Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(13), С. 3886 - 3886
Опубликована: Июль 4, 2022
Fatigue
is
one
of
the
most
disabling
symptoms
in
several
neurological
disorders
and
has
an
important
cognitive
component.
However,
relationship
between
self-reported
fatigue
objective
assessment
results
remains
elusive.
Patients
with
post-COVID
syndrome
often
report
issues
months
after
acute
infection.
We
aimed
to
develop
predictive
models
using
neuropsychological
assessments
evaluate
results.
conducted
a
cross-sectional
study
113
patients
syndrome,
assessing
them
Modified
Impact
Scale
(MFIS)
comprehensive
battery
including
standardized
computerized
tests.
Several
machine
learning
algorithms
were
developed
predict
MFIS
scores
(total
score
score)
based
on
test
scores.
showed
moderate
correlations
only
Stroop
Color–Word
Interference
Test.
Classification
obtained
modest
F1-scores
for
classification
non-fatigued
or
3
4
degrees
severity.
Regression
estimate
did
not
achieve
adequate
R2
metrics.
Our
find
reliable
predictors
syndrome.
This
implications
interpretation
assessment.
Specifically,
domain
could
properly
capture
actual
fatigue.
In
addition,
our
findings
suggest
different
pathophysiological
mechanisms
dysfunction
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Апрель 22, 2024
Introduction:
Although
post-COVID-19
syndrome
(PCS)
with
cognitive
impairment
is
increasingly
encountered
in
primary
care,
evidence-based
recommendations
for
its
appropriate
management
are
lacking.
Methods:
A
systematic
literature
search
evaluating
the
diagnosis
and
treatment
of
associated
PCS
was
conducted.
Practical
PCS-associated
care
summarized,
based
on
an
evaluation
pharmacological
plausibility
clinical
applications.
Results:
Currently,
pathology
remains
unclear
no
high-quality
data
to
support
targeted
interventions.
Existing
approaches
directed
towards
symptom
relief
where
counseling
chronicity
disease
regular
reassessments
at
4-
8-week
intervals
considered
reasonable.
Patients
should
be
informed
encouraged
adopt
a
healthy
lifestyle
that
centers
around
balanced
nutrition
physical
activities.
They
may
also
benefit
from
intake
vitamins,
micronutrients,
probiotics.
The
administration
Ginkgo
biloba
extract
could
offer
safe
potentially
beneficial
option.
Other
non-pharmacological
measures
include
physiotherapy,
digitally
supported
training,
and,
if
indicated,
ergotherapy
or
speech
therapy.
In
most
patients,
symptoms
improve
within
8
weeks.
If
serious,
ambiguous,
when
new
occur,
specialized
diagnostic
such
as
comprehensive
neurocognitive
testing
neuroimaging
initiated.
Very
few
patients
would
require
inpatient
rehabilitation.
Conclusion:
debilitating
condition
affect
daily
functioning
reduce
work
productivity.
Management
multidisciplinary
approach,
centering
physical,
cognitive,
therapies.
PLoS ONE,
Год журнала:
2025,
Номер
20(1), С. e0312351 - e0312351
Опубликована: Янв. 28, 2025
Background
While
mental
health
alterations
during
active
COVID-19
infection
have
been
documented,
the
prevalence
of
long-term
consequences
remains
unclear.
This
study
aimed
to
determine
symptoms—depression,
anxiety,
stress,
and
suicidal
tendencies—and
identify
their
trends
associated
risk
factors
in
individuals
with
long-COVID.
Methods
We
conducted
a
systematic
literature
search
databases
including
PubMed,
EMBASE,
Scopus,
CINAHL,
Cochrane
Library,
Web
Science,
PsycINFO
up
August
2024,
targeting
observational
studies
published
English.
Study
quality
was
assessed
using
structured
standard
tools.
The
primary
outcome
pooled
depression,
tendencies
Secondary
outcomes
included
these
problems
over
time
identification
determinants.
Results
A
total
94
eligible
were
analysis.
estimates,
regardless
follow
times
duration,
as
follows:
25%
(95%CI:22–28%;
PI:1–59%);
anxiety
(adjusted
via
trim
fill
method),
23%(95%CI:21–25%;PI:2–35%);
composite
depression
and/or
(95%CI:23–27%;PI:2–51%);
26%(95%CI:13–39%;PI:1–69%);
suicidality,
19%(95%CI:15–22%;PI:13–25%).
results
meta-regression
analyses
revealed
statistically
significant
trend
showing
gradual
decrease
(RD
=
-0.004,P
0.022).
Meta-regression
indicated
that
being
female
younger
age
significantly
higher
symptoms.
design
setting
did
not
contribute
heterogeneity.
Conclusion
One-fourth
individual
long-COVID
experience
symptoms,
which
remain
prevalent
even
two
years
post-infection
despite
slight
decreasing
trend.
Factors
such
gender
linked
rates
depression.
These
findings
indicate
need
for
ongoing
screening
early
interventions
mitigate
psychological
distress
patients.
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(13), С. 3886 - 3886
Опубликована: Июль 4, 2022
Fatigue
is
one
of
the
most
disabling
symptoms
in
several
neurological
disorders
and
has
an
important
cognitive
component.
However,
relationship
between
self-reported
fatigue
objective
assessment
results
remains
elusive.
Patients
with
post-COVID
syndrome
often
report
issues
months
after
acute
infection.
We
aimed
to
develop
predictive
models
using
neuropsychological
assessments
evaluate
results.
conducted
a
cross-sectional
study
113
patients
syndrome,
assessing
them
Modified
Impact
Scale
(MFIS)
comprehensive
battery
including
standardized
computerized
tests.
Several
machine
learning
algorithms
were
developed
predict
MFIS
scores
(total
score
score)
based
on
test
scores.
showed
moderate
correlations
only
Stroop
Color–Word
Interference
Test.
Classification
obtained
modest
F1-scores
for
classification
non-fatigued
or
3
4
degrees
severity.
Regression
estimate
did
not
achieve
adequate
R2
metrics.
Our
find
reliable
predictors
syndrome.
This
implications
interpretation
assessment.
Specifically,
domain
could
properly
capture
actual
fatigue.
In
addition,
our
findings
suggest
different
pathophysiological
mechanisms
dysfunction
