Cell Stress,
Год журнала:
2024,
Номер
11, С. 59 - 68
Опубликована: Май 27, 2024
For
many
diseases,
and
cancer
in
particular,
early
diagnosis
allows
a
wider
range
of
therapies
better
disease
management.
This
has
led
to
improvements
diagnostic
procedures,
most
often
based
on
tissue
biopsies
or
blood
samples.
Other
biological
fluids
have
been
used
diagnose
disease,
among
them
saliva
offers
number
advantages
because
it
can
be
collected
non-invasively
from
large
populations
at
relatively
low
cost.
To
what
extent
might
content
reveal
the
presence
tumour
located
distance
oral
cavity
molecular
information
obtained
establish
are
current
questions.
review
focuses
primarily
shows
how
potentially
source
diagnosis,
possibly
an
stage,
for
pathologies
such
as
cancers
endometriosis.
Upsala Journal of Medical Sciences,
Год журнала:
2024,
Номер
129, С. e10614 - e10614
Опубликована: Март 27, 2024
Deeper
analysis
of
molecular
mechanisms
arising
in
tumor
cells
is
an
unmet
need
to
provide
new
diagnostic
and
therapeutic
strategies
prevent
treat
tumors.
The
transforming
growth
factor
β
(TGF-β)
signaling
has
been
steadily
featured
biology
linked
poor
prognosis
cancer
patients.
One
pro-tumorigenic
mechanism
induced
by
TGF-β
the
epithelial-to-mesenchymal
transition
(EMT),
which
can
initiate
dissemination,
enrich
stem
cell
population,
increase
chemoresistance.
signals
via
SMAD
proteins,
ubiquitin
ligases,
protein
kinases
modulates
expression
protein-coding
non-coding
RNA
genes,
including
those
encoding
larger
than
500
nt
transcripts,
defined
as
long
RNAs
(lncRNAs).
Several
reports
have
shown
lncRNAs
regulating
malignant
phenotypes
directly
affecting
epigenetic
processes,
transcription,
post-transcriptional
regulation.
Thus,
this
review
aims
update
summarize
impact
on
function
such
regulators
signaling,
how
these
networks
might
specific
hallmarks
cancer.
Human Molecular Genetics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 7, 2025
Abstract
This
study
systematically
explores
the
oncogenic
role
of
long
non-coding
RNA
(lncRNA)
LINC00115
in
endometrial
cancer
(EC)
and
reveals
its
unique
mechanism
promoting
proliferation,
invasion,
metastasis
via
JAK/STAT
signaling
pathway.
is
significantly
upregulated
EC
tissues
closely
associated
with
advanced
TNM
staging
lymph
node
metastasis.
Functional
assays
showed
that
knockdown
suppressed
cell
metastasis,
while
overexpression
enhanced
these
malignant
behaviors.
In
vivo
models
confirmed
accelerates
tumor
growth
Our
first
to
identify
as
a
key
activator
pathway
through
direct
interaction
KH-type
Splicing
Regulatory
Protein
(KHSRP),
previously
unrecognized
EC.
finding
provides
new
insights
into
lncRNA-mediated
regulation
highlights
novel
biomarker
promising
therapeutic
target
for
EC,
offering
theoretical
basis
developing
targeted
therapies.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Янв. 27, 2025
Background
Disulfidptosis
and
ferroptosis
are
two
different
programmed
cell
death
pathways,
their
potential
therapeutic
targets
have
important
clinical
prospects.
Although
there
is
an
association
between
the
two,
role
of
genes
associated
with
these
forms
in
development
endometrial
cancer
remains
unclear.
Methods
In
this
study,
RNA
sequencing
(RNA-seq)
data
were
obtained
from
public
databases,
comprehensive
analysis
methods,
including
difference
analysis,
univariate
Cox
regression,
Least
Absolute
Shrinkage
Selection
Operator
(LASSO)
used
to
construct
a
disulfidptosis/ferroptosis-related
(DFRGs)
prognostic
signature.
To
further
explore
new
feature,
pathway
functional
analyses
performed,
differences
gene
mutation
frequency
level
immune
infiltration
high-
low-risk
groups
studied.
Finally,
we
validated
expression
profile
samples.
Results
We
identified
five
optimal
DFRGs
that
differentially
expressed
prognosis
uterine
corpus
carcinoma
(UCEC).
These
include
CDKN2A,
FZD7,
LCN2,
ACTN4,
MYH10.
Based
on
DFRGs,
constructed
robust
model
significantly
lower
overall
survival
high-risk
group
than
group,
tumor
burden
invasion
risk
groups.
The
key
genes,
ACTN4
was
verified
by
immunohistochemistry
RT-qPCR.
Conclusion
This
study
established
characteristics
assessment
disulfidptosis
provides
insights
guide
patient
management
personalized
treatment.
