Chronic post-COVID neuropsychiatric symptoms persisting beyond one year from infection: a case-control study and network analysis DOI Creative Commons
Steven Wai Ho Chau, Timothy Mitchell Chue, Ngan Yin Chan

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2023, Номер unknown

Опубликована: Окт. 23, 2023

Abstract Background Limited data about chronic post-COVID neuropsychiatric complaints exist in the literature. Aim Our study aims to delineate phenotypes of symptoms among adult subjects recovering from their first COVID that occurred more than one year ago. We also aim explore clinical and socioeconomic risk factors having a high loading symptoms. Methods recruited group who suffered pre-Omicron ago, control had never COVID. The completed app-based questionnaires on demographic, health status, checklist, mental sleep measures, neurocognitive tests. Results has statistically significantly higher level fatigue compared (p<0.001). Among group, lack any vaccination before material deprivation pandemic predicts load Partial correlation network analysis suggests can be clustered into two major (cognitive -fatigue anxiety-depression) minor (headache-dizziness) cluster. A number both clusters, but only cognitive complaints-fatigue Conclusions result heterogeneity symptoms, which are associated with complex interplay biological factors.

Язык: Английский

The global prevalence of depression, anxiety, and sleep disorder among patients coping with Post COVID-19 syndrome (long COVID): a systematic review and meta-analysis DOI Creative Commons
Niloofar Seighali, Abolfazl Abdollahi, Arman Shafiee

и другие.

BMC Psychiatry, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 6, 2024

Post COVID-19 syndrome, also known as "Long COVID," is a complex and multifaceted condition that affects individuals who have recovered from SARS-CoV-2 infection. This systematic review meta-analysis aim to comprehensively assess the global prevalence of depression, anxiety, sleep disorder in coping with syndrome.

Язык: Английский

Процитировано

50
Incidence and burden of long COVID in Africa: a systematic review and meta-analysis DOI Creative Commons
Luisa Frallonardo, Francesco Vladimiro Segala,

Kajal Chhaganlal

и другие.

Scientific Reports, Год журнала: 2023, Номер 13(1)

Опубликована: Дек. 6, 2023

Abstract Long COVID, also known as “post-acute sequelae of COVID-19,” affects at least 65 million individuals worldwide with a wide spectrum symptoms that may last weeks, months, or permanently. Its epidemiology and burden in Africa are unclear. This meta-analysis examines long-term COVID-19 effects the WHO African Region. A systematic search several databases was carried out up to 12 February 2023 including observational studies from countries reporting cumulative incidence long COVID signs symptoms. Only conducted were included. Several sensitivity meta-regression analyses performed. Among 1547 papers initially screened, 25 included, consisting 29,213 participants. The any symptomatology 48.6% (95% CI 37.4–59.8) psychiatric conditions most frequent, particularly post-traumatic stress disorder reaching 25% 21.1–30.4). Higher age ( p = 0.027) hospitalization 0.05) associated higher frequency COVID. poses significant Africa, concerning conditions. study recommends identifying at-risk people defining treatment strategies recommendations for long-COVID patients. High-quality addressing this condition setting urgently needed.

Язык: Английский

Процитировано

21
SARS‐CoV‐2 induces blood‐brain barrier and choroid plexus barrier impairments and vascular inflammation in mice DOI

Haowen Qiao,

Xiangxue Deng,

Lingxi Qiu

и другие.

Journal of Medical Virology, Год журнала: 2024, Номер 96(5)

Опубликована: Май 1, 2024

Abstract The coronavirus disease of 2019 (COVID‐19) pandemic has led to more than 700 million confirmed cases and nearly 7 deaths. Although severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) virus mainly infects the system, neurological complications are widely reported in both infection long‐COVID cases. Despite success vaccines antiviral treatments, neuroinvasiveness SARS‐CoV‐2 remains an important question, which is also centered on mystery whether capable breaching barriers into central nervous system. By studying K18‐hACE2 model, we observed clear evidence microvascular damage breakdown blood‐brain barrier (BBB). Mechanistically, caused pericyte damage, tight junction loss, endothelial activation vascular inflammation, together drive injury BBB impairment. In addition, blood‐cerebrospinal fluid at choroid plexus was impaired after infection. Therefore, cerebrovascular dysfunctions aspects COVID‐19 may contribute acutely long COVID.

Язык: Английский

Процитировано

7
Cognitive function and quantitative electroencephalogram analysis in subjects recovered from COVID-19 infection DOI Creative Commons

Manal M. Gaber,

Hanan Hosny,

Mona Hussein

и другие.

BMC Neurology, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 10, 2024

Abstract Background & Objectives Objective assessment of post-COVID-19 cognitive dysfunction is highly warranted. This study aimed to evaluate the COVID-19 survivors with complaints, both clinically and neurophysiologically, using Quantitative Electroencephalogram (QEEG). Methods case–control was conducted on 50 recovered subjects from infection complaints age, sex, educational-matched healthy controls. Both groups were subjected following neurocognitive tests: Paired associate learning Test (PALT) Paced Auditory Serial Addition (PASAT). The neurophysiological also done for QEEG. Results had significantly lower PALT scores than controls ( P < 0.001). QEEG analysis found higher levels Theta / Beta ratio in central parietal areas patients 0.001 each). interhemispheric coherence frontal, central, regions control group regarding alpha beta bands. There statistically significant PASAT among cases severe = 0.011, 0.005 , respectively) those who needed oxygen support 0.04, 0.01, respectively). On other hand, a mean frontal inter-hemispheric 0.01) needing mechanical ventilation 0.04). Conclusion Episodic memory deficit evident subjective accompanied by regions. These clinical changes are associated hypoxia severity.

