Immunologiya, Год журнала: 2023, Номер 44(1), С. 63 - 71
Опубликована: Янв. 1, 2023
Клиническая иммунология
Язык: Русский
Clinical Pediatrics, Год журнала: 2021, Номер 61(2), С. 159 - 167
Опубликована: Ноя. 18, 2021
In this retrospective study of 319 children with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, we assessed whether age, asthma, obesity, diabetes, and socioeconomic status were associated hospitalization for disease 2019 (COVID-19). Demographic clinical characteristics using univariate statistics, excluding incidental or unrelated positives. There was a bimodal distribution age among hospitalized children. Obesity ( P < .001) past medical history diabetes = significantly more prevalent in children, including cases new-onset diabetic ketoacidosis. Neither asthma nor lower hospitalization. Although limited to single center, the findings may have important implications. Targeted, proactive health outreach obesity prioritization preventative efforts such as vaccination, be preventing worse SARS-CoV-2 infection vulnerable group.
Язык: Английский
Процитировано
29
Frontiers in Allergy, Год журнала: 2021, Номер 2
Опубликована: Июль 22, 2021
Asthma is a chronic respiratory condition characterised by episodes of shortness breath due to reduced airway flow. The disease triggered hyperreactive immune response innocuous allergens, leading hyper inflammation, mucus production, changes in structural cells lining the airways, and hyperresponsiveness. Asthma, although present adults, considered as childhood condition, with total about 6.2 million children aged 18 below affected globally. There has been progress understanding asthma heterogeneity which led better patient stratification characterisation multiple endotypes distinct, but overlapping inflammatory features. profile not well-defined less described. Although many factors such genetics, food allergies, antibiotic usage, type birth, cigarette smoke exposure can influence development particularly children, infections are thought be major contributing factor poor lung function onset disease. In this review, we focus on viral bacterial first 10 years life that could children. We also review literature asthmatic how overlaps early development, infections. Finally, animal studies model these inform future therapies complex
Язык: Английский
Процитировано
28
Pediatric Pulmonology, Год журнала: 2025, Номер 60(4)
Опубликована: Апрель 1, 2025
ABSTRACT Background Severe lung disease such as chronic pulmonary (CPD), severe asthma and cystic fibrosis (CF) in children is associated with increased risk of COVID‐19. Information regarding SARS‐CoV‐2 infection, severity outcome COVID‐19 limited this pediatric population. Objectives We captured the number infected evaluated non‐immunized CPD, asthma, CF a cohort at Danish tertiary center. Methods The PCR‐verified infection age‐related background population was identified through Microbiology Database. Clinical data were retrieved from electronic medical health records Health Authority. Results In 664 594 either PCR‐tested or had an antibody test for due to symptoms exposure 18 (3%) verified infection. total that time 34.575(4.342%) thus, not significantly different reference ( p = 0.152). ranged asymptomatic mild symptoms, none required hospitalization None treated antiviral treatment during acute Conclusion Of disease, hospitalized Our findings imply particular group patients do experience
Язык: Английский
Процитировано
0
Pediatric Allergy and Immunology, Год журнала: 2022, Номер 33(10)
Опубликована: Сен. 30, 2022
Abstract By the April 12, 2022, COVID‐19 pandemic had resulted in over half a billion people being infected worldwide. There have been 6.1 million deaths directly due to infection, but has many more short‐ and long‐term pervasive effects on physical mental health of population. Allergic diseases are among most prevalent noncommunicable chronic pediatric population, health‐care professionals researchers were seeking answers since beginning pandemic. Children at lower risk developing severe or dying from infection. not associated with higher severity mortality, apart severe/poorly controlled asthma. The disrupted routine care, mitigation strategies, including limited telemedicine, successfully implemented continue delivery high‐standard care. Although children faced multitude pandemic‐related issues, allergic conditions effectively treated remotely while reduction air pollution lack contact outdoor allergens improvement, particularly respiratory allergies. is no evidence recommend substantial changes usual management modalities children, allergen immunotherapy use biologicals. greater multisystem inflammatory syndrome development, some associations Long COVID reported, although data limited, further research needed. This statement EAACI Section Pediatrics provides recommendations based lessons learnt pandemic, as available evidence.
Язык: Английский
Процитировано
16
BMJ Open, Год журнала: 2022, Номер 12(3), С. e056549 - e056549
Опубликована: Март 1, 2022
To determine risk factors for SARS-CoV-2 infection and hospitalisation among children adolescents.Nationwide, population-based cohort study.Norway from 1 March 2020 to 30 November 2021.All Norwegian residents<18 years of age.Population-based healthcare population registries were used study infection, including socioeconomic factors, country origin pre-existing chronic comorbidities. All residents followed until age 18 years, emigration, death or end follow-up. HRs estimated by Cox regression models adjusted testing frequency. Further, admission the hospital infected investigated.Of 219 184 residents, 82 734 (6.7%) tested positive PCR lateral flow tests, whom 241 (0.29%) admitted a hospital. Low family income (adjusted HR (aHR) 1.26, 95% CI 1.23 1.30), crowded housing (1.27, 1.24 household size, age, non-Nordic (1.63, 1.60 1.66) area living independent infection. Chronic comorbidity was associated with slightly lower (aHR 0.90, 0.88 0.93). 3.46, 2.50 4.80), in addition whereas status did not predict those infected.Socioeconomic However, these infected. higher but overall acquiring SARS-CoV-2.
