Metabolic bone imaging and its relationship with biomechanics DOI Creative Commons
Ananya Goyal, Lauren E. Watkins, Olivia L. Bruce

и другие.

Osteoarthritis Imaging, Год журнала: 2024, Номер 4(3), С. 100242 - 100242

Опубликована: Июль 13, 2024

This mini review delves into the mechanisms of [18F]Sodium Fluoride positron emission tomography ([18F]NaF PET), which, by interrogating areas newly mineralizing bone, provides a valuable tool to study joint response loading and altered whole-joint function in osteoarthritis (OA). The consolidates discusses findings from both preclinical clinical studies that utilize [18F]NaF PET evaluate bone various paradigms. It also briefly reviews technical considerations for imaging its strong potential as quest understand metabolism context osteoarthritis. While considering previous studies, new applications this methodology are discussed. PET/MRI reveals localized, load-related responses after exercise, providing insights early OA progression. In human significant increases tracer uptake observed affected pathology, driven perfusion blood volume. Future work examine relationship between metabolic exercise environment is needed. Integrating with advanced biomechanical modeling holds promise guiding management OA, primarily examining soft tissues joint, forces.

Язык: Английский

Introduction to the International Skeletal Society 50-Year Anniversary Special Issue—50 years of labor, adaptation, and success DOI

Thomas M. Link,

William E. Palmer, Ali Guermazi

и другие.

Skeletal Radiology, Год журнала: 2024, Номер 53(9), С. 1665 - 1666

Опубликована: Июнь 29, 2024

Язык: Английский

Процитировано

0
Metabolic bone imaging and its relationship with biomechanics DOI Creative Commons
Ananya Goyal, Lauren E. Watkins, Olivia L. Bruce

и другие.

Osteoarthritis Imaging, Год журнала: 2024, Номер 4(3), С. 100242 - 100242

Опубликована: Июль 13, 2024

This mini review delves into the mechanisms of [18F]Sodium Fluoride positron emission tomography ([18F]NaF PET), which, by interrogating areas newly mineralizing bone, provides a valuable tool to study joint response loading and altered whole-joint function in osteoarthritis (OA). The consolidates discusses findings from both preclinical clinical studies that utilize [18F]NaF PET evaluate bone various paradigms. It also briefly reviews technical considerations for imaging its strong potential as quest understand metabolism context osteoarthritis. While considering previous studies, new applications this methodology are discussed. PET/MRI reveals localized, load-related responses after exercise, providing insights early OA progression. In human significant increases tracer uptake observed affected pathology, driven perfusion blood volume. Future work examine relationship between metabolic exercise environment is needed. Integrating with advanced biomechanical modeling holds promise guiding management OA, primarily examining soft tissues joint, forces.

Язык: Английский

Процитировано

0