bacteriocin Isolated from Ralstonia mannitolilytica and Bacteriocin-Capped Silver Nanoparticles: Comparative Effects on Biofilm Formation and LuxS Gene’s Expressions by Proteus mirabilis as an Approach to Counter MDR Catheter Infection

Microbial Pathogenesis, Год журнала: 2025, Номер unknown, С. 107558 - 107558

Опубликована: Апрель 1, 2025

Язык: Английский

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The in vitro studies combined with molecular docking and MM-GBSA binding free energy calculations reveal broad-spectrum antibacterial activity of bacteriocin from curd-derived Limosilactobacillus fermentum with probiotic attributes

Опубликована: Апрель 1, 2025

Язык: Английский

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Food, Health, and Environmental Impact of Lactic Acid Bacteria: The Superbacteria for Posterity

Probiotics and Antimicrobial Proteins, Год журнала: 2025, Номер unknown

Опубликована: Апрель 28, 2025

Язык: Английский

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A genome-wide One Health study of Klebsiella pneumoniae in Norway reveals overlapping populations but few recent transmission events across reservoirs

Genome Medicine, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 28, 2025

Язык: Английский

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The Impact of Bioactive Molecules from Probiotics on Child Health: A Comprehensive Review

Nutrients, Год журнала: 2024, Номер 16(21), С. 3706 - 3706

Опубликована: Окт. 30, 2024

: This review investigates the impact of bioactive molecules produced by probiotics on child health, focusing their roles in modulating gut microbiota, enhancing immune function, and supporting overall development. Key metabolites, including short-chain fatty acids (SCFAs), bacteriocins, exopolysaccharides (EPSs), vitamins, gamma-aminobutyric acid (GABA), are highlighted for ability to maintain regulate inflammation, support neurodevelopment.

Язык: Английский

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