Association of the newly proposed dietary index for gut microbiota and constipation: a cross-sectional study from NHANES

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 17, 2025

The dietary index for gut microbiota. DI-GM is an innovative metric designed to capture the diversity of microbiome, yet its association with constipation remains unstudied. In this cross-sectional study, 11,405 adults aged 20 and older were selected from National Health Nutrition Examination Survey 2005-2010 sample. Constipation was defined as fewer than three defecation frequencies per week using bowel health questionnaire (BHQ). Fewer movements considered by Bowel Questionnaire derived recall data, including avocado, broccoli, chickpeas, coffee, cranberries, fermented dairy, fiber, green tea, soybean whole grains beneficial elements, red meat, processed refined grains, high fat detrimental components. Multivariable weighted logistic employed investigate constipation. Secondary analyses included subgroup analyses, restricted cubic spline (RCS), multiple imputation. A higher microbiota score associated a lower prevalence (DI-GM: OR = 0.82, 95% CI 0.75, 0.90; score: 0.77, 0.67, 0.89). After grouping DI-GM, in fully adjusted model, participants ≥ 6 significantly negatively correlated both (OR 0.48, 0.33, 0.71). RCS indicated non-linear relationship between Subgroup age, sex common complications showed no statistically significant interactions (p > 0.05). newly proposed inversely related When treating patients constipation, it necessary clinicians provide timely effective interventions incorporating avoid further deterioration condition.

Язык: Английский

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Association between the dietary index for gut microbiota and diabetes: the mediating role of phenotypic age and body mass index

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Янв. 22, 2025

Objectives The global prevalence of diabetes is continuously rising, and the gut microbiota closely associated with it. Dietary Index for Gut Microbiota (DI-GM) assesses impact diet on microbiota, but its association risk remains unclear. This study aims to investigate between DI-GM analyze mediating roles phenotypic age body mass index (BMI). Methods Utilizing data from National Health nutrition examination survey (NHANES) 1999–2018, we included 17,444 adults aged 20 years older. (score range: 0–13) was calculated based dietary recall. Diabetes diagnosed laboratory results self-reported information. Multivariable logistic regression used diabetes, adjusting relevant covariates. Mediation analysis evaluated BMI. Results After confounders, higher scores were significantly a lower (OR = 0.93, 95% CI 0.90–0.96, p < 0.001). Compared group 0–3, those 5 0.76, 0.67–0.86) ≥ 6 0.77, 0.68–0.88) had reduced risk. Phenotypic BMI accounted 41.02 25.57% respectively. Conclusion Higher are partially mediated through

Язык: Английский

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Dietary index for gut microbiota, a novel protective factor for the prevalence of chronic kidney diseases in the adults: insight from NHANES 2007–2018

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 19, 2025

Introduction This study explore the association between dietary index for gut microbiota (DI-GM) and prevalence of chronic kidney disease (CKD). Method A cross-sectional participants aged ≥20 years using data drawn from NHANES (2007–2018). DI-GM is comprised 14 components (10 beneficial 4 unfavorable). CKD diagnosis based on urine albumin-to-creatinine ratio (uACR) estimated glomerular filtration rate (eGFR). Logistic regression models were employed to evaluate relationship while controlling various covariates. Additionally, a spline smooth analysis was performed. Subgroup interaction analyses conducted investigate whether any factors modified this relationship. Results total 28,843 eligible study, whom 5,461 diagnosed with CKD, 23,382 not. Patients exhibited significantly lower scores compared healthy individuals. negative observed across all models, being more pronounced in individuals greater than 5 those ≤3. Beneficial components, such as fiber, whole grains, coffee, identified protective factors. Moreover, sex make an effect relationship, stronger effects noted women. Conclusion Higher correlate reduced prevalence, appears be women men. These findings suggest that enhancing health through diet may serve viable strategy prevention management particular attention sex-based differences prevention.

