Immunotherapy time of infusion impacts survival in head and neck cancer: A propensity score matched analysis

Oral Oncology, Год журнала: 2024, Номер 151, С. 106761 - 106761

Опубликована: Март 20, 2024

Язык: Английский

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Macrophage Meets the Circadian Clock: Implication of the Circadian Clock in the Role of Macrophages in Acute Lower Respiratory Tract Infection

Frontiers in Cellular and Infection Microbiology, Год журнала: 2022, Номер 12

Опубликована: Фев. 23, 2022

The circadian rhythm is a biological system that creates daily variations of physiology and behavior with 24-h cycle, which precisely controlled by the molecular clock. clock dominates temporal activity physiological homeostasis at level, including endocrine secretion, metabolic, immune response, coupled extrinsic environmental cues ( e.g. , light/dark cycles) behavioral sleep/wake cycles feeding/fasting cycles). other side misaligned contributes to onset variety diseases, such as cancer, metabolic cardiovascular acceleration aging, development systemic inflammation. role played macrophages key mediator between disruption At macrophage functions are under direct control clock, thus misalignment remodels phenotype toward ‘killer’ mode. Remarkably, inflammatory induce chronic inflammation, leading diseases dampened defensive machinery against infectious COVID-19. Here, we discuss how regulates provide potential risk rhythms diseases.

Язык: Английский

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The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development

Cell Communication and Signaling, Год журнала: 2025, Номер 23(1)

Опубликована: Янв. 16, 2025

The complex interaction between circadian rhythms and physiological functions is essential for maintaining human health. At the heart of this lies PERIOD proteins (PERs), pivotal to clock, influencing timing behavioral processes impacting oxidative stress, immune functionality, tumorigenesis. PER1 orchestrates cooperation enzyme GPX1, modulating mitochondrial dynamics in sync with daily thus regulating mechanisms managing energy substrates. PERs innate cells modulate temporal patterns NF-κB TNF-α activities, as well response LPS-induced toxic shock, initiating inflammatory responses that escalate into chronic conditions. Crucially, cancer cell behaviors including proliferation, apoptosis, migration by levels cycle stimulating expression oncogenes c-Myc MDM2. PER2/3, antagonists stem biology, play important roles differentiating their stemness. Importantly, Pers serve a significant factor early diagnosis prognosis. This review delves link rhythm regulator PERs, disruptions rhythm, oncogenesis. We examine evidence highlights how dysfunctions activities initiate development, aid tumor growth, modify metabolism through pathways involved stress system. Comprehending these connections opens new development rhythm-based therapeutic strategies, aims boosting enhancing treatments.

Язык: Английский

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Time to start taking time seriously: how to investigate unexpected biological rhythms within infectious disease research

Philosophical Transactions of the Royal Society B Biological Sciences, Год журнала: 2025, Номер 380(1918)

Опубликована: Янв. 23, 2025

The discovery of rhythmicity in host and pathogen activities dates back to the Hippocratic era, but causes consequences these biological rhythms have remained poorly understood. Rhythms infection phenotypes or traits are observed across taxonomically diverse hosts pathogens, suggesting general evolutionary principles. Understanding principles may enable be leveraged manners that improve drug vaccine efficacy disrupt timekeeping reduce virulence transmission. Explaining exploiting infections require an integrative multidisciplinary approach, which is a hallmark research within chronobiology. Many researchers welcomed into chronobiology from other fields after observing unexpected rhythm time-of-day effect their data. Such findings can launch rich new topic, engaging with concepts, approaches dogma discipline daunting. Fortunately, has well-developed frameworks for interrogating readily applied novel contexts. Here, we provide ‘how to’ guide exploring daily infectious disease research. We outline how establish: whether circadian, what extent responsible, relevance host–pathogen interactions, explore therapeutic potential. This article part Theo Murphy meeting issue ‘Circadian immunity’.

Язык: Английский

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Overall survival according to time-of-day of combined immuno-chemotherapy for advanced non-small cell lung cancer: a bicentric bicontinental study

EBioMedicine, Год журнала: 2025, Номер 113, С. 105607 - 105607

Опубликована: Фев. 20, 2025

Язык: Английский

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Chrono-optimizing vaccine administration: a systematic review and meta-analysis

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Апрель 7, 2025

Increasing evidence suggests that vaccine responses may vary based on the time of day administration. This systematic review provides a comprehensive overview impact vaccination timing immune responses, to assess its potential role in optimizing programs. A literature search was performed Embase, Medline and Scopus identify eligible observational studies clinical trials assessed following at different times humans. meta-analysis conducted quantify effect size antibody responses. The identified 17 compared day, covering vaccinations against COVID-19 (9), influenza (5), hepatitis B (2), (1), pneumococcal infection (1). Eleven out these demonstrated statistically significant effects response, with 10 reporting stronger morning afternoon vaccination. Of six subgroups an average age 60 years older, five showed significantly vaccination, while sixth only men. In contrast, 16 younger than titers. Similarly, indicated receiving elicited response (SMD = 0.24, 95% CI 0.01-0.47), subgroup analyses revealing larger adults aged 65 older 0.32, 0.21-0.43) those or 0.00, -0.17-0.17). Morning enhanced key demographic for Chrono-optimizing administration offer low-risk, low-cost strategy boost effectiveness this group. https://inplasy.com/inplasy-2025-1-0060/.

