Journal of Psychosomatic Research,
Год журнала:
2024,
Номер
189, С. 111999 - 111999
Опубликована: Ноя. 28, 2024
This
research
seeks
to
assess
the
connection
between
healthy
sleep
patterns
and
occurrence
of
kidney
stone
disease
(KSD)
by
analyzing
data
obtained
from
a
large-scale
cohort
study.
We
examined
313,870
initial
participants
without
KSD
UK
Biobank.
Five
factors
were
assessed:
no
frequent
excessive
daytime
sleepiness,
early
chronotype,
snoring,
sleeping
7-8
h
daily,
never
or
rarely
experiencing
insomnia
at
baseline.
A
score
0
5
was
assigned
according
these
criteria.
utilized
Cox
proportional
hazards
models
calculate
hazard
ratios
(HR)
95
%
confidence
intervals
(CI)
KSD.
During
follow-up
period,
3818
new
cases
recorded.
After
comprehensive
adjustments,
every
1-point
rise
in
associated
with
an
HR
0.93
(95
CI:
0.90-0.96).
Additionally,
individuals
had
20
lower
risk
compared
those
scores
2.
Our
study
results
indicate
that
adhering
pattern
can
reduce
Diseases,
Год журнала:
2025,
Номер
13(1), С. 7 - 7
Опубликована: Янв. 2, 2025
Urinary
stones
(urolithiasis)
have
been
categorized
as
kidney
(renal
calculus),
ureteric
(ureteral
calculus
and
ureterolith),
bladder
(bladder
urethral
(urethral
calculus);
however,
the
mechanisms
underlying
their
promotion
related
injuries
in
glomerular
tubular
cells
remain
unclear.
Although
lifestyle-related
diseases
(LSRDs)
such
hyperglycemia,
type
2
diabetic
mellitus,
non-alcoholic
fatty
liver
disease/non-alcoholic
steatohepatitis,
cardiovascular
disease
are
risk
factors
for
urolithiasis,
Recently,
heat
shock
protein
90
(HSP90)
on
membrane
of
HK-2
human
proximal
epithelium
has
associated
with
adhesion
urinary
cytotoxicity.
Further,
HSP90
pancreatic
breast
can
be
modified
by
various
advanced
glycation
end-products
(AGEs),
thus
affecting
function.
Hypothesis
1:
We
hypothesized
that
HSP90s
on/in
types
AGEs,
they
may
affect
functions
it
a
key
to
reveal
LSRDs
urolithiasis.
2:
considered
possibility
Japanese
traditional
medicines
urolithiasis
inhibit
AGE
generation.
Of
Choreito
Urocalun
(the
extract
Quercus
salicina
Blume/Quercus
stenophylla
Makino)
used
clinic,
is
Kampo
medicine,
while
characteristic
medicine.
As
contains
quercetin,
hesperidin,
p-hydroxy
cinnamic
acid,
which
generation,
we
generation
AGE-modified
cells.
Kidney & Blood Pressure Research,
Год журнала:
2025,
Номер
unknown, С. 1 - 25
Опубликована: Янв. 2, 2025
Introduction:
This
study
aimed
to
investigate
the
potential
association
between
fatty
liver
index
(FLI),
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
and
risk
of
kidney
stones
using
large-scale
population-based
data.
Methods:
employed
a
cross-sectional
design,
utilizing
data
from
2007-2018
National
Health
Nutrition
Examination
Survey
(NHANES)
database.
A
total
24,342
participants
were
enrolled
in
study,
status
was
assessed
by
calculating
FLI.
MASLD
diagnosed
FLI
conjunction
with
cardiometabolic
criteria.
Data
on
history
obtained
self-report.
We
logistic
regression
models
analyze
FLI,
MASLD,
stone
constructed
multivariable
adjustment
control
for
confounders.
Furthermore,
we
used
restricted
cubic
spline
curve
dose-response
relationship
conducted
subgroup
interaction
analyses.
Results:
The
study's
results
indicate
strong
correlation
increasing
quartiles
notable
rise
prevalence
stones.
Specifically,
developing
1.68
times
higher
among
highest
quartile
compared
those
lowest.
patients
exhibited
1.35-fold
increased
non-MASLD.
Subgroup
analyses
demonstrated
that
consistent
across
multiple
subgroups.
However,
significant
observed
subgroups
smoking
status,
physical
activity
level,
hypertension
(interaction
P
<
0.05).
analysis
did
not
yield
statistically
nonlinear
risk.
identify
inflection
point
values
Conclusion:
an
suggests
these
conditions
may
be
pivotal
factors
Further
investigation
is
required
elucidate
associations'
underlying
mechanisms
develop
efficacious
interventions
reduce
Also,
formulating
personalized
prevention
treatment
strategies
different
population
paramount.
Journal of Health Population and Nutrition,
Год журнала:
2025,
Номер
44(1)
Опубликована: Янв. 13, 2025
Evidence
concerning
the
effect
of
cardiovascular
health
(CVH)
on
risk
metabolic
dysfunctional-associated
steatotic
liver
disease
(MASLD)
is
scarce.
