Manganese-derived biomaterials for tumor diagnosis and therapy

Journal of Nanobiotechnology, Год журнала: 2024, Номер 22(1)

Опубликована: Июнь 15, 2024

Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading the emergence of various Mn-based nanomaterials with applications across diverse fields, particularly in tumor diagnosis therapy. Systematic reviews specifically addressing therapy aspects Mn-derived biomaterials are lacking. This review comprehensively explores physicochemical characteristics synthesis methods biomaterials, emphasizing their role diagnostics, including magnetic resonance imaging, photoacoustic photothermal ultrasound multimodal biodetection. Moreover, advantages materials treatment discussed, drug delivery, microenvironment regulation, synergistic photothermal, photodynamic, chemodynamic therapies, immunotherapy, imaging-guided The concludes by providing insights into current landscape future directions for Mn-driven advancements field, serving as a comprehensive resource researchers clinicians.

Язык: Английский

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Late/delayed gadolinium enhancement in MRI after intravenous administration of extracellular gadolinium-based contrast agents: is it worth waiting?

Magnetic Resonance Materials in Physics Biology and Medicine, Год журнала: 2024, Номер 37(2), С. 151 - 168

Опубликована: Фев. 22, 2024

Язык: Английский

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Drug provocation tests (DPTs) of contrast media: Useful or not useful? – A narrative review

World Allergy Organization Journal, Год журнала: 2024, Номер 17(9), С. 100946 - 100946

Опубликована: Авг. 20, 2024

Drug provocation tests (DPTs) are also used in some patients with a history of contrast medium (CM)-hypersensitivity reaction. Since the use agents requires special knowledge that is present radiology but not necessarily allergology, this overview should close gaps. The literature, and package inserts industry dealing DPTs hypersensitivity reactions was analyzed results presented. Historical analyses revealed were already done past, called pre-testing. Due to disadvantages, diagnostic tool abandoned. A few years later, DPT introduced as an innovative procedure. has 3 main disadvantages: missing standardization, at risk (such compromised renal function) rarely taken into account, negative does exclude subsequent CM (formerly pre-testing) well-known method for diagnosing CM-related reactions. disadvantages diagnosis outweigh advantages, we propose replacing routine contrast-enhanced imaging examination radiology.

Язык: Английский

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Phenotyping of COPD with MRI in comparison to same-day CT in a multi-centre trial

European Radiology, Год журнала: 2024, Номер 34(9), С. 5597 - 5609

Опубликована: Фев. 12, 2024

Abstract Objectives A prospective, multi-centre study to evaluate concordance of morphologic lung MRI and CT in chronic obstructive pulmonary disease (COPD) phenotyping for airway emphysema. Methods total 601 participants with COPD from 15 sites underwent same-day morpho-functional chest paired inspiratory-expiratory CT. Two readers systematically scored bronchial wall thickening, bronchiectasis, centrilobular nodules, air trapping parenchyma defects each lobe determined phenotype. third reader acted as adjudicator establish consensus. Inter-modality inter-reader agreement were assessed using Cohen’s kappa (im-κ ir-κ). Results The mean combined score bronchiectasis/bronchial thickening was 4.5/12 (CT scores, 2.2/12 bronchiectasis 6/12 thickening; im-κ, 0.04–0.3). Expiratory right/left collapse observed 51 47/583 on (62 57/599 CT; 0.49–0.52). Markers small airways 0.15/12 nodules (CT, 0.34/12), 0.94/12 0.9/12) 7.6/12 perfusion deficits 0.37/12 mosaic attenuation; 0.1–0.41). defect 1.3/12 emphysema score, 5.8/24; 0.18–0.26). Airway-/emphysema/mixed phenotypes assigned 370, 218 10 583 cases (347, 34 599 0.63). For all examined features, lower than Conclusion Concordance a setting substantial variable inter-modality single diagnostic key features. Clinical relevance statement morphology may well serve radiation-free imaging modality scientific clinical settings, given that its potential limitations shown here are carefully considered. Key Points • In setting, showed (airway-/emphysema-/mixed-type). Individual features demonstrated hypertension showing the highest lowest concordance. COPD,

Язык: Английский

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Supplemental Screening With MRI in Women With Dense Breasts: The European Perspective

Journal of Breast Imaging, Год журнала: 2025, Номер unknown

Опубликована: Янв. 21, 2025

Abstract Breast cancer is the most prevalent in women Europe, and while all European countries have some form of screening for breast cancer, disparities organization implementation exist. density a well-established risk factor cancer; however, Europe do not recommendations place notification or additional supplementary imaging with dense breasts. Various supplemental modalities been investigated when comparing modalities, MRI has shown to be superior detection rate detecting small invasive disease that may impact long-term survival, as demonstrated Dense Tissue Early Neoplasm Screening (DENSE) trial Netherlands. Based on convincing evidence, Society Imaging issued category D undergo from ages 50 70 years at least every 4 preferably 2 3 years. However, currently no routinely offer BI-RADS breasts imaging. The reasons lack are multifactorial. Concerns regarding increased recalls cited, cost resources. studies cost-effective compared current standard biannual mammography. Furthermore, abbreviated protocols could facilitate more widespread use affordable screening. Women’s perception key successful implementation.

