Journal of Inorganic and Organometallic Polymers and Materials, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
ACS Applied Nano Materials, Год журнала: 2024, Номер 7(5), С. 5272 - 5286
Опубликована: Фев. 21, 2024
Superparamagnetic nanoparticle-arrested hydrogel matrices have immense significance in smart soft biomaterials. Herein, we report the synthesis of superparamagnetic nanoparticle-loaded magneto-responsive tough elastomeric hydrogels for dual-responsive drug delivery. In first phase work, carried out room-temperature amine-functionalized iron oxide nanoparticles (IONPs), and second demonstrated that IONPs could act as a toughening agent well viscosity modifier poly(acrylic acid-co-hydroxyethyl methacrylate) copolymer hydrogels. The was tested by Fourier transformed infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), continuous-wave-electron paramagnetic resonance (CW-EPR). Moreover, affect its gelation time elasticity significantly, which also evaluated from rheological behavior. compressive mechanical strength (∼120 kPa), elasticity, recovery to original shape (zero permanent set), water uptake, thixotropic behavior under dynamic stress hybrid supported robustness swelled state. release showed dual parameter dependency (IONPs cross-linker) responsiveness against both pH static magnetic field. delayed network rupturing, delivery nature, noncytotoxic human live cells promote this an ideal alternative remotely controlled vehicle.
Язык: Английский
Процитировано
43
Case Studies in Chemical and Environmental Engineering, Год журнала: 2024, Номер 10, С. 100831 - 100831
Опубликована: Июль 1, 2024
This synthesis aimed to obtain a highly stable, biodegradable, biocompatible, and swellable superabsorbent hydrogel that is ecofriendly. A new method of preparation nanocomposite based on Castor plant leaves within swelling networks developed. Therefore, Sodium Alginate-g-Poly (Itaconic acid-co-Sodium 4-Styrenesulfonate)/Castor leaves, (SA-g-P(ITA-co-NaSS)/CPL) was prepared by free radical copolymerization using potassium persulfate (KPS) as an initiator N,N-methylene bisacrylamide (MBA) cross-linker in aqueous solutions. Characterization the surface has been done Fourier-transform infrared spectroscopy (FTIR) shown all functional groups for (SA-g-P(ITA-co-NaSS)/CPL), field emission scanning electron microscopy (FESEM) displayed smooth, wrinkled versus hydrogel's rough irregular surface. BG-loaded exhibited sheet-like morphology, spherical shapes nonhomogeneous distribution, transmission (TEM) confirmed CPL interaction with matrix, evidenced dark regions, Energy dispersive X-Ray (EDX) analysis performed investigate elemental composition nanocomposite, X-ray diffraction (XRD) pattern matrix disappear hydrogel., thermogravimetric (TGA) determine thermal stability synthesized represented complete breakdown at 600–750 °C, Brunauer− Emmett−Teller (BET) shows specific area total pore volume 0.019 cm3 g−1. The effect onto Brilliant Green (BG) dye removal, exerted via adsorbent through electrostatic interactions, hydrogen bonds. Under optimal conditions (Co = 700 mg. L−1, pH 7, t 1 h, wt. 0.05 g T 25 °C), maximum adsorption efficiency BG 1260.34 higher uptake capacity resulting efficiencies above 75–95 % across broad spectrum initial concentrations, solution, temperatures. Thus, after 1h equilibrium time, it used saturation adsorbate Freundlich isotherm models pseudo-second order kinetic were found be best fitting kinetics data. Thermodynamic parameters show (ΔG < 0) spontaneous (ΔH endothermic. novelty this work being first report supported CPL, investigation its carried out model pollutant molecule, namely dye, mechanisms. promising novel absorbance, proven high up 6 sequential recycles.
Язык: Английский
Процитировано
10
Journal of Molecular Liquids, Год журнала: 2024, Номер 401, С. 124680 - 124680
Опубликована: Апрель 8, 2024
Язык: Английский
Процитировано
5
International Journal of Biological Macromolecules, Год журнала: 2024, Номер 274, С. 133516 - 133516
Опубликована: Июнь 27, 2024
Язык: Английский
Процитировано
5
European Journal of Medicinal Chemistry Reports, Год журнала: 2024, Номер unknown, С. 100231 - 100231
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
4
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 17, 2025
This study aims to synthesize a new localized drug delivery system of bioglass, polyvinyl alcohol (PVA), cellulose (CNC), and sodium alginate (SA) beads as carrier for methotrexate (MTX) drugs the treatment osteosarcoma. Methotrexate /Bioglass-loaded Polyvinyl/Cellulose/Sodium biocomposite were prepared via dropwise method with different concentrations (65%SiO2-30%CaO- 5%P2O5) bioglass. Samples named B0, S0, S1, S2, S3, respectively. Calcium chloride (CaCl2) was used cross-linking agent. The obtained investigated by techniques FTIR, XRD, SEM, etc. bioactivity MTX/BG-loaded PVA-CNC-SA tested immersion in simulated body fluid (SBF). profile release UV-vis spectroscopy 30 days. A cytotoxicity performed human osteosarcoma (MG-63) cell line. Results indicated that formation hydroxyapatite layer on bead's surface confirmed its biological activity. Bioactivity directly proportional BG content. All samples B1, S3 exhibited significant maximum up 6 days controlled gradually. Cytotoxicity results showed high death detected MG-63 cells, (IC-50 ± SD) (116.16 1.57) compared B1 (306.99 2.72) S1 (204.74 4.55) due MTX, which profile. prove can be bioactive, systems, anticancer materials.
