Dissecting the association between breast cancer and scar conditions and fibrosis of skin : a bidirectional Mendelian randomization study
Abstract
Background
Scar
hyperplasia
and
skin
fibrosis
following
breast
cancer
operation
has
long
been
recognized
as
one
of
the
major
effects
affecting
patients'
quality
life.
However,
there
is
currently
a
lack
direct
evidence
examining
impact
on
scar
conditions
skin.
Methods
In
this
study,
two-way,
two-sample
Mendelian
randomisation
(MR)
approach
utilising
pooled
data
from
genome-wide
association
study
(GWAS)
we
employed
to
investigate
potential
causal
relationship
between
(BC)
skin.In
forward
MR,
it
was
postulated
that
BC
exposure
factor,
whereas
in
reverse
were
posited
factors.
To
enhance
reliability
results,
two
databases
(finna-a-L12_SCARCONDITIONS;
ukb-b-11403
)
examine
these
factors.In
order
explore
skin,
various
analytical
techniques
utilised,
including
random
inverse
variance
weighted
(IVW)
MR-Egger
analyses.Furthermore,
sensitivity
analyses
assessments
heterogeneity
multiplicity
conducted
results.
Results
The
MR
analysis
indicates
associated
with
an
elevated
risk
skin(OR
=
1.310,
95%CI
1.052–1.630,
p
0.015
and(OR
1.00047,
1.000016–1.000928,
p
0.042
.In
contrast,
did
not
identify
factor
influencing
risk.Furthermore,
results
demonstrated
absence
for
or
pleiotropy.
Conclusion
This
showed
positive
exists
European
populations.
also
offers
novel
perspective
mechanism
postoperative
formation
patients,
provides
basis
clinical
assessment
prognosis
based
status
surgical
scarring
degree
dermal
fibrosis.
Research Square (Research Square), Год журнала: 2024, Номер unknown
Опубликована: Окт. 8, 2024
Язык: Английский