Язык: Английский

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Analysis of ASAS health index and its influencing factors in ankylosing spondylitis: a prospective study based on the population of Chaoshan region

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 8, 2025

This study aimed to evaluate the health-related quality of life (HRQoL) in ankylosing spondylitis (AS) patients Chaoshan region and identify factors influencing ASAS Health Index (ASAS-HI) enhance comprehensive AS treatment strategies. A survey ASAS-HI was conducted on 82 from rheumatology outpatient department First Affiliated Hospital Shantou University Medical College. The Bath Ankylosing Spondylitis Global Score (BAS-G) assessed overall health status, Quality Life Questionnaire (AS-QOL) evaluated life, Disease Activity (BASDAI) measured disease activity, Functional (BASFI) functional difficulties. Inflammatory markers patient data were collected, univariate/multivariate logistic regression analyses used explore ASAS-HI. mean score 3.52 ± 3.12. positively correlated with BASDAI (r = 0.478, p < 0.001), ASDAS-CRP 0.406, BASFI 0.338, 0.002), BAS-G 0.335, 0.002). Patients ASDAS-ESR ≥ 2.1, spinal tenderness had significantly higher scores than others (p 0.001). Spinal radiographic grading identified as key factors. is impacted by activity limitations. Early assessment crucial for optimizing management patients.

Язык: Английский

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Dietary index for gut microbiota is associated with stroke among US adults

Food & Function, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

The dietary index for gut microbiota was inversely associated with stroke prevalence, particularly in adults aged 30 years and above.

Язык: Английский

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National analysis of the dietary index for gut microbiota and kidney stones: evidence from NHANES (2007–2018)

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 13, 2025

Background Previous studies have highlighted the effects of diet and gut microbiota on incidence kidney stones, dietary index for (DI-GM) is a new that accurately represents variety microbiota. The current study intends to examine potential correlation between DI-GM stones. Methods Data from 2007–2018 National Health Nutrition Examination Survey (NHANES) were employed in this cross-sectional study. history stones was assessed using conditions questionnaire. In order multivariate logistic regression implemented. Additionally, smoothed curve fitting, subgroup analyses, sensitivity analyses conducted. Results investigation encompassed total 21,587 participants. After adjusting all covariates, we found negatively related (OR = 0.96, 95% CI 0.93–0.98, p 0.0021). Compared those lowest quartile, participants highest quartile had lower prevalence 0.86, 0.75–0.98, 0.0252). fitting revealed linearly associated with results proved robustness main analyses. Conclusion A negative supported by evidence presented This finding emphasizes benefits structure according reducing Further research should validate discovery employing longitudinal studies.

Язык: Английский

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The mediating role of biological age in the association between dietary index for gut microbiota and sarcopenia

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Март 21, 2025

Background Dietary Index of Gut Microbiota (DI-GM) is a newly proposed comprehensive metric for assessing dietary quality in relation to gut microbiota composition. Alterations muscle structure are closely linked DNA methylation-based biological age assessments and individual patterns. However, systematic investigation the interrelationships among DI-GM, age, sarcopenia remains lacking. We hypothesize that consuming foods beneficial may help mitigate risk by slowing aging process. Methods This study analyzed data from NHANES 2007–2018. DI-GM was calculated using two 24-hour recall datasets. Sarcopenia assessed via dual-energy X-ray absorptiometry (DXA). The association between evaluated multivariate logistic regression, subgroup analysis, restricted cubic splines. also investigated potential mediating effects three indicators: Klemera-Doubal Method (KDM), PhenoAge, Homeostatic Dysregulation (HD). Results An increase score significantly associated with reduced (OR: 0.87, 95% CI: 0.82–0.94).The lower highest quartile group (Q3) 0.25, 0.11–0.58). age-related indicators (KDM, PA, HD) partially mediated sarcopenia, PhenoAge showing mediation proportion at 30.6%. Conclusion A higher sarcopenia. HD, KDM demonstrated significant effects, proportion.

