Internal Medicine Journal,
Год журнала:
2024,
Номер
54(7), С. 1056 - 1065
Опубликована: Июнь 5, 2024
Normal-anion-gap
metabolic
acidosis
(NAGMA)
is
a
common
but
often
under-recognised
and
poorly
understood
condition,
especially
by
less-experienced
clinicians.
In
adults,
NAGMA
might
be
an
initial
clue
to
more
significant
underlying
pathology,
such
as
autoimmune
diseases,
hypergammaglobulinemia
or
drug
toxicities.
However,
identifying
the
aetiology
can
challenging
due
diverse
processes
involved
in
development
of
acidosis.
A
better
understanding
pathophysiology
help
treating
physicians
suspect
evaluate
condition
early
reach
correct
diagnosis.
This
article
provides
overview
renal
acid-base
regulation,
discusses
pathophysiological
developing
framework
for
evaluation
accurate
Toxicological Sciences,
Год журнала:
2023,
Номер
196(1), С. 52 - 70
Опубликована: Авг. 8, 2023
Microphysiological
systems
are
an
emerging
area
of
in
vitro
drug
development,
and
their
independent
evaluation
is
important
for
wide
adoption
use.
The
primary
goal
this
study
was
to
test
reproducibility
robustness
a
renal
proximal
tubule
microphysiological
system,
OrganoPlate
3-lane
40,
as
model
transport
toxicity
studies.
This
microfluidic
compared
with
static
multiwell
cultures
tested
using
several
human
epithelial
cell
(RPTEC)
types.
characterized
terms
the
functional
various
tubule-specific
proteins,
permeability
small
molecules
(cisplatin,
tenofovir,
perfluorooctanoic
acid)
versus
large
(fluorescent
dextrans,
60-150
kDa),
gene
expression
response
nephrotoxic
xenobiotic.
advantages
offered
by
40
presence
media
flow,
albeit
intermittent,
increased
throughput
other
models.
However,
appeared
offer
only
limited
(eg,
MRP-mediated
transport)
either
or
when
plate
culture
conditions.
Although
can
be
used
cellular
uptake
direct
toxic
effects
molecules,
it
may
have
utility
Overall,
offers
refined
experimental
protocols
comprehensive
comparative
data
on
function
RPETCs
traditional
information
that
will
invaluable
prospective
end-users
models
tubule.
AJP Renal Physiology,
Год журнала:
2024,
Номер
326(6), С. F894 - F916
Опубликована: Апрель 18, 2024
Mild
cognitive
impairment
(MCI)
is
common
in
people
with
chronic
kidney
disease
(CKD),
and
its
prevalence
increases
progressive
loss
of
function.
MCI
characterized
by
a
decline
performance
greater
than
expected
for
an
individual
age
education
level
but
minimal
instrumental
activities
daily
living.
Deterioration
can
affect
one
or
several
domains
(attention,
memory,
executive
functions,
language,
perceptual
motor
social
cognition).
Given
the
increasing
disease,
more
CKD
will
also
develop
causing
enormous
burden
these
individuals,
their
relatives,
society.
However,
underlying
pathomechanisms
are
poorly
understood,
current
therapies
mostly
aim
at
supporting
patients
lives.
This
illustrates
urgent
need
to
elucidate
pathogenesis
potential
therapeutic
targets
test
novel
appropriate
preclinical
models.
Here,
we
outline
necessary
criteria
experimental
modeling
disorders
CKD.
We
discuss
use
mice,
rats,
zebrafish
as
model
systems
present
valuable
techniques
through
which
function
be
assessed
this
setting.
Our
objective
enable
researchers
overcome
hurdles
accelerate
research
aimed
improving
therapy
MCI.
Heliyon,
Год журнала:
2025,
Номер
11(2), С. e41624 - e41624
Опубликована: Янв. 1, 2025
This
study
aimed
to
determine
whether
C.
mannii
seed
oil
(CMSO)
could
shield
rats
from
cyclophosphamide-induced
hepatorenal
toxicity.
The
focus
was
on
its
antioxidant
and
anti-inflammatory
properties.
We
randomly
assigned
thirty-six
(36)
male
Wistar
into
six
groups
of
each.
Groups
A
B
served
as
normal
negative
controls,
respectively.
Group
C,
the
standard
control,
administered
300
mg/kg
body
weight
(bw)
Omega
3
for
27
days,
followed
by
100
bw
cyclophosphamide
day
28.
D,
E,
F
received
5,
2.5,
1.5
ml/kg
b.w.
CMSO
then
measured
weights
experimental
every
week.
Rats
all
were
sacrificed
30
collected
blood
biochemical
analysis
using
methods.
phytochemical
constituents
determined
spectrophotometric
method.
indicated
relative
composition
constituents(mg/100g)
phenols
(30%),
tannins
(20%),
flavonoids
(18%),
terpenoids
(15%),
glycosides
(10%),
alkaloids
(5%),
HCN
(2%)
in
Cucumeropsis
oil.
When
given
albino
rats,
it
greatly
decreased
activities
catalase
(CAT)
superoxide
dismutase
(SOD),
but
increased
iNOS
levels
MDA
IL-1β.
