New Onset of Autoimmune Diseases Following COVID-19 Diagnosis

Cells, Год журнала: 2021, Номер 10(12), С. 3592 - 3592

Опубликована: Дек. 20, 2021

There is growing evidence that coronavirus disease 2019 (COVID-19) can lead to a dysregulation of the immune system with development autoimmune phenomena. The consequence this ranges from production autoantibodies onset rheumatic disease. In context, we conducted systematic review analyze current data regarding new-onset systemic and diseases in COVID-19 patients. A literature search PubMed Scopus databases December September 2021 identified 99 patients fulfilled specific diagnostic/classification criteria and/or nomenclature for each main reported were vasculitis arthritis. Idiopathic inflammatory myopathies, lupus erythematosus, sarcoidosis also limited number patients, as well isolated cases sclerosis adult-onset Still's These findings highlight potential spectrum could be precipitated by SARS-CoV-2 infection. Complementary studies are needed discern link between new onset-rheumatic so knowledge used early diagnosis most suitable management.

Язык: Английский

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Risk of autoimmune diseases following COVID-19 and the potential protective effect from vaccination: a population-based cohort study

EClinicalMedicine, Год журнала: 2023, Номер 63, С. 102154 - 102154

Опубликована: Авг. 16, 2023

Case reports suggest that SARS-CoV-2 infection could lead to immune dysregulation and trigger autoimmunity while COVID-19 vaccination is effective against severe outcomes. We aim examine the association between development of autoimmune diseases (ADs), potential protective effect on such an association.A retrospective cohort study was conducted in Hong Kong 1 April 2020 15 November 2022. confirmed by positive polymerase chain reaction or rapid antigen test. Cox proportional hazard regression with inverse probability treatment weighting applied estimate risk incident ADs following COVID-19. vaccinated population compared unvaccinated new ADs.The included 1,028,721 3,168,467 non-COVID individuals. Compared controls, patients presented increased developing pernicious anaemia [adjusted Hazard Ratio (aHR): 1.72; 95% Confidence Interval (CI): 1.12-2.64]; spondyloarthritis [aHR: 1.32 (95% CI: 1.03-1.69)]; rheumatoid arthritis 1.29 1.09-1.54)]; other 1.43 1.33-1.54)]; psoriasis 1.42 1.13-1.78)]; pemphigoid 2.39 1.83-3.11)]; Graves' disease 1.30 1.10-1.54)]; anti-phospholipid antibody syndrome 2.12 1.47-3.05)]; mediated thrombocytopenia 2.1 1.82-2.43)]; multiple sclerosis 2.66 1.17-6.05)]; vasculitis 1.46 1.04-2.04)]. Among patients, completion two doses vaccine shows a decreased pemphigoid, disease, syndrome, immune-mediated thrombocytopenia, systemic lupus erythematosus arthritis.Our findings suggested associated various be attenuated vaccination. Future studies investigating pathology mechanisms would valuable interpreting our findings.Supported RGC Collaborative Research Fund (C7154-20GF).

Язык: Английский

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COVID-19 in Joint Ageing and Osteoarthritis: Current Status and Perspectives

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(2), С. 720 - 720

Опубликована: Янв. 10, 2022

COVID-19 is a trending topic worldwide due to its immense impact on society. Recent trends have shifted from acute effects towards the long-term morbidity of COVID-19. In this review, we hypothesize that SARS-CoV-2 contributes age-related perturbations in endothelial and adipose tissue, which are known characterize early aging process. This would explain long-lasting symptoms as result an accelerated Connective tissues such tissue musculoskeletal primary sites aging. Therefore, current literature was analyzed focusing patients. Hypovitaminosis D, increased fragility, calcium deficiency point bone aging, while joint muscle pain typical for respectively. These characteristics could be classified osteoarthritis-like phenotype. Exploration osteoarthritis well neuronal function, showed similar perturbations. At molecular level, attributed angiotensin-converting enzyme 2 expression, renin-angiotensin system dysfunction, inflammation. Finally, influence nicotinic cholinergic being evaluated new treatment strategy. combined with knowledge pave road

Язык: Английский

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Reactive arthritis before and after the onset of the COVID-19 pandemic

Clinical Rheumatology, Год журнала: 2022, Номер 41(6), С. 1641 - 1652

Опубликована: Март 5, 2022

Язык: Английский

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Post-COVID-19 arthritis: is it hyperinflammation or autoimmunity?