Язык: Английский

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Diagnostic performance of abbreviated non-contrast MRI for liver metastases in patients with newly diagnosed breast cancer

Clinical Imaging, Год журнала: 2025, Номер unknown, С. 110461 - 110461

Опубликована: Март 1, 2025

Язык: Английский

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Molecular and supramolecular routes to enhance Gadolinium-Based Contrast Agents relaxivity: How far are we from the theoretical optimal value?

European Journal of Medicinal Chemistry, Год журнала: 2025, Номер 292, С. 117668 - 117668

Опубликована: Апрель 24, 2025

Язык: Английский

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Non-Contrast-Enhanced Multiparametric MRI of the Hypoxic Tumor Microenvironment Allows Molecular Subtyping of Breast Cancer: A Pilot Study

Cancers, Год журнала: 2024, Номер 16(2), С. 375 - 375

Опубликована: Янв. 16, 2024

Tumor neoangiogenesis is an important hallmark of cancer progression, triggered by alternating selective pressures from the hypoxic tumor microenvironment. Non-invasive, non-contrast-enhanced multiparametric MRI combining blood-oxygen-level-dependent (BOLD) MRI, which depicts blood oxygen saturation, and intravoxel-incoherent-motion (IVIM) captures intravascular extravascular diffusion, can provide insights into oxygenation neovascularization simultaneously. Our objective was to identify imaging markers that predict hypoxia-induced angiogenesis validate our findings using multiplexed immunohistochemical analyses. We present in vivo study involving 36 female athymic nude mice inoculated with luminal A, Her2+, triple-negative breast cells. used a high-field 9.4-tesla system for subsequently analyzed tumors multiplex immunohistochemistry CD-31, PDGFR-β, Hif1-α. found hyperoxic-BOLD-MRI-derived parameter ΔR2* discriminated A Her2+ cancers, while IVIM-derived fIVIM cancers. comprehensive analysis principal-component both MRI- mpIHC-derived data highlighted differences between conclude hyperoxic BOLD IVIM without need contrast agents, offers promising non-invasive evaluating angiogenesis.

Язык: Английский

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Long-term effects of linear versus macrocyclic GBCAs on gene expression in the central nervous system of mice

European Radiology Experimental, Год журнала: 2025, Номер 9(1)

Опубликована: Янв. 10, 2025

Abstract Background We examined chronic gadolinium retention impact on gene expression in the mouse central nervous system (CNS) after injection of linear or macrocyclic gadolinium-based contrast agents (GBCAs). Methods From 05/2022 to 07/2023, 36 female mice underwent weekly intraperitoneal injections gadodiamide (2.5 mmol/kg, linear), gadobutrol macrocyclic), saline. Mice were sacrificed day 29 391 a 1-year washout. Assessments included magnetic resonance imaging (MRI), mechanical hyperalgesia tests, and inductively coupled plasma mass spectrometry measure levels. Ribonucleic acid (RNA) sequencing bioinformatic analyses identified differentially expressed genes (DEGs), with validation by quantitative reverse transcription polymerase chain reaction (qRT-PCR) western blot (WB). Results Post-gadodiamide, MRI showed increased signal intensity deep cerebellar nuclei (pre, 0.997 ± 0.006 versus post, 1.086 0.013, p < 0.001). Mechanical tests indicated transient sensory changes. After 1-year, was noted brain (5.92 0.32 nmol/kg) spinal cord (1.23 0.66 gadodiamide, compared saline controls (0.06 0.02 nmol/kg brains 0.28 0.06 cords). RNA 17 shared DEGs between group 391, altered Hmgb2 Sgk1 confirmed qRT-PCR WB. Reactome pathway analysis enrichment neuroinflammation pathways. No detected 29. Conclusion Chronic deposition from repeated GBCA but not administration causes significant alterations CNS, particularly affecting Relevance statement This study long-term uncovering changes associated pathways GBCA, GBCA. These findings highlight importance further research safety medical imaging. Key Points alters system. Significant neuroinflammatory observed exposure. injection. Graphical

Язык: Английский

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Reliability of Central Vein Sign Imaging With 3T FLAIR* in a Multicenter Study

Journal of Neuroimaging, Год журнала: 2025, Номер 35(1)

Опубликована: Янв. 1, 2025

ABSTRACT Background and Purpose The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* combined MRI contrast that provides high conspicuity CVS at 3 Tesla (3T), enabling its sensitive accurate detection in clinical settings. This study evaluated whether of 3T reliable across sites vendors gadolinium (Gd) increases conspicuity. Methods A cross‐sectional, multicenter recruited adults referred possible diagnosis MS 10 sites. was generated using high‐resolution T2*‐weighted (acquired pre‐ post‐injection Gd) T2‐weighted fluid‐attenuated inversion recovery (T2‐FLAIR) brain images from two vendors. Lesions veins were segmented to compute lesion‐to‐vein contrast‐to‐noise ratio (CNR ), quantitative measure CNR measures post‐Gd compared Results Eighty‐seven participants nine included the analysis. There no significant difference mean between pre‐Gd ( p ‐value = 0.07) or 0.27) FLAIR*. also differences 0.10) 0.31) Patient‐level pairwise revealed increase < 0.001). Conclusions on consistent Moreover, Gd‐based agent significantly improved These findings support implementation settings MS.

Язык: Английский

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