Comorbidities of hypothyroidism
Current Medical Research and Opinion,
Год журнала:
2025,
Номер
unknown, С. 1 - 17
Опубликована: Март 11, 2025
Hypothyroidism
is
a
relatively
common
condition
that
may
affect
as
many
10%
of
the
population
worldwide
when
its
overt
and
subclinical
presentations
are
considered.
Important
clinical
comorbidities
highly
prevalent
in
people
with
hypothyroidism
diminish
quality
life
functional
status
manner
proportional
to
number
present
their
severity.
This
article
reviews
hypothyroidism,
reported
literature.
The
include
conditions
commonly
associated
such
dyslipidaemia,
hypertension,
fatigue
or
(possibly)
cardiovascular
disease,
can
appear
whether
not
intervention
LT4
applied
appropriately
ensure
biochemical
euthyroidism.
Other
share
some
pathogenetic
background
including
depression
anxiety,
autoimmune
conditions.
arise
comorbidity
other
conditions,
e.g.
following
application
targeted
cancer
therapies
alemtuzumab
for
multiple
sclerosis.
treatments,
metformin,
glucocorticoids
proton
pump
inhibitors
among
others,
alter
levels
thyrotropin,
thus
impacting
on
monitoring
thyroid
dysfunction
diagnosis
dysfunction.
Ensuring
good
control
necessary
first
step
managing
any
patient
hypothyroidism.
Then,
physicians
should
be
aware
possibility
comorbid
must
addressed
achieve
an
optimal
outcome.
Язык: Английский
Exploring the interaction effects of subclinical hypothyroidism and major depressive disorder on brain networks
BMC Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Март 26, 2025
Major
depressive
disorder
(MDD)
often
presents
alongside
physical
illnesses,
such
as
a
high
incidence
of
subclinical
hypothyroidism
(SHypo)
in
patients,
highlighting
the
common
occurrence
these
comorbidities.
Recent
research
has
indicated
that
presence
comorbid
SHypo
individuals
diagnosed
with
MDD
may
result
notable
alterations
both
brain
structure
and
function.
This
study
aimed
was
to
investigate
neurological
mechanisms
underlying
this
co-occurrence
using
data-driven
approach
analyze
activity
patterns.
Twenty-nine
patients
without
any
conditions
(nSHypo-MDD)
were
included
study,
along
29
who
also
had
(SHypo-MDD),
26
only,
healthy
controls
(HCs).
Each
participant
received
resting-state
functional
magnetic
resonance
imaging
scans
underwent
neuropsychological
evaluations.
We
found
significantly
altered
connectivity
(FC)
within
networks
(RSNs)
ventral
dorsal
sensorimotor
network
(VSMN
DSMN)
occipital
pole
visual
(PVN)
(p
<
0.05,
FDR
corrected).
A
vital
interaction
effect
between
detected
PVN,
showing
SHypo-MDD
higher
FC
values
left
cuneus
than
nSHypo-MDD
patients.
Serum-free
triiodothyronine
(FT3)
levels
demonstrated
an
inverse
relationship
right
supplementary
motor
area
(SMA.R)
(r
=
−
0.563,
p
0.003).
Furthermore,
are
positively
associated
Digit
Symbol
Substitution
Test
(DSST)
scores
0.507,
0.008).
Our
reveals
significant
changes
particularly
VSMN,
DSMN,
suggesting
compensatory
mitigate
cognitive
deficits
need
for
integrated
management
improve
outcomes.
Язык: Английский
Prevalence and clinical correlates of suicide attempts in patients with first-episode drug-naïve major depressive disorder and comorbid autoimmune thyroiditis
BJPsych Open,
Год журнала:
2024,
Номер
10(3)
Опубликована: Апрель 30, 2024
Background
Autoimmune
thyroiditis
is
closely
associated
with
major
depressive
disorder
(MDD)
and
suicide
attempts.
However,
few
studies
have
examined
this
relationship.
Aims
The
study
aimed
to
assess
the
prevalence
correlates
of
attempts
in
patients
first-episode
drug-naïve
(FEDN)
MDD
autoimmune
thyroiditis.
