Correlation between Castelli risk index-I and female infertility: A cross-sectional study DOI Creative Commons
Weijing Yang, Xi Liu, Yan Wang

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Июнь 3, 2025

The association between metabolic syndrome and female reproductive health has garnered increasing attention; however, the relationship Castelli risk index I (CRI-I, total cholesterol/high-density lipoprotein cholesterol ratio) infertility remains unclear. This study was designed to explore potential CRI-I infertility. population derived from data collected in three consecutive two-year cycles (2013-2018) of National Health Nutrition Examination Survey (NHANES), ultimately including 2,629 participants aged 18-45 years. Weighted multivariable logistic regression models were used assess following adjustment for covariates such as demographic characteristics, medical history, lifestyle factors, among others. Restricted cubic spline threshold effect analyses conducted examine possible nonlinear associations. Subgroup ROC curves robustness predictive capacity. scores significantly elevated infertile group comparison with non-infertile (median [interquartile range, IQR]: 3.38 [2.77-4.07] vs. 3.08 [2.53-3.80]; P = 0.001). showed a positive monotonic risk, each unit increase corresponding 17% higher likelihood (adjusted OR 1.17, 95% CI: 1.01-1.36; 0.042). Nonlinear analysis identified (inflection point 3.73): increased when < 3.73 (OR 1.54, 1.20-1.98), whereas attenuated above this threshold. revealed significant interaction by hypertension status (interaction 0.05). demonstrated modest utility (AUC 0.580, 0.548-0.613). Elevated positively associated infertility, particularly specific subgroups (e.g., younger, married, non-hypertensive, or alcohol-consuming individuals). These findings underscore role dysregulated lipid metabolism dysfunction.

Язык: Английский

Correlation between Castelli risk index-I and female infertility: A cross-sectional study DOI Creative Commons
Weijing Yang, Xi Liu, Yan Wang

и другие.

Lipids in Health and Disease, Год журнала: 2025, Номер 24(1)

Опубликована: Июнь 3, 2025

The association between metabolic syndrome and female reproductive health has garnered increasing attention; however, the relationship Castelli risk index I (CRI-I, total cholesterol/high-density lipoprotein cholesterol ratio) infertility remains unclear. This study was designed to explore potential CRI-I infertility. population derived from data collected in three consecutive two-year cycles (2013-2018) of National Health Nutrition Examination Survey (NHANES), ultimately including 2,629 participants aged 18-45 years. Weighted multivariable logistic regression models were used assess following adjustment for covariates such as demographic characteristics, medical history, lifestyle factors, among others. Restricted cubic spline threshold effect analyses conducted examine possible nonlinear associations. Subgroup ROC curves robustness predictive capacity. scores significantly elevated infertile group comparison with non-infertile (median [interquartile range, IQR]: 3.38 [2.77-4.07] vs. 3.08 [2.53-3.80]; P = 0.001). showed a positive monotonic risk, each unit increase corresponding 17% higher likelihood (adjusted OR 1.17, 95% CI: 1.01-1.36; 0.042). Nonlinear analysis identified (inflection point 3.73): increased when < 3.73 (OR 1.54, 1.20-1.98), whereas attenuated above this threshold. revealed significant interaction by hypertension status (interaction 0.05). demonstrated modest utility (AUC 0.580, 0.548-0.613). Elevated positively associated infertility, particularly specific subgroups (e.g., younger, married, non-hypertensive, or alcohol-consuming individuals). These findings underscore role dysregulated lipid metabolism dysfunction.

Язык: Английский

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