Disrupted Redox Regulation and Inflammatory Response in Pyoderma Gangrenosum DOI Creative Commons
Simona Roxana Georgescu, Clara Matei, Corina Daniela Ene

и другие.

Life, Год журнала: 2025, Номер 15(4), С. 611 - 611

Опубликована: Апрель 6, 2025

Introduction. The pathophysiology of Pyoderma Gangrenosum (PG) involves altered innate and adaptive immunity, mutagenic epigenetic changes, the autoinflammatory state, overexpression cytokines. This study investigated potential contribution inflammation, redox signaling, immune system in pathogenesis PG. Materials Methods. case–control included 36 patients with PG 30 controls. We have determined serum concentrations acute phase proteins (C-reactive protein—CRP, alpha1 glycoprotein acid—AGPA, Albumin), interleukin-17A -IL-17A, β2 microglobulin-β2MG, reduced glutathione-GSH, oxidized glutathione- GSSG, GSH/GSSG ratio, hematological parameters (white blood cells-WBC, neutrophil-lymphocyte ratio-NLR, erythrocyte sedimentation rate-ESR) compared Furthermore, we evaluated variations these markers before after treatment patients. Results. (CRP, AGPA, Albumin) IL-17A, β2MG, GSH, ratio were significantly different between group Hematological (WBC, NLR, ESR), albumin), IL-17A showed an exaggerated persistent inflammatory response In associated systemic diseases, dysregulation biochemical events was more severe. Conclusions. proteins, β2MG-MHC class I complex, GSH-GSSG are unbalanced Our results could improve diagnosis our understanding pathogenic basis

Язык: Английский

Disrupted Redox Regulation and Inflammatory Response in Pyoderma Gangrenosum DOI Creative Commons
Simona Roxana Georgescu, Clara Matei, Corina Daniela Ene

и другие.

Life, Год журнала: 2025, Номер 15(4), С. 611 - 611

Опубликована: Апрель 6, 2025

Introduction. The pathophysiology of Pyoderma Gangrenosum (PG) involves altered innate and adaptive immunity, mutagenic epigenetic changes, the autoinflammatory state, overexpression cytokines. This study investigated potential contribution inflammation, redox signaling, immune system in pathogenesis PG. Materials Methods. case–control included 36 patients with PG 30 controls. We have determined serum concentrations acute phase proteins (C-reactive protein—CRP, alpha1 glycoprotein acid—AGPA, Albumin), interleukin-17A -IL-17A, β2 microglobulin-β2MG, reduced glutathione-GSH, oxidized glutathione- GSSG, GSH/GSSG ratio, hematological parameters (white blood cells-WBC, neutrophil-lymphocyte ratio-NLR, erythrocyte sedimentation rate-ESR) compared Furthermore, we evaluated variations these markers before after treatment patients. Results. (CRP, AGPA, Albumin) IL-17A, β2MG, GSH, ratio were significantly different between group Hematological (WBC, NLR, ESR), albumin), IL-17A showed an exaggerated persistent inflammatory response In associated systemic diseases, dysregulation biochemical events was more severe. Conclusions. proteins, β2MG-MHC class I complex, GSH-GSSG are unbalanced Our results could improve diagnosis our understanding pathogenic basis

Язык: Английский

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