Method
We
recruited
1718
out-patients
FEDN
assessed
depressive,
anxiety
psychotic
symptoms
Hamilton
Rating
Scale
for
Depression,
Anxiety
(HRSA)
Positive
Negative
Syndrome
Subscale
positive
subscale,
respectively.
serum
levels
free
triiodothyronine,
thyroxine,
thyroid
stimulating
hormone
(TSH),
antithyroglobulin,
peroxidase
antibody
(TPOAb)
several
other
metabolic
parameters
were
assessed.
Patients
divided
into
non-autoimmune
thyroiditis,
only
abnormal
TSH
groups,
based
on
severity.
Multiple
logistic
regression
model
was
applied
identify
TSH.
Results
Compared
group,
group
had
a
nearly
fourfold
higher
likelihood
reporting
attempt,
whereas
no
difference
found
between
groups.
HRSA
score,
lnTPOAb
lnTSH
independently
Conclusions
are
at
risk
attempt.
TPOAb,
all
population,
regular
checks
warranted.
Язык: Английский
Suicidal ideation in Chinese patients with chronic schizophrenia: prevalence, clinical correlates, and relationship with alexithymia
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2023,
Номер
274(7), С. 1509 - 1516
Опубликована: Июнь 13, 2023
Язык: Английский
Positive association between increased homocysteine and deficit syndrome in Chinese patients with chronic schizophrenia: a large-scale cross-sectional study
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2023,
Номер
274(5), С. 1105 - 1113
Опубликована: Ноя. 9, 2023
Язык: Английский
Subclinical hypothyroidism and metabolic syndrome in psychiatric patients: A systematic literature review and meta-analysis
The The Aung,
Win Wah,
Arnob Chakraborti
и другие.
Australasian Psychiatry,
Год журнала:
2024,
Номер
32(5), С. 470 - 476
Опубликована: Июль 24, 2024
Objective
The
systematic
review
evaluated
the
association
of
subclinical
hypothyroidism
(SCH)
with
metabolic
syndrome
(MetS)
and
specific
MetS
components
in
people
major
psychiatric
disorders.
Methods
A
meta-analysis
was
conducted
to
evaluate
SCH
its
conditions.
Results
Five
studies
incorporating
24,158
participants
met
inclusion
criteria.
All
five
comprised
patients
depression
and/or
anxiety.
Three
3365
were
suitable
for
meta-analysis.
pooled
Odds
Ratio
(OR)
3.46
(95%
Confidence
Interval/CI
=
1.39–8.62)
depressive
disorder
(MDD)
anxiety
disorders
concurrent
compared
those
without
SCH.
Meta-analysis
showed
a
significant
positive
between
high
body
mass
index
(OR
2.58,
95%CI
1.33–5.01),
fasting
plasma
glucose
3.05,
1.79–5.18)
low
high-density
lipoprotein
cholesterol
2.30,
1.82–2.92).
Conclusions
These
findings
suggest
MDD
This
informed
clinical
implications
comorbid
importance
early
diagnosis
treatment
patients.
Язык: Английский
From pathogenesis of stress-related mental disorders to treatment: beyond the brain
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2024,
Номер
274(3), С. 473 - 474
Опубликована: Март 22, 2024
Язык: Английский
Body fat, lipid profile and selected hormones in active male Polish students characterized by lower and higher normal thyroid-stimulating hormone levels
Biomedical Human Kinetics,
Год журнала:
2024,
Номер
16(1), С. 278 - 284
Опубликована: Янв. 1, 2024
Abstract
Study
aim
:
To
evaluate
the
relationship
between
body
fat,
lipid
profile
and
selected
hormones
in
context
of
lower
higher
normal
thyroid-stimulating
hormone
(TSH)
levels
active
male
students.
Material
methods
A
total
112
students
Faculty
Physical
Education
volunteered
to
participate
study.
Body
weight,
height
waist
circumference
were
measured
using
standard
medical
equipment.
The
percentage
fat
was
determined
from
sum
thickness
four
skinfolds.
Circulating
lipids,
TSH,
glucose
insulin
level
measured.
Results
Biochemical
characteristics
revealed
that
circulating
cholesterol
(TC),
low-density
lipoprotein
(LDL-C),
triacylglycerol
(TG)
significantly
with
TSH
vs.
levels.
analysis
distorted
metabolic
variables
indicated
for
frequency
disturbances
than
Additionally,
this
group
characterized
by
a
body.
Conclusion
In
young,
physically
men,
certain
disorders
related
plasma
profiles
may
be
observed
despite
Язык: Английский