This
study
aimed
to
investigate
association
between
CVH
and
MASLD.
5680
adults
aged
≥
20
years
from
National
Health
Nutrition
Examination
Survey
2017-March
2020
were
included.
Life's
essential
8
(LE8)
was
applied
assess
CVH.
Weighted
binary
logistic
regression
employed
calculate
odds
ratio
(OR)
95%
confidence
interval
(CI)
with
Restricted
cubic
spline
(RCS)
conducted
explore
dose-response
LE8
its
subscales
scores
Among
participants,
724,
3901,
1055
had
low,
moderate,
high
levels,
respectively,
a
MASLD
diagnosis
prevalence
36.83%.
In
fully
adjusted
model,
ORs
for
0.50
(95%
CI,
0.37–0.69)
participants
moderate
0.21
0.13–0.34)
those
CVH,
when
compared
low
(P
<
0.001
trend).
OR
0.68
0.61–0.77)
each
10-point
increase
in
score.
RCS
model
demonstrated
non-linear
relationship
score
factors
MASLD,
while
linear
found
behaviors
Subgroup
analysis
showed
consistent
negative
correlation
sensitivity
validated
reliability
these
findings.
Higher
associated
lower
Encouraging
adherence
optimal
levels
may
help
mitigate
burden
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 21, 2025
This
study
investigates
the
relationship
between
Life's
Essential
8
(LE8)
scores
and
bone
mineral
density
(BMD)
in
adults
aged
20–59
years.
cross-sectional
analysis
employed
nationally
representative
data
from
NHANES
2011–2018.
Weighted
multiple
linear
regression
models
were
applied
to
assess
association
LE8
varying
levels
of
cardiovascular
health
(CVH)
with
BMD.
Subgroup
analyses
performed
evaluate
differences
impact
on
BMD
across
age
groups,
genders,
races,
socioeconomic
statuses,
BMI
categories.
The
included
2159
participants.
After
adjusting
for
all
covariates,
demonstrated
a
significant
positive
lumbar
spine
BMD,
thoracic
trunk
total
Individuals
medium
high
CVH
groups
exhibited
higher
compared
those
low
group.
indicated
that
was
more
evident
participants
20–35
years
among
normal
BMI.
In
females,
appeared
particularly
sensitive
changes
scores.
identifies
Higher
linked
greater
These
findings
highlight
importance
adopting
comprehensive
strategies,
suggesting
improving
may
contribute
maintaining
supporting
skeletal
health.
Frontiers in Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Фев. 10, 2025
Background
Asthma
is
a
serious
respiratory
disease
attributed
to
multiple
factors.
The
Life’s
Essential
8
(LE8),
introduced
by
the
American
Heart
Association,
aims
improve
and
maintain
cardiovascular
health.
However,
correlation
between
LE8
components
asthma
remains
unclear.
We
hypothesized
that
protective
factor
against
asthma.
Materials
methods
Multiple
logistic
regression
analysis,
restricted
cubic
spline
(RCS)
subgroup
analysis
were
used
analyze
data
collected
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2001
2018.
Results
A
total
of
3,360
participants
with
included
in
analysis.
With
all
confounders
controlled
for,
scores
negatively
correlated
prevalence
(odds
ratio
(OR)
per
10-point
increment,
0.85
[95%
confidence
interval
(CI),
0.82–0.88]).
Compared
low
scores,
moderate
high
associated
reduced
risk,
adjusted
ORs
(95%
CIs)
0.59
(0.51–0.68)
0.48
(0.39–0.58),
respectively.
Non-linear
correlations
observed
(
p
non-linear
=
0.01)
health
0.01).
linear
dose–response
was
noted
behavior
0.30).
Subgroup
showed
no
significant
interaction
effects
>
0.05),
except
sex
drinking
status
subgroups
for
0.02).
Conclusion
LE8,
which
warrants
further
attention
may
contribute
reducing
prevalence.
Objectives
To
investigate
the
correlation
between
Life’s
Essential
8
(LE8)
and
frailty
in
adults
with
asthma
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES).
Methods
We
conducted
a
cross-sectional
study
by
NHANES
(2001-2018)
to
assess
relationship
LE8
patients.
Multiple
logistic
regression,
restricted
cubic
spline
(RCS)
analysis,
subgroup
analyses
were
performed
evaluate
potential
associations.
Results
Among
3,
238
of
91
351
participants,
1066
patients
demonstrated
2172
not.
When
comparing
groups
moderate
high
scores
group
low
scores,
odds
ratios
(ORs)
(95%
confidence
intervals)
for
0.39
(0.27,
0.56)
0.15
(0.08,
0.27),respectively.
Every
10-point
increment
was
negatively
correlated
asthma.
Similar
trends
observed
health
behavior
factor
scores.
ORs
0.54
(0.41,
0.72)
0.41(0.27,
0.64)
when
0.68
(0.48,
0.98)
0.50
(0.28,
0.88)
0.78
(0.72,
0.84)
both
every
Conclusions
Higher
along
linearly
inversely
associated
prevalence
asthma,
suggesting
that
improved
may
reduce
risk
population.
