The quest for a biological phenotype of adolescent non-suicidal self-injury: a machine-learning approach
Translational Psychiatry,
Год журнала:
2024,
Номер
14(1)
Опубликована: Янв. 25, 2024
Abstract
Non-suicidal
self-injury
(NSSI)
is
a
transdiagnostic
psychiatric
symptom
with
high
prevalence
and
relevance
in
child
adolescent
psychiatry.
Therefore,
it
of
great
interest
to
identify
biological
phenotype
associated
NSSI.
The
aim
the
present
study
was
cross-sectionally
investigate
patterns
markers
underlying
NSSI
psychopathology
sample
female
patients
healthy
controls.
Comprehensive
clinical
data,
saliva
blood
samples,
heart
rate
variability
pain
sensitivity,
were
collected
n
=
149
40
participants.
Using
machine-based
learning,
we
tested
extent
which
oxytocin,
dehydroepiandrosterone
(DHEA),
beta-endorphin,
free
triiodothyronine
(fT3),
leukocytes,
sensitivity
able
classify
participants
regarding
their
outcomes
NSSI,
depression
borderline
personality
disorder
symptomatology.
We
evaluated
predictive
performance
several
models
(linear
logistic
regression,
elastic
net
random
forests,
gradient
boosted
trees)
using
repeated
cross-validation.
With
as
an
outcome
variable,
both
regression
machine
learning
showed
moderate
(Area
under
Receiver
Operating
Characteristic
Curve
between
0.67
0.69).
Predictors
highest
power
low
oxytocin
(OR
0.55;
p
0.002),
1.15;
0.021),
leukocytes
1.67;
0.015).
For
psychopathological
variables,
i.e.,
symptomatology,
including
variables
performed
not
better
than
null
model.
A
combination
hormonal
inflammatory
markers,
well
discriminate
without
disorder.
Based
on
this
dataset,
however,
complex
detect
non-linear
associations
markers.
These
findings
need
replication
future
research
will
reveal
respective
biomarkers
are
useful
for
longitudinal
prediction
or
treatment
response.
Язык: Английский
Social and Emotional Learning and Physical Health Outcomes Across the Lifespan: Little Progress & Big Potential
Social and Emotional Learning Research Practice and Policy,
Год журнала:
2025,
Номер
unknown, С. 100108 - 100108
Опубликована: Апрель 1, 2025
Язык: Английский
Differential Regulation of Circadian Clock Genes by UV-B Radiation and 1,25-Dihydroxyvitamin D: A Pilot Study during Different Stages of Skin Photocarcinogenesis
Nutrients,
Год журнала:
2024,
Номер
16(2), С. 254 - 254
Опубликована: Янв. 14, 2024
Background:
Increasing
evidence
points
at
an
important
physiological
role
of
the
timekeeping
system,
known
as
circadian
clock
(CC),
regulating
not
only
our
sleep–awake
rhythm
but
additionally
many
other
cellular
processes
in
peripheral
tissues.
It
was
shown
various
cell
types
that
environmental
stressors,
including
ultraviolet
B
radiation
(UV-B),
modulate
expression
genes
regulate
CC
(CCGs)
and
these
CCGs
susceptibility
for
UV-B-induced
damage.
aim
this
pilot
study
to
gain
further
insights
into
CCs’
putative
photocarcinogenesis
skin
cancer.
Methods:
Applying
RT-PCR,
we
analyzed
two
core
(brain
muscle
ARNT-like
1
(Bmal1)
Period-2
(Per2))
over
several
time
(0–60
h)
HaCaT
cells
with
without
1,25-dihydroxyvitamin
D
(D3)
and/or
UV-B
conducted
a
cosinor
analysis
evaluate
effects
those
conditions
on
extended
mixed-effects
linear
modeling
account
both
fixed
experimental
random
inter-individual
variability.
Next,
investigated
keratinocytes
representing
different
stages
photocarcinogenesis,
comparing
normal
(Normal
Human
Epidermal
Keratinocytes—NHEK;
p53
wild
type),
precancerous
(HaCaT
keratinocytes;
mutated
status),
malignant
(Squamous
Cell
Carcinoma
SCL-1;
null
status)
after
12
h
under
same
conditions.
Results:
We
demonstrated
cells,
Bmal1
showed
robust
rhythm,
while
Per2
limited.
Overall
genes,
especially
Bmal1,
increased
following
treatment,
suppressed
overall
D3.
