Bacterial homologs of innate eukaryotic antiviral defenses with anti-phage activity highlight shared evolutionary roots of viral defenses

Cell Host & Microbe, Год журнала: 2024, Номер 32(8), С. 1427 - 1443.e8

Опубликована: Авг. 1, 2024

Язык: Английский

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Nucleotides and nucleotide derivatives as signal molecules in plants

Journal of Experimental Botany, Год журнала: 2024, Номер 75(22), С. 6918 - 6938

Опубликована: Сен. 9, 2024

Abstract In reaction to a stimulus, signaling molecules are made, generate response, and then degraded. Nucleotides classically associated with central metabolism nucleic acid biosynthesis, but there number of nucleotides nucleotide derivatives in plants which this simple definition molecule applies whole or at least part. These include cytokinins chloroplast guanosine tetraposphate (ppGpp), as well extracellular canonical such ATP (eATP) NAD+ (eNAD+). addition, is series compounds derived from ADP ribose (ADPR), ATP–ADPR dinucleotides their hydrolysis products (e.g. pRib-AMP) together different variants cyclic ADPR (cADPR, 2´-cADPR, 3´-cADPR), also 3´,5´-cAMP 2´,3´-cyclic nucleoside monophosphates. Interestingly, some these have recently been shown play role pathogen defense. review, we highlight exciting new developments. We review that considered candidates for molecules, example purine deoxynucleosides, discuss more controversial cases.

Язык: Английский

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NLR we there yet? Nucleocytoplasmic coordination of NLR‐mediated immunity

New Phytologist, Год журнала: 2022, Номер 236(1), С. 24 - 42

Опубликована: Июль 7, 2022

Summary Plant intracellular nucleotide‐binding leucine‐rich repeat immune receptors (NLRs) perceive the activity of pathogen‐secreted effector molecules that, when undetected, promote colonisation hosts. Signalling from activated NLRs converges with and potentiates downstream responses pattern recognition (PRRs) that sense microbial signatures at cell surface. Efficient signalling both receptor branches relies on host nucleus as an integration point for transcriptional reprogramming, macromolecular transport processes mediate communication between cytoplasm nucleoplasm. Studies nuclear pore complexes (NPCs), nucleoporin proteins (NUPs) compose NPCs, machinery constituents control nucleocytoplasmic transport, have revealed they play important roles in regulating plant responses. Here, we discuss contributions nucleoporins (NTR)‐mediated signal transduction immunity emphasis NLR across compartment boundary within nucleus. We also highlight cytoplasmic functions their partners further consider potential implications activation resistosome formation cellular compartments mediating pathogen resistance programmed death.

Язык: Английский

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Toll/interleukin-1 receptor domains in bacterial and plant immunity

Current Opinion in Microbiology, Год журнала: 2023, Номер 74, С. 102316 - 102316

Опубликована: Апрель 20, 2023

Язык: Английский

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Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2022, Номер unknown

Опубликована: Апрель 1, 2022

Abstract Plant nucleotide-binding leucine-rich-repeat receptors (NLRs) with an N-terminal toll/interleukin-1 receptor (TIR) domain sense pathogen effectors to enable TIR-encoded NADase activity for immune signaling. TIR-NLR (TNL) signaling requires conserved helper NLRs NRG1 and ADR1 the lipase-like protein EDS1 that functions as a heterodimer each of its paralogs PAD4 SAG101. We show TIR-containing proteins catalyze production 2’-(5’’-phosphoribosyl)-5’-adenosine mono-/di-phosphate (pRib-AMP/ADP) in vitro planta . Biochemical structural data demonstrate EDS1-PAD4 is complex pRib-AMP/ADP. pRib-ADP binding triggers conformational change C-terminal allosterically promote interaction ADR1-L1 but not NRG1A. Our study identifies TIR-catalyzed pRib-AMP/ADP missing link TIR via likely second messengers plant immunity.

Язык: Английский

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