Cited by Dynamics of T-cell responses following COVID-19 mRNA vaccination and breakthrough infection in older adults

Dynamics of T-cell responses following COVID-19 mRNA vaccination and breakthrough infection in older adults DOI

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Июль 16, 2023

ABSTRACT Introduction While older adults generally mount weaker antibody responses to a primary COVID-19 vaccine series, T-cell remain less well characterized in this population. We compared SARS-CoV-2 spike-specific after two- and three-dose mRNA vaccination subsequent breakthrough infection younger adults. Methods quantified CD4+ CD8+ T-cells reactive overlapping peptides spanning the ancestral spike protein 40 (median age 79) 50 health care workers 39), all naive, using an activation induced marker assay. were further assessed 24 participants, including 8 adults, who subsequently experienced their first infection. Results A third dose significantly boosted frequencies above two-dose levels did not differ between either dose. Multivariable analyses adjusting for sociodemographic, vaccine-related variables confirmed that was associated with impaired cellular responses. Instead, strongest predictors of post-third-dose corresponding post-second-dose frequencies. Breakthrough increased both T cell frequencies, comparable Exploratory revealed association HLA-A*02:03 higher post-vaccination which may be attributable numerous strong-binding HLA-A*02:03-specific epitopes spike. Conclusion Older robust vaccination, are following

Язык: Английский

HLA-DQ2/8 and COVID-19 in Celiac Disease: Boon or Bane DOI

Aaron Lerner, Carina Benzvi, Aristo Vojdani

и другие.

Microorganisms, Год журнала: 2023, Номер 11(12), С. 2977 - 2977

Опубликована: Дек. 13, 2023

The SARS-CoV-2 pandemic continues to pose a global threat. While its virulence has subsided, it persisted due the continual emergence of new mutations. Although many high-risk conditions related COVID-19 have been identified, understanding protective factors remains limited. Intriguingly, epidemiological evidence suggests low incidence COVID-19-infected CD patients. present study explores whether their genetic background, namely, associated HLA-DQs, offers protection against severe outcomes. We hypothesize that HLA-DQ2/8 alleles may shield patients from and subsequent effects, possibly memory CD4 T cells primed by previous exposure human-associated common cold coronaviruses (CCC) higher affinity those allele's groove. In this context, we examined potential cross-reactivity between epitopes CCC assessed binding (BA) these HLA-DQ2/8. Using computational methods, analyzed sequence similarity four distinct CCC. Of 924 unique immunodominant 15-mer with at least 67% identity, 37 exhibited significant BA HLA-DQ2/8, suggesting effect. various mechanisms might explain role in COVID-19-afflicted If substantiated, insights could enhance our gene-environment enigma viral-host relationship, guiding therapeutic innovations ongoing pandemic.

Язык: Английский

Процитировано

A Single Nucleotide Variant in Ankyrin-2 Influencing Ventricular Tachycardia in COVID-19 Associated Myocarditis DOI

E.L. Haase, Chandana Kulkarni, Peyton Moore

и другие.

Cardiogenetics, Год журнала: 2024, Номер 14(2), С. 84 - 92

Опубликована: Май 6, 2024

Introduction: This paper explores the potential influence of a single nucleotide variant in ANK-2 gene on COVID-19 myocarditis-related ventricular tachycardia. Case Description: A 53-year-old female with history Crohn’s disease and asthma developed COVID-19. Shortly after infection, she experienced symptoms chest pressure, palpitations, shortness breath, leading to eventual diagnosis myocarditis complicated by recurrent Treatment mechanistically driven anti-arrhythmic therapy beta-blockers suppressed this highly symptomatic Genetic testing further risk stratify long term care identified gene, which is known be associated arrhythmic risk. Discussion: case study highlights use rationally selected therapy, mexiletine, management tachycardia presence ANK-2, raising possibility its contribution VT susceptibility severity. Our patient demonstrated significant improvement administered therapeutics, including resolution The normalization QT interval during phase supports genetic potassium channel activity.

Язык: Английский

Процитировано

HLA-C Peptide Repertoires as Predictors of Clinical Response during Early SARS-CoV-2 Infection DOI

Michael D. Olp, Vincent A. Laufer, Andrew L. Valesano

и другие.

Life, Год журнала: 2024, Номер 14(9), С. 1181 - 1181

Опубликована: Сен. 19, 2024

The human leukocyte antigen (HLA) system plays a pivotal role in the immune response to viral infections, mediating presentation of peptides T cells and influencing both strength specificity host response. Variations HLA genotypes across individuals lead differences susceptibility infection severity illness. This study uses observations from early phase COVID-19 pandemic explore how specific class I molecules affect clinical responses SARS-CoV-2 infection. By analyzing paired high-resolution types genomic sequences 60 patients, we assess relationship between predicted peptide binding repertoires as measured by sequential organ failure assessment score. approach leverages functional convergence HLA-C alleles identify relationships that may otherwise be inaccessible due allelic diversity limitations sample size. Surprisingly, our findings show severely symptomatic this cohort is associated with disproportionately abundant structural non-structural protein epitopes patient molecules. In addition, extent overlap given patient’s HLA-A correlates worse prognoses cohort. highlight immunologic mechanisms linking pathogens warrant further investigation.

Язык: Английский

Процитировано

Immunogenetics special issue 2023: Immunogenetics of infectious disease DOI