Both
UVB
1,25(OH)2D3
suggested
significant
phase
shift
(p
<
0.05
acrophase),
no
specific
effect
amplitude
could
be
evidenced.
Differential
BMAL1
were
found
when
compared
treatment
modalities
(UV-B
D3)
or
(NHEK,
HaCaT,
SCL-1
cells).
Conclusions:
Comparing
epidermal
provide
independently
operating
system
human
skin,
which
is
regulated
by
disturbed
during
photocarcinogenesis.
Our
finding
pattern
differentially
altered
UV-B,
D3,
does
support
hypothesis
may
via
synthesis
vitamin
might
introducing
novel
photoprotective
property
through
clock.
Язык: Английский
Digital Phenotyping for Real-Time Monitoring of Nonsuicidal Self-Injury: Protocol for a Prospective Observational Study
JMIR Research Protocols,
Год журнала:
2024,
Номер
13, С. e53597 - e53597
Опубликована: Янв. 18, 2024
Background
Nonsuicidal
self-injury
(NSSI)
is
a
major
global
health
concern.
The
limitations
of
traditional
clinical
and
laboratory-based
methodologies
are
recognized,
there
pressing
need
to
use
novel
approaches
for
the
early
detection
prevention
NSSI.
Unfortunately,
still
lack
basic
knowledge
descriptive
nature
on
NSSI,
including
when,
how,
why
occurs
in
everyday
life.
Digital
phenotyping
offers
potential
predict
prevent
NSSI
by
assessing
objective
ecological
measurements
at
multiple
points
time.
Objective
This
study
aims
identify
real-time
predictors
explain
an
individual’s
dynamic
course
Methods
will
hybrid
approach,
combining
elements
prospective
observational
research
with
non–face-to-face
methods.
recruit
cohort
150
adults
aged
20
29
years
who
have
self-reported
engaging
5
or
more
days
within
past
year.
Participants
be
enrolled
longitudinal
conducted
3-month
intervals,
spanning
3
long-term
follow-up
phases.
momentary
assessment
(EMA)
technique
used
via
smartphone
app.
prompted
complete
suicidality
questionnaire
mood
appraisal
times
day
duration
14
days.
A
wrist-worn
wearable
device
collect
heart
rate,
step
count,
sleep
patterns
from
participants.
Dynamic
structural
equation
modeling
machine
learning
used.
Results
Participant
recruitment
data
collection
started
October
2023.
Data
analysis
expected
completed
December
2024.
results
published
peer-reviewed
journal
presented
scientific
conferences.
Conclusions
insights
gained
this
not
only
shed
light
underlying
mechanisms
but
also
pave
way
development
tailored
culturally
sensitive
treatment
options
that
can
effectively
address
mental
International
Registered
Report
Identifier
(IRRID)
DERR1-10.2196/53597
Язык: Английский
Exploring emotions beyond the laboratory: A review of emotional and physiological ecological momentary assessment methods in children and youth
Psychophysiology,
Год журнала:
2024,
Номер
61(12)
Опубликована: Окт. 4, 2024
Abstract
Recent
advancements
in
methodologies
such
as
ecological
momentary
assessment
(EMA)
and
ambulatory
physiology
devices
have
enhanced
our
ability
to
measure
emotions
experienced
daily
life.
Despite
the
feasibility
of
EMA
for
assessing
children's
youth's
emotional
self‐reports,
combining
it
with
physiological
measurements
a
real‐life
context
has
yet
be
established.
Our
scoping
review
evaluates
usability
implementing
children
youth.
Due
complexities
data,
this
also
synthesized
existing
methodological
statistical
practices
studies.
Following
PRISMA‐ScR
guidelines,
we
searched
screened
PsycINFO,
PubMed,
Web
Science
electronic
databases
studies
that
assessed
subjective
cardiac
or
electrodermal
responses
outside
laboratory.
initial
search
resulted
4174
studies,
13
which
were
included
review.
Findings
showed
significant
variability
EMA,
device
wear‐time
averaging
58.77%
study
periods
data
loss
due
quality
issues
ranging
from
0.2%
77%
across
signals.
Compliance
was
approximately
60%
when
combined
EMA.
The
points
lack
standardized
procedures
suggests
need
guidelines
designing,
processing,
analyzing
collected
contexts.
We
offer
recommendations
enhance
participant
engagement
develop
standard
employing
youth
emotion,
developmental,
psychophysiology
researchers.