European Cytokine Network, Год журнала: 2021, Номер 32(4), С. 83 - 88

Опубликована: Дек. 1, 2021

Various musculoskeletal and autoimmune manifestations have been described in patients with coronavirus disease 2019 (COVID-19). Objectives: This study aims to investigate the prevalence etiology of arthritis post-COVID Egyptian patients. Methods: We included 100 who recovered 6 months ago assessed several inflammatory markers. Results: The was 37%. Ankle, knee, wrist were most commonly affected joints. Old age (P = 0.010), smoking 0.001), arthralgia 0.049) all linked arthritis. Levels pretreatment (baseline) interleukin (IL)-6 (46.41 ± 3.67 vs. 24.03 2.46; P as well 6-month C-reactive protein (CRP; 98.49 67.55 54.32 65.73; 0.002), erythrocyte sedimentation rate (ESR; 109.08 174.91 58.35 37.87; 0.029) significantly higher compared those without. On other hand, complement C3 0.558) C4 0.192), anti-nuclear antibodies 0.709), anti-cyclic citrullinated peptides (anti-CCP; 0.855) did not show significant differences. Only IL-6 level single predictor an odds ratio (95% confidence interval) 3.988 (1.460-10.892) a P-value 0.007. strong association observed markers (ESR CRP) insignificant serologic autoimmunity (ANA anti-CCP) our support notion that underlying mechanism post-COVID-19 is primarily due hyperinflammatory process associated COVID-19 infection, result reaction. levels before therapy can predict allowing for early management.

Язык: Английский

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Musculoskeletal Manifestations of COVID-19: Currently Described Clinical Symptoms and Multimodality Imaging Findings

Radiographics, Год журнала: 2022, Номер 42(5), С. 1415 - 1432

Опубликована: Июль 22, 2022

COVID-19, the clinical syndrome produced by infection with SARS-CoV-2, can result in multisystem organ dysfunction, including respiratory failure and hypercoagulability, which lead to critical illness death. Musculoskeletal (MSK) manifestations of COVID-19 are common but have been relatively underreported, possibly because severity other systems. Additionally, patients who undergone sedation critically ill often unable alert clinicians their MSK symptoms. Furthermore, some therapeutic measures such as medications vaccinations worsen existing symptoms or cause additional Symptoms may persist occur months after initial infection, known post-COVID condition long COVID. As global experience vaccination effort increases, certain patterns disease involving bones, muscles, peripheral nerves, blood vessels, joints emerged, many likely related a hyperinflammatory host response, prothrombotic state, efforts rather than direct viral toxicity. Imaging findings for various COVID-19-related pathologic conditions across variety modalities being recognized, be helpful diagnosis, treatment guidance, follow-up. The online slide presentation from RSNA Annual Meeting is available this article.©RSNA, 2022.

Язык: Английский

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Reactive arthritis occurring after COVID-19 infection: a narrative review

Infection, Год журнала: 2022, Номер 51(1), С. 37 - 45

Опубликована: Июнь 2, 2022

Язык: Английский

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Concurrent myopathy and inflammatory cardiac disease in COVID-19 patients: a case series and literature review

Rheumatology International, Год журнала: 2022, Номер 42(5), С. 905 - 912

Опубликована: Март 11, 2022

Язык: Английский

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Does post-COVID reactive arthritis exist? Experience of a tertiary care centre with a review of the literature

Reumatología Clínica, Год журнала: 2022, Номер 19(2), С. 67 - 73

Опубликована: Май 12, 2022

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COVID-19-associated arthritis: an emerging new entity?

RMD Open, Год журнала: 2022, Номер 8(2), С. e002026 - e002026

Опубликована: Сен. 1, 2022

The current COVID-19 pandemic raises several clinical challenges. Cases of COVID-19-associated arthritis have been reported, and inconsistently described as either viral or reactive arthritis. We aimed to review all the reported cases ‘COVID-19-associated arthritis’, which we propose, is a better term define entire spectrum new-onset believed be associated with SARS-CoV-2 infection. performed systematic literature using MEDLINE, EMBASE Cochrane Database Systematic Reviews search for articles published up 13 December 2021. included cohort studies, case series reports describing patients diagnosed by physician, irrespective fulfilment classification criteria. To identify relevant medical subject headings keywords related ‘COVID-19/SARS-CoV-2 infection’ ‘reactive arthritis’ were used. Our retrieved 419 articles, 31 in review. A total 33 these majority being adults (28/33=85%) peripheral joint involvement (26/33=79%). Most responded well treatment disease was self-limiting. These describe possible causal relationship between exposure onset However, since during pandemic, other aetiologies cannot fully excluded. exact mechanism through might trigger not understood robust epidemiological data support are still lacking.

Язык: Английский

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