Язык: Английский

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Linear association of the dietary index for gut microbiota with insulin resistance and type 2 diabetes mellitus in U.S. adults: the mediating role of body mass index and inflammatory markers

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 21, 2025

Background Gut microbiota is reported to be related the onset of insulin resistance (IR) and type 2 diabetes mellitus (T2DM). The dietary index for gut (DI-GM) a novel reflecting diversity. We aimed evaluate association DI-GM with T2DM IR. Methods This cross-sectional research comprised 10,600 participants aged ≥20 from National Health Nutrition Examination Survey (NHANES) 2007–2018. employed weighted multivariable linear logistic regression models examine correlation Linear or nonlinear relationships were examined by restricted cubic spline (RCS) regression. Additionally, subgroup sensitivity analyses performed ensure reliability results. Mediation analysis explored roles body mass (BMI) inflammatory factors in these associations. Results Higher inversely associated (OR = 0.93, 95%CI: 0.89–0.98) IR 0.95, 0.91–0.99) after adjusting confounders. ≥ 6 group showed significantly lower risks 0.74, 0.60–0.91) 0.77, 0.62–0.95). RCS demonstrated relationship between T2DM, as well was also correlated risk markers T2DM. that BMI systemic inflammation response partly mediated IR, while immune-inflammation only Conclusion mediating this association.

Язык: Английский

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Association between dietary index for gut microbiota and self-reported severe headache or migraine in U.S. adults: a cross-sectional study from NHANES

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 31, 2025

The diet-microbiota-gut-brain axis is an emerging frontier in brain health, with microbiota-targeted dietary interventions offering potential benefits. This study aimed to explore the association between recently introduced index for gut microbiota (DI-GM) and self-reported severe headache or migraine U.S. adults. cross-sectional analyzed National Health Nutrition Examination Survey (NHANES) data from 1999 2004. Severe was determined based on participants' responses question: "Have you had a past 3 months?" DI-GM calculated recall data. Multivariable logistic regression models were performed evaluate odds ratio (OR) 95% confidence interval (95% CI) migraine. Secondary analyses included restricted cubic splines (RCS) subgroup analyses. After adjustments, higher score BGMS associated lower prevalence of (DI-GM: OR = 0.95, CI 0.91-0.99, p 0.011; BGMS: 0.90, 0.85-0.96, 0.003). RCS showed linear relationship In two-piecewise models, adjusted developing 0.90 0.85-0.97, 0.005) participants ≥ 4, whereas no observed those < 4. negatively adults, particularly when scores exceeded

Язык: Английский

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The association between Dietary Index for Gut Microbiota and sarcopenia: the mediating role of Dietary Inflammatory Index

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Март 31, 2025

Background Given the global changes in environmental and dietary habits, understanding potential impact of factors diet-related inflammation on skeletal muscle diseases, including sarcopenia, is crucial. Investigating these relationships can aid development more effective prevention strategies. This study used Dietary Index for Gut Microbiota (DI-GM) Inflammatory (DII) as variables. DI-GM a scoring system to assess influence diet health. Additionally, DII quantifies inflammatory diet. explores association between sarcopenia evaluates whether moderates this relationship. Methods conducted cross-sectional analysis 9,470 participants from 2011–2018 NHANES database. Multivariable logistic regression, restricted cubic splines (RCS), subgroup were employed examine prevalence sarcopenia. mediation was performed investigate associations DII, DI-GM, Results A total included study, whom 823 (7%) had After adjusting all variables using multivariable each one-unit increase associated with 15% decrease (OR = 0.85, 95% CI: 0.77, 0.94), while 28% 1.28, 1.17, 1.41). Furthermore, results remained robust when divided into tertiles. RCS revealed significant linear relationship The also showed that above robust. Mediation 55% mediated by ( P &lt; 0.001). Conclusion Adhering recommendations based may reduce appears mediate relationship, suggesting an anti-inflammatory could offer benefits.

Язык: Английский

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