Язык: Английский
From pathogenesis of stress-related mental disorders to treatment: beyond the brain
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2024,
Номер
274(3), С. 473 - 474
Опубликована: Март 22, 2024
Язык: Английский
A cross-sectional study of non-suicidal self-injury in adults with depressive disorder: Associations with inflammation and cardiac structure and function
Journal of Psychosomatic Research,
Год журнала:
2024,
Номер
187, С. 111944 - 111944
Опубликована: Сен. 28, 2024
Язык: Английский
Effects of long-term transcutaneous auricular vagus nerve stimulation on circadian vagal activity in people with Prader-Willi Syndrome: A case-series
Research in Developmental Disabilities,
Год журнала:
2024,
Номер
154, С. 104855 - 104855
Опубликована: Окт. 13, 2024
Язык: Английский
Autonomic Nervous System Function in Nonsuicidal Self-Injury—A Research Domain Criteria Perspective on the Arousal/Regulatory Systems
Oxford University Press eBooks,
Год журнала:
2023,
Номер
unknown, С. 349 - 376
Опубликована: Март 22, 2023
Abstract
This
chapter
addresses
autonomic
nervous
system
(ANS)
function
in
nonsuicidal
self-injury
(NSSI)
from
the
perspective
of
Research
Domain
Criteria
(RDoC).
Based
on
RDoC
framework,
ANS,
as
a
major
stress-regulatory
humans,
is
primarily
considered
to
be
implicated
domain
arousal/regulatory
systems,
while
it
shows
associations
also
other
domains.
Drawing
recent
theoretical
models
providing
framework
for
understanding
neurobiology
NSSI,
suggested
that
NSSI
may
result
failures
physiological
and
socioemotional
stress
regulation.
In
present
chapter,
after
introducing
ANS
under
outlining
potential
rationale
an
involvement
central
mechanisms
concepts
will
presented
help
understand
how
typically
context
psychophysiological
research
studies.
Further,
overview
indices
are
frequently
derived
lab
quantify
provided.
The
then
reviews
existing
studies
where
respective
have
been
measured
study
different
temporal
angles
(i.e.,
resting
state,
response
stress,
well
considering
its
diurnal
rhythmicity).
On
basis
evidence
reviewed,
discusses
current
state
field
concludes
with
short
summary
outlook
highlighting
avenues
future
research.
Язык: Английский
Digital Phenotyping for Real-Time Monitoring of Nonsuicidal Self-Injury: Protocol for a Prospective Observational Study (Preprint)
Опубликована: Окт. 11, 2023
BACKGROUND
Nonsuicidal
self-injury
(NSSI)
is
a
major
global
health
concern.
The
limitations
of
traditional
clinical
and
laboratory-based
methodologies
are
recognized,
there
pressing
need
to
use
novel
approaches
for
the
early
detection
prevention
NSSI.
Unfortunately,
still
lack
basic
knowledge
descriptive
nature
on
NSSI,
including
when,
how,
why
occurs
in
everyday
life.
Digital
phenotyping
offers
potential
predict
prevent
NSSI
by
assessing
objective
ecological
measurements
at
multiple
points
time.
OBJECTIVE
This
study
aims
identify
real-time
predictors
explain
an
individual’s
dynamic
course
METHODS
will
hybrid
approach,
combining
elements
prospective
observational
research
with
non–face-to-face
methods.
recruit
cohort
150
adults
aged
20
29
years
who
have
self-reported
engaging
5
or
more
days
within
past
year.
Participants
be
enrolled
longitudinal
conducted
3-month
intervals,
spanning
3
long-term
follow-up
phases.
momentary
assessment
(EMA)
technique
used
via
smartphone
app.
prompted
complete
suicidality
questionnaire
mood
appraisal
times
day
duration
14
days.
A
wrist-worn
wearable
device
collect
heart
rate,
step
count,
sleep
patterns
from
participants.
Dynamic
structural
equation
modeling
machine
learning
used.
RESULTS
Participant
recruitment
data
collection
started
October
2023.
Data
analysis
expected
completed
December
2024.
results
published
peer-reviewed
journal
presented
scientific
conferences.
CONCLUSIONS
insights
gained
this
not
only
shed
light
underlying
mechanisms
but
also
pave
way
development
tailored
culturally
sensitive
treatment
options
that
can
effectively
address
mental
INTERNATIONAL
REGISTERED
REPORT
DERR1-10.2196/53597
Язык: Английский