Язык: Английский

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Circadian Oscillation of Leukocyte Subpopulations and Inflammatory Cytokines over a 24-H Period in Horses

Veterinary Sciences, Год журнала: 2025, Номер 12(4), С. 386 - 386

Опубликована: Апрель 20, 2025

The objective of the present study was to investigate influence daily rhythms on immune and inflammatory systems in horses, considering white blood cell count (WBCs), leukocyte subpopulations (neutrophils, basophils, eosinophils, lymphocytes, monocytes), CD4+, CD8+ lymphocyte populations, interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α). Ten Italian Saddle horses (7–12 years old, body weight 480 ± 30 kg) underwent sampling every 4 h over a 24-h period. COSINOR method used identify their parameters. A one-way analysis variance (ANOVA) applied differences acrophase robustness, multiple correlation model (Pearson) evaluate relationships among investigated WBCs, subpopulations, CD8+, IL-1β, IL-6, TNFα exhibited rhythmicity. In particular, IL-6 reached acrophases during dark phase, while neuthrophils, showed diurnal acrophase. One-way ANOVA statistical difference parameters (p < 0.0001). Pearson matrix positive negative Circadian should be taken into consideration with fluctuations biomarkers develop good management practices improve welfare horses.

Язык: Английский

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Night-shift work is associated with increased susceptibility to SARS-CoV-2 infection

Chronobiology International, Год журнала: 2022, Номер 39(8), С. 1100 - 1109

Опубликована: Май 2, 2022

Night-shift workers experience disturbances of their circadian rhythm and sleep, which may make them more susceptible to infectious diseases. Therefore, we studied whether night-shift are at higher risk testing positive for SARS-CoV-2 infection than day workers. In this prospective study, data were used from 20 questionnaire rounds the Dutch Lifelines COVID-19 cohort that was initiated in March 2020. different rounds, 2285 23,766 reported they had tested SARS-CoV-2. Cox proportional hazards regression models adjusted demographic, work, health covariates compare incidence between From 2020-January 2021, 3.4% 2.2% have (p < .001). After adjustment covariates, a 37% (hazard ratio: 1.37, 95% confidence interval: 1.05–1.77). show likely test workers, adds growing evidence work influence complex processes involved susceptibility. Further mechanistic insight is needed understand relation (SARS-CoV-2)

Язык: Английский

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Regulation of Cytotoxic CD8+ T Cells by the Circadian Clock

The Journal of Immunology, Год журнала: 2023, Номер 210(1), С. 12 - 18

Опубликована: Янв. 1, 2023

Abstract Most aspects of physiology, including immunity, present 24-h variations called circadian rhythms. In this review, we examine the literature on regulation CD8+ T cells, which are important to fight intracellular infections and tumors. cells express clock genes, ∼6% their transcriptome presents oscillations. cell counts rhythms in blood secondary lymphoid organs, depend these as well hormonal Moreover, strength response Ag presentation varies according time day, a rhythm dependent clock. The relevance is shown by daily infections. Such also has implications for cancer, optimization vaccination immunotherapy.

Язык: Английский

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The Influence of Time of Day of Vaccination with BNT162b2 on the Adverse Drug Reactions and Efficacy of Humoral Response against SARS-CoV-2 in an Observational Study of Young Adults

Vaccines, Год журнала: 2022, Номер 10(3), С. 443 - 443

Опубликована: Март 14, 2022

An increasing body of evidence from both academic and clinical studies shows that time-of-day exposure to antigens might significantly alter modulate the development adaptive immune responses. Considering immense impact COVID-19 pandemic on global health diminished efficacy vaccination in selected populations, such as older immunocompromised patients, it is critical search for most optimal conditions mounting responses against SARS-CoV-2. Hence, we conducted an observational study 435 healthy young adults vaccinated with two doses BNT162b2 (Pfizer-BioNTech) vaccine determine whether influences either magnitude humoral response or number adverse drug reactions (ADR) being reported. We found no significant differences between morning afternoon terms titers anti-Spike antibodies frequency ADR studied population. In addition, our analysis data occurrence 1324 subjects demonstrated second administration those previous SARS-CoV-2 infection was associated lower incidence ADR. aggregate, mRNA presumed generate equally efficient response.

Язык: Английский

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