Effect of endothelial responses on sepsis-associated organ dysfunction DOI Creative Commons
Miao Wu, Yan Yan, Xinyu Xie

и другие.

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Sepsis-related organ dysfunction is associated with increased morbidity and mortality. Previous studies have found that the endothelium plays crucial roles in maintaining vascular permeability during sepsis, as well regulating inflammation thrombosis. During endothelial cells may release cytokines, chemokines, pro-coagulant factors, express adhesion molecules. In general, responses sepsis typically inhibit bacterial transmission coordinate leukocyte recruitment to promote clearance. However, excessive or prolonged activation can lead impaired microcirculation, tissue hypoperfusion, dysfunction. Given structural functional heterogeneity of different organs, there are potential differences by type, risk damage vary accordingly. This article reviews response observed its effects on function, summarizes current progress development therapeutic interventions targeting response, discusses future research directions serve a reference for researchers field.

Язык: Английский

Effect of endothelial responses on sepsis-associated organ dysfunction DOI Creative Commons
Miao Wu, Yan Yan, Xinyu Xie

и другие.

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 6, 2024

Abstract Sepsis-related organ dysfunction is associated with increased morbidity and mortality. Previous studies have found that the endothelium plays crucial roles in maintaining vascular permeability during sepsis, as well regulating inflammation thrombosis. During endothelial cells may release cytokines, chemokines, pro-coagulant factors, express adhesion molecules. In general, responses sepsis typically inhibit bacterial transmission coordinate leukocyte recruitment to promote clearance. However, excessive or prolonged activation can lead impaired microcirculation, tissue hypoperfusion, dysfunction. Given structural functional heterogeneity of different organs, there are potential differences by type, risk damage vary accordingly. This article reviews response observed its effects on function, summarizes current progress development therapeutic interventions targeting response, discusses future research directions serve a reference for researchers field.

Язык: Английский

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