Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 26, 2024
Epithelial
cells
form
a
resilient
barrier
and
orchestrate
defensive
reparative
mechanisms
to
maintain
tissue
stability.
This
review
focuses
on
gut
airway
epithelia,
which
are
positioned
where
the
body
interfaces
with
outside
world.
We
many
signaling
pathways
by
epithelial
at
interface
respond
invading
pathogens
mount
an
innate
immune
response
initiate
adaptive
immunity
communicate
other
cells,
including
resident
microbiota,
heal
damaged
homeostasis.
compare
contrast
how
detect
pathogens,
release
antimicrobial
effectors,
collaborate
macrophages,
Tregs
stem
repair.
also
describe
advanced
research
models
for
studying
communication
behaviors
during
inflammation,
injury
disease.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 7, 2025
Tomato
yellow
leaf
curl
virus
(TYLCV),
a
major
plant
virus,
infects
multiple
species,
severely
threatening
global
food
security.
Arbutin,
natural
product
used
in
cosmetics
to
reduce
pigmentation,
also
exhibits
antibacterial
and
anti-inflammatory
properties.
However,
its
potential
protection
remains
undocumented.
This
study
reveals
arbutin's
ability
inhibit
TYLCV
infection.
In
Nicotiana
benthamiana,
100
μg/mL
arbutin
inhibited
viral
gene
accumulation
by
up
76.8%,
surpassing
ningnanmycin
(65.8%)
ribavirin
(39.5%).
Besides,
microscale
thermophoresis
indicated
that
bound
strongly
the
coat
protein
(CP).
Molecular
docking
interacted
with
ARG58,
VAL65,
CYS69.
RT-qPCR
Western
blot
experiments
confirmed
crucial
roles
of
these
amino
acids,
especially
Transcriptome
analysis
revealed
mutating
VAL65
affected
plant–pathogen
interaction
pathways
MAPK
signaling
host
defense
mechanisms.
unveils
novel
antiviral
function,
providing
insights
for
developing
new
biopesticides
against
viruses.
Biochemical Journal,
Год журнала:
2025,
Номер
482(05), С. 275 - 294
Опубликована: Март 1, 2025
The
concept
of
higher-order
assembly
signalling
or
by
co-operative
formation
(SCAF)
was
proposed
based
on
the
structures
assemblies
formed
proteins
featuring
domains
from
death-fold
family
and
Toll/interleukin-1
receptor
domain
family.
Because
these
form
filamentous
upon
stimulation
activate
downstream
pathways
through
induced
proximity,
they
were
envisioned
to
sharpen
response
thresholds
extreme
co-operativity
assembly.
Recent
findings
demonstrate
that
a
central
feature
SCAF
mechanism
is
nucleation
barrier
allows
switch-like,
digital
'all-or-none'
minute
stimuli.
In
agreement,
this
features
in
cell-death
innate
immunity
activation
where
binary
decision
required.
Here,
we
broaden
encapsulate
essential
kinetic
properties
open-ended
signalling,
compare
other
such
as
biomolecular
condensates,
review
how
operates
cells.
New Phytologist,
Год журнала:
2022,
Номер
236(1), С. 24 - 42
Опубликована: Июль 7, 2022
Summary
Plant
intracellular
nucleotide‐binding
leucine‐rich
repeat
immune
receptors
(NLRs)
perceive
the
activity
of
pathogen‐secreted
effector
molecules
that,
when
undetected,
promote
colonisation
hosts.
Signalling
from
activated
NLRs
converges
with
and
potentiates
downstream
responses
pattern
recognition
(PRRs)
that
sense
microbial
signatures
at
cell
surface.
Efficient
signalling
both
receptor
branches
relies
on
host
nucleus
as
an
integration
point
for
transcriptional
reprogramming,
macromolecular
transport
processes
mediate
communication
between
cytoplasm
nucleoplasm.
Studies
nuclear
pore
complexes
(NPCs),
nucleoporin
proteins
(NUPs)
compose
NPCs,
machinery
constituents
control
nucleocytoplasmic
transport,
have
revealed
they
play
important
roles
in
regulating
plant
responses.
Here,
we
discuss
contributions
nucleoporins
(NTR)‐mediated
signal
transduction
immunity
emphasis
NLR
across
compartment
boundary
within
nucleus.
We
also
highlight
cytoplasmic
functions
their
partners
further
consider
potential
implications
activation
resistosome
formation
cellular
compartments
mediating
pathogen
resistance
programmed
death.
Frontiers in Cellular and Infection Microbiology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 26, 2024
Epithelial
cells
form
a
resilient
barrier
and
orchestrate
defensive
reparative
mechanisms
to
maintain
tissue
stability.
This
review
focuses
on
gut
airway
epithelia,
which
are
positioned
where
the
body
interfaces
with
outside
world.
We
many
signaling
pathways
by
epithelial
at
interface
respond
invading
pathogens
mount
an
innate
immune
response
initiate
adaptive
immunity
communicate
other
cells,
including
resident
microbiota,
heal
damaged
homeostasis.
compare
contrast
how
detect
pathogens,
release
antimicrobial
effectors,
collaborate
macrophages,
Tregs
stem
repair.
also
describe
advanced
research
models
for
studying
communication
behaviors
during
inflammation,
injury
disease.
