Targeting the gut microbiota-inflammation-brain axis as a potential therapeutic strategy for psychiatric disorders: A Mendelian randomization analysis
Journal of Affective Disorders,
Год журнала:
2025,
Номер
374, С. 150 - 159
Опубликована: Янв. 13, 2025
Язык: Английский
Differential associations between cytokine and complement proteins in the clinical high risk and first episode stages of psychosis: Blood based investigation across three international studies of psychosis: NEURAPRO, STEP and OPTiMiSE
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 14, 2025
Abstract
Dysregulation
of
inflammatory
mediators
and
complement
cascade
proteins
has
been
implicated
in
psychosis.
In
the
current
study,
we
aimed
to
investigate
relationship
between
cytokines
blood
from
people
at
clinical
high
risk
(CHR)
for
psychosis
first
episode
(FEP).
Baseline
samples
two
cohorts
CHR
participants
[NEURAPRO
(n
=
153)
STEP
146)],
one
cohort
FEP
patients
[OPTiMiSE
226)]
were
included.
The
levels
three
Inflammatory
markers
including
Interleukin
(IL)-6,
Tumour
necrosis
factor-alpha
(TNF-α)
C-reactive
protein
(CRP)
along
with
about
30
considered
analyses.
First,
evaluated
interrelationship
then
using
regression
models,
investigated
their
association
proteins.
We
detected
positive
associations
among
all
IL-6,
TNF-α,
CRP
individuals,
whereas
was
observed
only
IL-6
TNF-α.
Regression
models
showed
strong
C3,
C4A,
C4B,
C5,
CFB
CFI
both
cohorts.
This
indicates
presence
a
related
pro-inflammatory
tone
developing
contrast,
cohort,
C1QA,
FCN-2,
MASP2
an
inverse
no
found
or
CRP.
These
results
suggest
switch
immune
activity
peripheral
circulation
compared
CHR.
novel
findings
propose
that
protein-targeted
anti-inflammatory
therapy
could
be
effective
state
hence
used
early
intervention
Язык: Английский
Impact of second-generation antipsychotics monotherapy or combined therapy in cytokine, lymphocyte subtype, and thyroid antibodies for schizophrenia: a retrospective study
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Окт. 16, 2024
Schizophrenia
(SCZ)
shares
high
clinical
relevance
with
the
immune
system,
and
potential
interactions
of
psychopharmacological
drugs
system
are
still
an
overlooked
area.
Here,
we
aimed
to
identify
whether
second-generation
antipsychotics
(SGA)
monotherapy
or
combined
therapy
SGA
other
psychiatric
medications
influence
routine
blood
immunity
biomarkers
patients
SCZ.
Язык: Английский
Shared polygenic susceptibility to treatment response in severe affective and psychotic disorders: Evidence from GWAS data sets
Progress in Neuro-Psychopharmacology and Biological Psychiatry,
Год журнала:
2024,
Номер
136, С. 111183 - 111183
Опубликована: Окт. 30, 2024
Язык: Английский
Variations in inflammatory regulators in male patients with chronic schizophrenia associated with psychopathology and cognitive deficits
BMC Psychiatry,
Год журнала:
2024,
Номер
24(1)
Опубликована: Ноя. 15, 2024
Immune
dysregulation
has
been
identified
as
a
contributing
factor
in
the
pathophysiology
of
schizophrenia.
This
study
aimed
to
investigate
variations
specific
immune
regulators
and
their
correlation
with
psychopathology
cognitive
functions
male
patients
chronic
Employing
cross-sectional
design,
this
included
72
The
Positive
Negative
Syndrome
Scale
(PANSS)
Repeatable
Battery
for
Assessment
Neuropsychological
Status
were
utilized
assess
functions,
respectively.
Serum
levels
interleukin
(IL)-4,
IL-10,
IL-12p40,
IL-13,
monocyte
chemoattractant
protein-1
(MCP-1)
measured.
There
significantly
increased
IL-4,
MCP-1,
alongside
decreased
IL-10
compared
controls
(all
P
<
0.05).
IL-4
showed
significant
negative
association
PANSS
positive
symptoms
(beta=-0.222,
=
0.042).
After
controlling
antipsychotic
medication,
BMI,
smoking,
was
no
longer
(r=-0.232,
0.055).
Additionally,
correlations
(beta
0.297,
0.008),
IL-13
0.371,
0.001),
MCP-1
0.280,
0.013)
language
scores
observed.
Increased
(P
0.044,
OR
1.994),
0.019,
2.245),
well
interactions
0.043,
2.000)
positively
associated
risk
schizophrenia,
while
lower
0.003,
0.2.867)
also
linked
an
risk.
associations
between
markers
clinical
features
schizophrenia
males
underscored
potential
immune-mediated
mechanisms
underlying
Язык: Английский