Язык: Английский

Процитировано

5
Post-COVID-19 conditions and health effects in Africa: a scoping review DOI Creative Commons
Edward Wilson Ansah, Promise Kwame Salu,

Martin Sumani Daanko

и другие.

BMJ Open, Год журнала: 2025, Номер 15(1), С. e088983 - e088983

Опубликована: Янв. 1, 2025

Introduction The SARS-CoV-2 pandemic has caused global devastations in social, economic and health systems of every nation, but disproportionately nations Africa. In addition to its grave effects on the systems, there is continuation or development new symptoms among individuals who have contracted virus, with potential further stress continent. Therefore, aim this scoping review was collate summarise existing research evidence prevalence post–COVID-19 conditions Methods analysis Five main databases were thoroughly searched from 1 September 2023 10 May 2024 for eligible articles based pre-established inclusion exclusion criteria. These included PubMed, Central, Scopus, Dimensions AI JSTOR. A total 17 papers review. protocol already published BMJ Open; doi:10.1136/bmjopen-2023-082519. Results Africa ranged 2% as high 94.7%. Fatigue, dyspnoea brain fog commonly reported conditions. Reduced functional status well physical psychosocial disorders by studies reviewed, no study yet Conclusions There an African setting. However, limited patients Ethics dissemination This involved secondary data; therefore, ethical approval needed. Dissemination result being done through international journals may also be presented at available conferences.

Язык: Английский

Процитировано

0
Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review DOI Creative Commons
Abby E. Rudolph,

Nadine Al Akoury,

Natalija Bogdanenko

и другие.

Human Vaccines & Immunotherapeutics, Год журнала: 2025, Номер 21(1)

Опубликована: Март 13, 2025

This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for relationship between COVID-19 vaccination Post-COVID-19 Condition (PCC) by timing relative to infection or PCC-onset. Comparisons vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) study characteristics known impact burden VE other endpoints were possible 31 studies where preceded infection. Seventy-seven percent pre-infection aVE statistically significant (range: 7%–95%). Statistically slightly higher mRNA 14%–84%) than non-mRNA vaccines 16%–38%) ranges before during Omicron overlapped. Our findings suggest SARS-CoV-2 reduces risk regardless type, number doses received, definition, predominant variant, severity acute infections included.

Язык: Английский

Процитировано

0
The Silent Syndrome of Long COVID and Gaps in Scientific Knowledge: A Narrative Review DOI Creative Commons
Rosilene da Silva, Antônio Carlos Rosário Vallinoto, Eduardo José Melo dos Santos

и другие.

Viruses, Год журнала: 2024, Номер 16(8), С. 1256 - 1256

Опубликована: Авг. 5, 2024

COVID-19 is still a major public health concern, mainly due to the persistence of symptoms or appearance new symptoms. To date, more than 200 long COVID (LC) have been described. The present review describes and maps its relevant clinical characteristics, pathophysiology, epidemiology, genetic nongenetic risk factors. Given currently available evidence on LC, we demonstrate that there are gaps controversies in diagnosis, detection prognostic predictive factors, as well role viral strain vaccination.

Язык: Английский

Процитировано

3
Course of fatigue among patients previously hospitalised due to COVID-19 DOI Open Access

Iwona Mazurkiewicz,

Żaneta Chatys-Bogacka,

Joanna Słowik

и другие.

Neurologia i Neurochirurgia Polska, Год журнала: 2023, Номер 57(1), С. 101 - 110

Опубликована: Фев. 22, 2023

Язык: Английский

Процитировано

4
SARS-COV-2 induces blood-brain barrier and choroid plexus barrier impairments and vascular inflammation in mice DOI Open Access

Haowen Qiao,

Xiangxue Deng,

Lingxi Qiu

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Фев. 10, 2024

Abstract The coronavirus disease of 2019 (COVID-19) pandemic that has led to more than 700 million confirmed cases and near 7 deaths. Although Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus mainly infects the respiratory system, neurological complications are widely reported in both acute infection long-COVID cases. Despite success vaccines antiviral treatments, neuroinvasiveness SARS-CoV-2 remains as an important question, which is also centered on mystery whether capable breaching barriers into central nervous system. By studying K18-hACE2 model, we observed clear evidence microvascular damage breakdown blood-brain barrier (BBB). Mechanistically, caused pericyte damage, tight junction loss, endothelial activation vascular inflammation, together drive injury BBB impairment. In addition, blood-cerebrospinal fluid at choroid plexus was impaired after infection. Therefore, cerebrovascular dysfunctions aspects COVID-19 may contribute acutely long COVID.

Язык: Английский

Процитировано

1
Unmasking the long-term effects: unravelling neuropsychiatric and neurological consequences of COVID-19 DOI Open Access
Mahnoor Tariq,

FNU Mahak,

Rahul Kumar

и другие.

Annals of Medicine and Surgery, Год журнала: 2024, Номер 86(3), С. 1490 - 1495

Опубликована: Янв. 4, 2024

The COVID-19 pandemic has not only burdened healthcare systems but also led to a new emerging medical enigma that is post-COVID-19 syndrome or “long COVID.” Characterized by persistent symptoms extend beyond the acute phase of illness, long COVID rapidly become public health concern with ambiguous neurological and neuropsychiatric dimensions. This narrative review aims at synthesizing available research decode long-term impacts on mental health. Drawing from multitude studies, this synthesizes evidence various symptoms, including cognitive deficits, mood disorders, more. delves into potential pathogenic mechanisms, hoping fill existing gaps offering directions for future inquiry. objective just academic; it immediate real-world implications. Understanding these effects crucial developing effective treatments interventions, thereby better serving millions individuals living lingering symptoms. As continue grapple fallout pandemic, provides much-needed context insights an area demands urgent action.

Язык: Английский

Процитировано

1