CRYAB is upregulated and predicts clinical prognosis in kidney renal clear cell carcinoma
IUBMB Life,
Год журнала:
2025,
Номер
77(1)
Опубликована: Янв. 1, 2025
Abstract
Clear
cell
renal
carcinoma
(KIRC)
is
the
most
prevalent
subtype
of
(RCC),
accounting
for
70%
to
80%
all
RCC
cases.
The
CRYAB
(αB‐crystallin)
gene
broadly
expressed
across
various
human
tissues,
yet
its
role
in
KIRC
progression
remains
unclear.
This
study
aims
elucidate
function
and
assess
potential
as
a
biomarker
early
diagnosis,
therapeutic
targeting,
prognosis.
In
our
report,
we
found
that
was
dramatically
upregulated
KIRC,
expression
associated
with
TNM
stage,
pathological
age.
Also,
patients
higher
exhibited
poor
survival
overexpression
led
enhanced
tumor
proliferation.
Vice
versa,
downregulation
resulted
decreased
proliferation
vitro.
Mechanistically,
Gene
set
enrichment
analysis
plots
showed
survival.
Consistently,
these
effects
were
increased
AKT
signaling
BCL‐2
expression.
Furthermore,
also
observed
levels
negatively
correlated
immunocyte
infiltration.
conclusion,
findings
suggested
could
be
regarded
latent
Язык: Английский
Sex as modifier of survival in patients with advanced urothelial cancer treated with pembrolizumab
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Март 14, 2025
Gender-
and
sex-based
disparities
in
response
to
immune-checkpoint
inhibitors
(ICI)
has
been
reported
a
variety
of
tumor
types.
Women
have
different
anatomy
with
recurrent
urinary
tract
infections,
sex
hormonal
profile,
intrinsic
differences
local
systemic
immune
systems
urobiome
composition.
Existing
literature
data
pan-cancer
context
reveal
contradictory
results,
real-world
evidence
urothelial
carcinoma
(UC)
is
lacking.
This
was
real-world,
multicenter,
international,
observational
study
determine
the
effects
on
clinical
outcomes
metastatic
(mUC)
patients
progressing
or
recurring
after
platinum-based
therapy
treated
pembrolizumab
as
part
routine
care.
A
total
1039
patients,
from
January
1st,
2016
December
31st,
2023
68
cancer
centers
were
included.
Our
showed
that
women
had
shorter
OS
than
men,
13%
advantage
5-year
rate
for
male
patients.
deeper
understanding
these
results
may
inform
sex-stratification
future
prospective
trials
help
develop
strategies
reduce
magnitude
observed
outcomes.
Язык: Английский
Overlooked and underserved: how healthcare fails men in the pursuit of equity
Current Opinion in Urology,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 27, 2024
Purpose
of
review
Men
face
distinctive
health-related
challenges
as
a
result
biological,
behavioral,
and
sociocultural
factors.
In
addition,
the
modern
healthcare
system
does
not
offer
men
equal
opportunities
options
to
ensure
sex-specific
access
delivery
health
services.
Men's
concerns
are,
indeed,
often
addressed
or
even
forgotten.
this
review,
we
wanted
assess
impact
biology
effects
on
life-expectancy.
Recent
findings
Globally,
have
shorter
life
expectancy
than
women.
With
5.8
years
gender
gap
in
USA
5.4
EU-27
(both
2022).
Cardiovascular
disease,
cancer,
accidents
continue
represent
primary
causes
mortality
for
both
genders
with
all
having
disproportional
preponderance
men.
recent
years,
there
has
been
notable
decline
age-adjusted
rates
related
while
an
increase
deaths
from
accidental
intentional
self-harm.
Moreover,
United
States,
are
more
likely
women
develop
die
nonsex-specific
cancers.
As
result,
men's
poor
affects
productivity,
absenteeism,
employment.
Summary
The
status
is
complex.
It
rooted
history,
culture,
institutions.
To
address
disparities,
need
comprehensive
approach
that
includes
policy
reforms,
changes,
fair
equitable
public
discourse.
Grassroots
top-down
strategies
needed
value-based
societal
acknowledging
unique
needs
Язык: Английский