International Journal of Frontiers in Medicine,
Год журнала:
2024,
Номер
6(5)
Опубликована: Янв. 1, 2024
In
recent
years,
genetic
engineering
technology
has
become
an
indispensable
key
in
the
field
of
biopharmaceutical.
Genetic
can
significantly
improve
production
efficiency
and
efficacy
drugs
by
manipulating
modifying
genes.
This
paper
analyzes
application
biopharmaceutical,
introduces
its
successful
cases,
discusses
great
value
first
summarizes
classification
development
biopharmaceutical
field,
then
principle
method
detail.
Then
specific
is
analyzed.
Finally,
prospect
prospected.
With
continuous
progress
improvement
regulations,
will
certainly
bring
revolutionary
changes
to
benefit
human
health.
Molecules,
Год журнала:
2022,
Номер
27(10), С. 3054 - 3054
Опубликована: Май 10, 2022
Never
has
the
world
been
more
challenged
by
respiratory
diseases
(RDs)
than
it
witnessed
in
last
few
decades.
This
is
evident
plethora
of
acute
and
chronic
conditions,
ranging
from
asthma
obstructive
pulmonary
disease
(COPD)
to
multidrug-resistant
tuberculosis,
pneumonia,
influenza,
recently,
novel
coronavirus
(COVID-19)
disease.
Unfortunately,
emergence
drug-resistant
strains
pathogens,
drug
toxicity
side
effects
are
drawbacks
effective
chemotherapeutic
management
RDs;
hence,
our
focus
on
natural
sources
because
their
unique
chemical
diversities
therapeutic
applications.
review
provides
a
summary
some
common
RDs,
strategies,
prospect
plant-derived
products
search
for
new
drugs
against
diseases.
Advanced NanoBiomed Research,
Год журнала:
2022,
Номер
3(2)
Опубликована: Дек. 22, 2022
The
highly
multidrug‐resistant
(MDR)
Gram‐negative
bacterial
pathogen
Acinetobacter
baumannii
is
a
top
global
health
priority
where
an
effective
vaccine
can
protect
susceptible
populations
and
limit
resistance
acquisition.
Outer
membrane
vesicles
(OMVs)
shed
from
bacteria
are
enriched
with
virulence
factors
lipids
but
heterogeneous
in
size
cargo.
Herein,
platform
combining
precise
replicable
nanoparticle
technology
immunogenic
A.
OMVs
(Ab‐OMVs)
reported.
Gold
cores
coated
Ab‐OMVs
(Ab‐NPs)
induce
robust
IgG
titers
rabbits
that
enhance
human
neutrophil
opsonophagocytic
killing
passively
against
lethal
sepsis
mice.
Active
Ab‐NP
immunization
mice
protects
pneumonia,
accompanied
by
B
cell
recruitment
to
draining
lymph
nodes,
activation
of
dendritic
markers,
improved
splenic
responses,
mitigation
proinflammatory
cytokine
storm.
Nanoparticles
efficient
efficacious
for
OMV
delivery
perhaps
other
high‐priority
MDR
pathogens.
Biomolecules,
Год журнала:
2023,
Номер
13(11), С. 1565 - 1565
Опубликована: Окт. 24, 2023
The
Coronavirus
disease-2019
(COVID-19),
caused
by
the
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
has
significantly
impacted
health
and
socioeconomic
status
of
humans
worldwide.
Pulmonary
infection
SARS-CoV-2
results
in
exorbitant
viral
replication
associated
onset
inflammatory
cytokine
storm
disease
pathology
various
internal
organs.
However,
etiopathogenesis
is
not
fully
understood.
Currently,
there
are
no
targeted
therapies
available
to
cure
COVID-19,
most
patients
treated
empirically
with
anti-inflammatory
and/or
anti-viral
drugs,
based
on
symptoms.
Although
several
types
vaccines
currently
implemented
control
COVID-19
prevent
dissemination,
emergence
new
variants
that
can
evade
vaccine-induced
protective
immunity
poses
challenges
current
vaccination
strategies
highlights
necessity
develop
better
improved
vaccines.
In
this
review,
we
summarize
elaborately
discuss
strategies,
focusing
those
use
worldwide
combat
or
stages
clinical
development
humans.
Pathogens,
Год журнала:
2023,
Номер
13(1), С. 38 - 38
Опубликована: Дек. 31, 2023
Developing
a
safe
and
effective
vaccine
against
the
hepatitis
C
virus
(HCV)
remains
top
priority
for
global
health.
Despite
recent
advances
in
antiviral
therapies,
high
cost
limited
accessibility
of
these
treatments
impede
their
widespread
application,
particularly
resource-limited
settings.
Therefore,
development
HCV
necessity.
This
review
article
analyzes
current
technologies,
future
prospects,
strategies,
genomic
targets,
governmental
role
development.
We
discuss
epidemiological
landscape
infection
potential
structural
non-structural
protein
antigens
as
targets.
In
addition,
involvement
government
agencies
policymakers
supporting
facilitating
vaccines
is
emphasized.
explore
how
regulatory
channels
frameworks
affect
research
goals,
funding,
public
health
policy.
The
significance
international
public-private
partnerships
accelerating
an
examined.
Finally,
directions
developing
are
discussed.
conclusion,
highlights
urgent
need
preventive
to
fight
disease
collaborative
efforts
between
scientists,
politicians,
organizations
reach
this
important
goal.
International Journal of Frontiers in Medicine,
Год журнала:
2024,
Номер
6(5)
Опубликована: Янв. 1, 2024
In
recent
years,
genetic
engineering
technology
has
become
an
indispensable
key
in
the
field
of
biopharmaceutical.
Genetic
can
significantly
improve
production
efficiency
and
efficacy
drugs
by
manipulating
modifying
genes.
This
paper
analyzes
application
biopharmaceutical,
introduces
its
successful
cases,
discusses
great
value
first
summarizes
classification
development
biopharmaceutical
field,
then
principle
method
detail.
Then
specific
is
analyzed.
Finally,
prospect
prospected.
With
continuous
progress
improvement
regulations,
will
certainly
bring
revolutionary
changes
to
benefit
human
health.
