Functional Materials Letters,
Год журнала:
2024,
Номер
17(07)
Опубликована: Май 23, 2024
To
integrate
pH/NIR
dual-responsive
drug
release
mechanisms
with
multimodal
therapies
for
effective
treatment
of
malignant
tumors,
hierarchical
hydroxyapatite
(HAp)/AuNR
hybrid
microspheres,
consisting
a
hollow
HAp
core
and
an
AuNR
shell,
were
facilely
synthesized
using
phytic
acid
(IP6)
as
sustainable
template
phosphorus
source.
Urea
served
the
pore-forming
agent
pH
regulator
during
synthesis
process.
The
integration
into
multifunctional
systems
enabled
NIR-responsive
controllable
photothermal
ablation
specifically
at
tumorigenic
site.
aggregation
within
outside
microspheres
effectively
hinders
doxorubicin
hydrochloride
(DOX)
from
mitigating
initial
burst
minimizing
side
effects.
results
indicate
that
h-HAp/AuNR
exhibited
remarkable
loading
efficiency
(159.9[Formula:
see
text]g
⋅
mg[Formula:
text]),
exhibiting
pH-dependent
behavior
due
to
dissolution
in
acidic
environments.
Furthermore,
MTT
assays
fluorescence
imaging
demonstrate
DOX-loaded
significantly
enhance
antitumor
efficacy,
achieving
cell
survival
rate
12.3%
concentration
100[Formula:
mL.
This
integrated
system
offers
promising
approach
combined
chemotherapeutic
delivery
NIR
therapy.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2025,
Номер
12
Опубликована: Янв. 17, 2025
Cancer
continues
to
be
one
of
the
leading
causes
death
worldwide,
and
conventional
cancer
therapies
such
as
chemotherapy,
radiation
therapy,
surgery
have
limitations.
RNA
therapy
vaccines
hold
considerable
promise
an
alternative
for
their
ability
enable
personalized
with
improved
efficacy
reduced
side
effects.
The
principal
approach
is
induce
a
specific
immune
response
against
cells.
However,
major
challenge
in
immunotherapy
predict
which
patients
will
respond
treatment
monitor
vaccine
during
treatment.
Theragnostics,
integration
diagnostic
therapeutic
capabilities
into
single
hybrid
platform
system,
has
potential
address
these
challenges
by
enabling
real-time
monitoring
while
allowing
endogenously
controlled
adjustments.
In
this
article,
we
review
current
state-of-the-art
theragnostics
including
imaging
agents,
biomarkers,
other
tools
relevant
cancer,
application
development
personalization.
We
also
discuss
opportunities
further
clinical
translation
vaccines.
Communications Chemistry,
Год журнала:
2024,
Номер
7(1)
Опубликована: Июль 29, 2024
Global
changes
and
drug
abuse
are
forcing
humanity
to
face
various
disease
problems,
alternative
therapies
with
safe
natural
substances
have
important
research
value.
This
paper
combines
techniques
in
quantum
chemical
calculations
molecular
simulations
provide
molecular-level
insight
into
the
dynamics
of
self-assembly
N-isopropylacrylamide
(NIPAM)
for
loading
curcumin
(CUR).
The
results
indicate
that
increasing
chain
length
NIPAM
molecules
reduces
their
efficiency
encapsulating
locking
CUR,
electrostatic
interactions
van
der
Waals
main
driving
forces
behind
evolution
system
configurations
these
processes.
isopropyl
groups
two
phenolic
ring
planes
CUR
contact
areas
interaction
between
types
molecules.
thermosensitive
effect
can
alter
distribution
around
CUR.
As
a
result,
when
temperature
rises
from
ambient
(300
K)
human
characteristic
(310
K),
NIPAM-CUR
radial
functions
suggest
body
is
more
suitable
release.
Our
findings
offer
vital
theoretical
foundation
practical
guidance
researchers
develop
temperature-sensitive
delivery
systems
tailored
addressing
its
clinical
application
bottleneck.
Curcumin
substance
beneficial
pharmacological
properties,
but
poor
solubility,
instability
absorption
hinder
use
as
therapeutic
agent
body.
Here,
authors
explore
release
curcumin.
Functional Materials Letters,
Год журнала:
2024,
Номер
17(07)
Опубликована: Май 23, 2024
To
integrate
pH/NIR
dual-responsive
drug
release
mechanisms
with
multimodal
therapies
for
effective
treatment
of
malignant
tumors,
hierarchical
hydroxyapatite
(HAp)/AuNR
hybrid
microspheres,
consisting
a
hollow
HAp
core
and
an
AuNR
shell,
were
facilely
synthesized
using
phytic
acid
(IP6)
as
sustainable
template
phosphorus
source.
Urea
served
the
pore-forming
agent
pH
regulator
during
synthesis
process.
The
integration
into
multifunctional
systems
enabled
NIR-responsive
controllable
photothermal
ablation
specifically
at
tumorigenic
site.
aggregation
within
outside
microspheres
effectively
hinders
doxorubicin
hydrochloride
(DOX)
from
mitigating
initial
burst
minimizing
side
effects.
results
indicate
that
h-HAp/AuNR
exhibited
remarkable
loading
efficiency
(159.9[Formula:
see
text]g
⋅
mg[Formula:
text]),
exhibiting
pH-dependent
behavior
due
to
dissolution
in
acidic
environments.
Furthermore,
MTT
assays
fluorescence
imaging
demonstrate
DOX-loaded
significantly
enhance
antitumor
efficacy,
achieving
cell
survival
rate
12.3%
concentration
100[Formula:
mL.
This
integrated
system
offers
promising
approach
combined
chemotherapeutic
delivery
NIR
therapy.
