In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution DOI Open Access

Valentina Dal Col,

Cassiano Marchi,

Fabio Ribas

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen elastin synthesis. This study evaluates the comparative potential of CaHA conventional saline dilution versus mixed with poly-micronutrient solution (CaHA/PMN) to enhance biostimulatory effects. In an vitro model, primary human fibroblasts were treated both formulations, cell viability gene expression type I collagen, elastin, FOXO3, SIRT-1, SIRT-3 assessed. The results demonstrated that CaHA/PMN treatments significantly improved cellular responses compared control. outperformed CaHA, greater increases viability, synthesis, SIRT-3, FOXO3. These findings suggest poly-micronutrient-enriched solutions can CaHA's regenerative potential, providing promising approach skin rejuvenation elasticity improvement.

Язык: Английский

Exosome Revolution or Marketing Mirage? AI-Based Multi-domain Evaluation of Claims, Scientific Evidence, Transparency, Public Sentiment, and Media Narratives DOI
Eqram Rahman, Karim Sayed,

Parinitha Rao

и другие.

Aesthetic Plastic Surgery, Год журнала: 2025, Номер unknown

Опубликована: Март 7, 2025

Язык: Английский

Процитировано

0
In Vitro Comparative Study of Calcium Hydroxyapatite (Stiim): Conventional Saline Dilution Versus Poly-Micronutrient Dilution DOI Open Access

Valentina Dal Col,

Cassiano Marchi,

Fabio Ribas

и другие.

Cureus, Год журнала: 2025, Номер unknown

Опубликована: Март 10, 2025

Calcium hydroxylapatite (CaHA) is widely used in aesthetics for its dual role as a dermal filler and biostimulator, promoting collagen elastin synthesis. This study evaluates the comparative potential of CaHA conventional saline dilution versus mixed with poly-micronutrient solution (CaHA/PMN) to enhance biostimulatory effects. In an vitro model, primary human fibroblasts were treated both formulations, cell viability gene expression type I collagen, elastin, FOXO3, SIRT-1, SIRT-3 assessed. The results demonstrated that CaHA/PMN treatments significantly improved cellular responses compared control. outperformed CaHA, greater increases viability, synthesis, SIRT-3, FOXO3. These findings suggest poly-micronutrient-enriched solutions can CaHA's regenerative potential, providing promising approach skin rejuvenation elasticity improvement.

Язык: Английский

Процитировано

0