SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis

Inflammation Research, Год журнала: 2025, Номер 74(1)

Опубликована: Фев. 10, 2025

Язык: Английский

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Morinda officinalis oligosaccharides alleviate chronic unpredictable mild stress-induced depression through the BDNF/TrkB/CREB pathway and symptoms of sexual dysfunction in mice

Frontiers in Neuroscience, Год журнала: 2025, Номер 18

Опубликована: Янв. 8, 2025

In recent years, depression has become a global public health concern, and one of the common concomitant symptoms are diminished sexual motivation impaired performance. The aim this study was to investigate potential effects Morinda officinalis oligosaccharides (MOO) on its symptom, dysfunction. Chronic unpredictable mild stress (CUMS)-induced model constructed, MOO abilities were evaluated. results revealed that able alleviate CUMS-induced depression-like behavior in mice, inhibit hippocampal neuron apoptosis, reverse monoamine neurotransmitter imbalance, increase Brain-derived neurotrophic factor (BDNF) expression levels hippocampus, modulate composition distribution gut microbiota, abundance probiotics after continuous gavage for 28 days. further confirmed dysfunction is closely related development by improving lack low performance depressed modulating disruption sex hormone secretion serum, alleviating sperm morphology functional defects epididymis. These findings provide basis exploring antidepressant mechanism, use improve hypogonadotropic symptoms, future new drug improves symptoms.

Язык: Английский

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Ferroptosis-associated signaling pathways and therapeutic approaches in depression

Frontiers in Neuroscience, Год журнала: 2025, Номер 19

Опубликована: Март 19, 2025

Ferroptosis, a newly identified form of cell death, is characterized by excessive iron accumulation and lipid peroxidation. Studies indicate strong association between ferroptosis depression; however, the precise signaling pathways underlying molecular mechanisms remain unclear. This review summarizes role in depression its associated pathways. Additionally, therapeutic approaches for based on theory are reviewed, providing novel targets prevention treatment laying foundation future research relationship depression.

Язык: Английский

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Natural products targeting ferroptosis in depression: Research progress and therapeutic prospects

Phytomedicine, Год журнала: 2025, Номер 142, С. 156818 - 156818

Опубликована: Апрель 28, 2025

Язык: Английский

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Pharmacological mechanisms of natural products with antidepressant effects: A focus on the programmed cell death regulation

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101356 - 101356

Опубликована: Июнь 1, 2025

Язык: Английский

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The SIRT6 allosteric activator MDL-800 suppresses calcium oxalate nephrocalcinosis by alleviating inflammatory and renal damage

International Immunopharmacology, Год журнала: 2024, Номер 146, С. 113864 - 113864

Опубликована: Дек. 19, 2024

Язык: Английский

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SIRT6 Mitigates Oxidative Stress and RSL3-Induced Ferroptosis in HTR-8/SVneo Cells

Tissue and Cell, Год журнала: 2024, Номер 93, С. 102639 - 102639

Опубликована: Ноя. 30, 2024

Язык: Английский

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