Язык: Английский
Процитировано
13
CHEST Journal, Год журнала: 2021, Номер 160(4), С. 1192 - 1199
Опубликована: Май 19, 2021
Язык: Английский
Процитировано
18
Frontiers in Pediatrics, Год журнала: 2024, Номер 12
Опубликована: Апрель 5, 2024
Background Cough is the most common respiratory symptom in children with mild coronavirus disease 2019 (COVID-19); however, evidence regarding duration and severity of COVID-19-related cough sparse. Herein, we investigated correlation between severity/duration allergic diseases following COVID-19. Methods This single-center, retrospective case-control study was conducted at Department Pediatrics, Peking University Third Hospital, from February 6–13, 2023. Children aged 0–16 completed a questionnaire survey collecting basic information weekly scores for 8 consecutive weeks after COVID-19 December 2022. The Kaplan–Meier method used to draw event curves, log-rank compare inter-group differences. Stepwise regression applied multivariate analysis correlations age, sex, diseases, degree Results Overall, 686 were included, whom 183 (26.7%) had 503 (73.3%) did not. identified significant differences patients without (log-rank test, P = 0.002) no those one more than 0.003). Multivariate link presence coughing >4 infection ( < 0.001). Allergic primary factor linked symptoms lasting Conclusions contributes prolonged
Язык: Английский
Процитировано
2
Narra J, Год журнала: 2024, Номер 4(2), С. e865 - e865
Опубликована: Авг. 8, 2024
This study investigated indicators of the severity and mortality COVID-19 in children Medan, Sumatera Utara Province, Indonesia. The aim this was to identify determinants outcome with as lesson learned from pandemic, particularly limited health facilities retrospective cohort conducted 2020, 2021, 2022 at multiple centers. Inpatient outpatient confirmed be SARS-CoV-2 positive were randomly recruited selected hospitals. Baseline data (demographic, clinical, laboratory radiological data) collected, outcomes classified recovered/deceased (for inpatient group) or returned hospital group). Severity status identified based on Indonesia guidelines. categorized according international standards analyzed using univariate analyzes followed by multivariate logistic regression. A total 303 114 included analysis. Out cases, nine patients died, 2.9 rate. Our final indicated that presence shortness breath (SOB), anemia, abnormal C-reactive protein (CRP) levels significantly associated emergency signs, while SOB comorbidities COVID-19. fever, cough, SOB, muscle ache diarrhea reasons why self-isolation home among cases; however, cough only significant factor mode. highlights important children, which should considered during clinical decision-making low-resource settings healthcare centers
Язык: Английский
Процитировано
2
International Journal of Environmental Research and Public Health, Год журнала: 2022, Номер 19(18), С. 11180 - 11180
Опубликована: Сен. 6, 2022
Epidemiological data concerning the level of asthma morbidity indicate that in Poland, is diagnosed 5-10% pediatric population. Aim The purpose this study was to compare prevalence respiratory symptoms and allergies a group children with without evaluate association between exposure environmental factors bronchial A cross-sectional conducted on 995 attending primary schools province Silesia 2018-2019. research tool an anonymous questionnaire developed based form used International Study Asthma Allergies Childhood (ISAAC). Children's health status, asthma, performance allergic skin tests were assessed parents' indications questionnaire. Environmental exposures such as mold dampness apartments or ETS similarly assessed. Analyses performed using Statistica 13.0; p < 0.05. total 88 subjects (8.8%) suffered from asthma. Parents compared parents disease, more likely rate their children's rather good (43.2% vs. 38.0%) average (21.6% 3.1%). All analyzed symptoms, well allergies, statistically frequent parent's subjective assessment child's varied significantly according diagnosis. also associated other diseases: reactions pollen, house dust, hay fever, AD (atopic dermatitis) among
Язык: Английский
Процитировано
11
Pathogens, Год журнала: 2023, Номер 12(2), С. 321 - 321
Опубликована: Фев. 15, 2023
For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T have been extensively investigated in regard to SARS-CoV-2 infection. However, human and cell responses are also impacted by many other pathogens chronic diseases. We summarized performance during coinfection with viruses, bacteria, parasites. Furthermore, we distinguished if those altered statuses under would affect their clinical outcomes, such as symptom severity hospitalization demand. alteration diabetes, asthma, hypertension patients infection was our study. whether changes response influence outcome comorbidities.
Язык: Английский
Процитировано
6