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0314314 - e0314314
Опубликована: Янв. 30, 2025
Endometrial
cancer
(UCEC)
is
the
most
prevalent
gynecological
malignancy
in
high-income
countries,
and
its
incidence
rising
globally.
Although
early-stage
UCEC
can
be
treated
with
surgery,
advanced
cases
have
a
poor
prognosis,
highlighting
need
for
effective
molecular
biomarkers
to
improve
diagnosis
prognosis.
In
this
study,
we
analyzed
mRNA
miRNA
sequencing
data
from
tissues
adjacent
non-cancerous
TCGA
database.
Differential
expression
analysis
was
conducted
using
DESeq2
package,
identifying
differentially
expressed
lncRNAs,
miRNAs,
mRNAs
(DElncRNAs,
DEmiRNAs,
DEmRNAs).
Key
molecules
were
screened
LASSO
regression,
ceRNA
network
constructed
by
predicting
lncRNA-miRNA
miRNA-mRNA
interaction,
which
visualized
Cytoscape.
Functional
enrichment
elucidated
roles
mechanisms
of
network.
The
prognostic
potential
identified
RNAs
assessed
through
survival
Cox
regression
analyses,
while
methylation
immune
infiltration
analyses
explored
regulatory
interactions.
We
lncRNA-miRNA-mRNA
UCEC,
centered
on
CDKN2B-AS1-hsa-miR-497-5p-IGF2BP3
axis.
Survival
confirmed
significance
network,
univariate
demonstrating
strong
association
between
aberrant
overall
prognosis
UCEC.
However,
multivariate
suggested
that
other
clinical
factors
may
modulate
relationship.
Methylation
revealed
low
levels
IGF2BP3,
possibly
contributing
overexpression.
Furthermore,
studies
highlighted
significant
correlations
CDKN2B-AS1,
multiple
cell
types,
suggesting
axis
regulates
tumor
microenvironment.
These
findings
suggest
key
element
therapeutic
target.
Clinical and Experimental Medicine,
Год журнала:
2025,
Номер
25(1)
Опубликована: Фев. 11, 2025
Overcoming
cancer
and
enhancing
patient
survival
are
becoming
increasingly
challenging
due
to
the
uncontrolled
growth
metastasis
of
colorectal
cells.
In
order
provide
effective
treatment
minimize
malignancy
cells,
it
is
necessary
understand
how
complex
signaling
networks
contribute
their
invasion
proliferation.
The
signal
transducer
activator
transcription
3
(STAT3)
a
promising
target
its
involvement
in
various
cellular
functions,
including
apoptosis,
immunosuppression,
cell
invasion,
migration,
Dysregulation
STAT3
associated
with
diseases,
particularly
cancer.
Long
non-coding
RNAs
(lncRNAs),
subset
RNAs,
essential
for
progression,
CRC
as
they
regulate
key
pathways
such
gene
regulation
at
epigenetic,
transcriptional,
post-transcriptional
levels.
Moreover,
lncRNAs
have
function
regulating
immune
cells
through
STAT3.
this
study,
we
comprehensively
reviewed
regulatory
roles
different
on
mutual
effects
pathway
aspects
carcinogenesis,
proliferation,
metastasis,
drug
resistance,
angiogenesis.
investigate
lncRNA/STAT3
axis
that
play
critical
role
tumor
microenvironment.
AbstractBackground
Long
non-coding
RNAs
(lncRNAs)
are
crucial
regulators
of
ovarian
cancer(OC),
playing
a
significant
role
in
malignant
transformation
and
closely
linked
to
poor
prognosis.
Therefore,
it
is
investigate
the
impact
lncRNAs
on
biological
behavior
cancer
understand
their
underlying
molecular
mechanisms.
Methods
The
binding
sites
target
genes
were
predicted
through
bioinformatics
analysis,
gene
expression
levels
measured
using
qRT-PCR.
cells
was
assessed
cell
function
assays.
Gene
targeting
relationships
verified
dual-luciferase
reporter
gene(DLRG)
assay.
Protein
analyzed
Western
blotting.
Results
Hyaluronan-mediated
motility
receptor
antisense
RNA1(HMMR-AS1)
upregulated
cells.
Cell
experiments
demonstrated
that
HMMR-AS1
promotes
behaviors
DLRG
targets
miR-627-3p,
which
turn
pleiotrophin(PTN).
Furthermore,
we
discovered
functions
as
competing
endogenous
RNA
(ceRNA)
for
regulating
PTN
thereby
promoting
phenotypes
Conclusions
In
summary,
our
study
indicates
lncRNA
highly
expressed
plays
carcinogenic
role.
Targeting
may
offer
novel
therapeutic
strategy
treating
cancer.