Язык: Английский
Процитировано
0
Frontiers in Bioengineering and Biotechnology, Год журнала: 2025, Номер 12
Опубликована: Янв. 17, 2025
Cancer continues to be one of the leading causes death worldwide, and conventional cancer therapies such as chemotherapy, radiation therapy, surgery have limitations. RNA therapy vaccines hold considerable promise an alternative for their ability enable personalized with improved efficacy reduced side effects. The principal approach is induce a specific immune response against cells. However, major challenge in immunotherapy predict which patients will respond treatment monitor vaccine during treatment. Theragnostics, integration diagnostic therapeutic capabilities into single hybrid platform system, has potential address these challenges by enabling real-time monitoring while allowing endogenously controlled adjustments. In this article, we review current state-of-the-art theragnostics including imaging agents, biomarkers, other tools relevant cancer, application development personalization. We also discuss opportunities further clinical translation vaccines.
Язык: Английский
Процитировано
0
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 25, 2025
Abstract Hydroxyapatite (HA) is an important constituent of natural bone. The properties HA can be enhanced with the help various ionic substitutions in crystal lattice HA. Iron (Fe) a vital element present bones and teeth. In this study, iron-doped was synthesized using refluxing-based sol-gel route varying concentrations iron (1–9 M%). Samples were analyzed X-ray diffractometer (XRD), UV–Vis Spectrophotometer, Fourier-transform infrared spectroscopy (FT-IR), vibrating sample magnetometer (VSM) Scanning Electron Microscope (SEM). biological assessment carried out by hemolytic assay, anti-bacterial activity in-vitro biocompatibility. XRD data confirmed evolution hexagonal structure reduction crystallinity crystallite size. All characteristic bands FT-IR which also further proved existence A-type carbonated apatite. spectra band gap energies owing to substitution iron. SEM results showed change shape samples increasing concentration. magnetic behavior altered from diamagnetic ferromagnetic due doping heating efficiency. found hemocompatible. antibacterial efficacy higher for E. coli (gram-negative) bacteria compared S. aureus (gram-positive) bacteria. Moreover, superior cell viability MG-63 (osteoblast-like) cells observed Fe-doped HA, attributed MTT assay revealed osteoblast-like These strongly emphasize potential developed bone regeneration applications.
Язык: Английский
Процитировано
0
Polymers, Год журнала: 2025, Номер 17(3), С. 402 - 402
Опубликована: Фев. 3, 2025
The side effects associated with the chemotherapy of triple-negative breast cancer (TNBC), such as nucleotide-binding oligomerization domain (NOD)-like receptor family (NLR), pyrin containing 3 (NLRP3) inflammasome activity, are responsible for treatment failure and high mortality rates. Therefore, advanced delivery systems have been developed to improve transport targeted administration anti-tumor agents at tumor sites using tissue engineering approaches. Implantable based on biodegradable polymers an effective alternative due biocompatibility, porosity, mechanical strength. Moreover, use paclitaxel (PTX)-cyclodextrin complexes increases solubility permeability PTX, enhancing bioavailability efficacy drug. All these properties contribute efficient encapsulation controlled release drugs, preventing damage healthy tissues. In current study, we detailed synthesis process evaluation 3D scaffolds gelatin functionalized methacryloyl groups (GelMA) pectin loaded PTX–cyclodextrin inclusion TNBC pathogenesis in vitro vivo. Bio-physio-chemical analysis proposed revealed favorable biological cellular component. To drug solubility, a host–guest interaction was performed by complexation PTX cyclodextrin derivative prior scaffold synthesis. presence suppressed growth cells promoted caspase-1 interleukin (IL)-1β, production reactive oxygen species (ROS), conditioning expression levels genes proteins tumorigenesis NLRP3 inflammasome. vivo experiments suggested activation pyroptosis cell death, confirming experiments. conclusion, bio-mechanical GelMA pectin-based well addition allow suppressing viability via death initiation.
Язык: Английский
Процитировано
0
Colloids and Surfaces A Physicochemical and Engineering Aspects, Год журнала: 2025, Номер unknown, С. 136790 - 136790
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0