Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice DOI Creative Commons
Nabil V. Sayour, Dániel Kucsera,

Abdulaziz AlHaddad

и другие.

Basic Research in Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities manifestation severity immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. To elucidate whether affect ICI-induced cardiotoxicity, we randomized 17-month-old male female mice to receive control diet (CON) or high-fat (HFD) + L-NAME-a well-established mouse model co-morbidities-for 17 weeks (n = 5-7), evaluated markers T-cell function in spleen. As expected, HFD L-NAME significantly increased body- heart weight, serum cholesterol levels, caused no systolic dysfunction, however, led diastolic cardiomyocyte hypertrophy, fibrosis only males compared corresponding CON. Western blot analyses splenic protein levels showed differential expression depending co-morbidities, suggesting exhaustion both sexes L-NAME, but more pronounced males. In a sub-study with similar setup, tested cardiotoxic manifestations ICI by treating anti-PD-1 monoclonal antibody (ICI) for last 2 administration 5-7). After treatment, cardiac functions decreased CON, groups baseline (before administration). conclusion, this exploratory study using aged mice, describe first time that ICI-related dysfunction is diminished when obesity hypercholesterolemia are present, possibly due obesity-related exhaustion.

Язык: Английский

Autophagy in Heart Failure: Insights into Mechanisms and Therapeutic Implications DOI Creative Commons

Magdalena Bielawska,

Marta Warszyńska, Monika Stefańska

и другие.

Journal of Cardiovascular Development and Disease, Год журнала: 2023, Номер 10(8), С. 352 - 352

Опубликована: Авг. 18, 2023

Autophagy, a dynamic and complex process responsible for the clearance of damaged cellular components, plays crucial role in maintaining myocardial homeostasis. In context heart failure, autophagy has been recognized as response mechanism aimed at counteracting pathogenic processes promoting health. Its relevance underscored not only various animal models, but also human heart. Extensive research efforts have dedicated to understanding significance unravelling its molecular mechanisms. This review aims consolidate current knowledge involvement during progression failure. Specifically, we provide comprehensive overview published data on impact deregulation achieved by genetic modifications or pharmacological interventions ischemic non-ischemic models Furthermore, delve into intricate mechanisms through which regulates within three predominant cell populations heart: cardiomyocytes, cardiac fibroblasts, endothelial cells. Finally, emphasize need future unravel therapeutic potential associated with targeting management

Язык: Английский

Процитировано

9

Vasodilator reactive oxygen species ameliorate perturbed myocardial oxygen delivery in exercising swine with multiple comorbidities DOI Creative Commons
R W A Van Drie, Jens van de Wouw, Lotte Zandbergen

и другие.

Basic Research in Cardiology, Год журнала: 2024, Номер 119(5), С. 869 - 887

Опубликована: Май 25, 2024

Multiple common cardiovascular comorbidities produce coronary microvascular dysfunction. We previously observed in swine that a combination of diabetes mellitus (DM), high fat diet (HFD) and chronic kidney disease (CKD) induced systemic inflammation, increased oxidative stress produced endothelial dysfunction, altering control tone via loss NO bioavailability, which was associated with an increase circulating endothelin (ET). In the present study, we tested hypotheses (1) ROS scavenging (2) ET

Язык: Английский

Процитировано

3

Low protein adsorption and high cellular activity of PEG-based silicone polyurethane for artificial heart valves DOI

Sailong Wei,

Jiangjie Wu,

Xiaokai Gu

и другие.

Materials Today Communications, Год журнала: 2024, Номер 39, С. 109357 - 109357

Опубликована: Май 26, 2024

Язык: Английский

Процитировано

3

Investigating the cause of cardiovascular dysfunction in chronic kidney disease: capillary rarefaction and inflammation may contribute to detrimental cardiovascular outcomes DOI Creative Commons
Siavash Beikoghli Kalkhoran, Marina Basalay, Zhenhe He

и другие.

Basic Research in Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Окт. 30, 2024

Язык: Английский

Процитировано

3

Effects of sex and obesity on immune checkpoint inhibition-related cardiac systolic dysfunction in aged mice DOI Creative Commons
Nabil V. Sayour, Dániel Kucsera,

Abdulaziz AlHaddad

и другие.

Basic Research in Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 8, 2024

Despite accumulating data on underlying mechanisms, the influence of sex and prevalent cardio-metabolic co-morbidities manifestation severity immune checkpoint inhibitor (ICI)-induced cardiotoxicity has not been well defined. To elucidate whether affect ICI-induced cardiotoxicity, we randomized 17-month-old male female mice to receive control diet (CON) or high-fat (HFD) + L-NAME-a well-established mouse model co-morbidities-for 17 weeks (n = 5-7), evaluated markers T-cell function in spleen. As expected, HFD L-NAME significantly increased body- heart weight, serum cholesterol levels, caused no systolic dysfunction, however, led diastolic cardiomyocyte hypertrophy, fibrosis only males compared corresponding CON. Western blot analyses splenic protein levels showed differential expression depending co-morbidities, suggesting exhaustion both sexes L-NAME, but more pronounced males. In a sub-study with similar setup, tested cardiotoxic manifestations ICI by treating anti-PD-1 monoclonal antibody (ICI) for last 2 administration 5-7). After treatment, cardiac functions decreased CON, groups baseline (before administration). conclusion, this exploratory study using aged mice, describe first time that ICI-related dysfunction is diminished when obesity hypercholesterolemia are present, possibly due obesity-related exhaustion.

Язык: Английский

Процитировано

3