Cyclophosphamide
ALT
(52.3
U/L),
AST
(48.7
ALP
(46.5
total
bilirubin
(1.4
mg/dL),
conjugated
(0.8
creatinine
urea
(45.6
BUN
(15.7
with
a
reduction
albumin
(4.8
g/dL)
level.
administration
also
caused
hepatocellular
necrosis,
inflammatory
leukocyte
infiltration,
tubular
proteinaceous
deposits
Bowman's
space
kidney.
However,
combining
oils
significantly
restored
altered
histology
architecture,
antioxidant,
markers,
liver
kidney
function
parameters
comparable
group,
thereby
reducing
harmful
effects
cyclophosphamide.
effect
did
not
depend
dose.
These
results
suggest
that
CMSO,
being
an
anti-inflammatory,
potentially
aid
preventing
treating
toxicity
resulting
Quality in Sport,
Год журнала:
2025,
Номер
37, С. 57434 - 57434
Опубликована: Янв. 15, 2025
Background:
The
increasing
popularity
of
ultra-endurance
sports
emphasizes
the
need
for
a
deeper
understanding
their
health
implications,
particularly
impact
on
kidney
function.
Given
kidneys’
crucial
role
in
waste
filtration,
fluid
and
electrolyte
balance,
close
connection
to
physiological
demands
intense
physical
activity,
it
requires
detailed
investigation
from
this
perspective.
Purpose:
objective
study
is
present
current
state
knowledge
topic
function
context
sports.
It
examines
risk
factors,
underlying
mechanisms,
potential
strategies
preventing
renal
injuries
associated
with
these
specific
types
activities.
Findings:
Ultra-endurance
significant
risks
health,
including
acute
injury
(AKI)
estimated
affect
approximately
40%
participants,
rhabdomyolysis
dehydration,
which
are
often
compounded
by
additional
factors
such
as
gastrointestinal
distress
use
non-steroidal
anti-inflammatory
drugs
(NSAIDs).
There
improved
diagnostic
criteria
detect
population,
novel
biomarkers
neutrophil
gelatinase-associated
lipocalin
(NGAL),
molecule-1
(KIM-1),
cystatin
C
showing
promise.
A
multifaceted
preventive
approach
mandatory
pre-event
screening,
personal
monitoring
devices,
proper
hydration
nutrition,
adequate
race
preparation,
avoidance
NSAIDs
mitigate
maintain
athletes.
Current Hypertension Reports,
Год журнала:
2025,
Номер
27(1)
Опубликована: Фев. 21, 2025
Abstract
Purpose
of
Review
The
growing
burden
cardiovascular
diseases
has
become
a
significant
concern
in
both
adult
and
youth
populations.
Urinary
biomarkers
kidney
function
could
provide
useful
insights
that
may
aid
the
early
identification
individuals
at
higher
risk
adverse
outcomes.
This
systematic
review
aimed
to
assess
associations
between
urinary
different
measures
health.
Recent
Findings
PubMed,
Scopus,
EBSCOhost
were
searched
for
articles
published
January
2018
December
2023.
Studies
exploring
(alpha-1
microglobulin
(uA1M),
neutrophil
gelatinase-associated
lipocalin
(uNGAL),
uromodulin
(uUMOD)
CKD273
classifier)
health
(blood
pressure
markers
target
organ
damage)
included.
We
identified
1186
articles,
with
22
studies
eligible
inclusion.
Among
12
reporting
uA1M
health,
six
indicated
positive
office
blood
three
observed
damage.
Out
nine
explored
link
uUMOD
parameters,
four
found
negative
pressure.
With
regard
uNGAL,
only
two
out
seven
analysed
reported
varying
pressure,
while
neither
focusing
on
any
statistically
results.
Summary
Biomarkers
tubule
function,
represented
by
uUMOD,
are
relevant
setting
should
be
assessed
utilisation
clinical
practice
identify
outcomes
an
stage
allowing
timely
intervention.
Graphical
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 14, 2025
Kidney
stones
are
a
major
public
health
concern,
and
their
prevalence
has
increased
significantly
in
recent
decades.
While
urinary
albumin-to-creatinine
ratio
(UACR)
is
recognized
marker
for
kidney
disease,
its
relationship
with
stones,
especially
within
the
normal
UACR
range,
remains
unclear.
The
purpose
of
this
study
was
to
investigate
association
between
levels
range
risk
developing
stones.
We
analyzed
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
conducted
2009
2018,
focusing
on
adults
aged
20
years
older
available
data.
Using
weighted
multivariable
logistic
regression
restricted
cubic
spline
(RCS)
models,
we
assessed
adjusting
relevant
covariates.
Subgroup
analyses
were
also
performed
evaluate
consistency
across
demographic
health-related
factors.
found
that
higher
associated
an
likelihood
Specifically,
individuals
highest
quartile
had
36%
odds
compared
those
lowest
(OR:
1.36,
95%
CI:
1.04-1.77).
A
non-linear,
dose-response
observed
stone
(P
<
0.001),
remaining
consistent
various
subgroups.
Elevated
levels,
even
strongly
This
finding
highlights
potential
as
valuable
biomarker
assessing
clinical
practice.
Metabolism and Target Organ Damage,
Год журнала:
2025,
Номер
5(1)
Опубликована: Март 21, 2025
With
the
backset
of
epidemic
surge
type
2
diabetes
(T2D),
obesity,
and
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
key
role
jejunal
mucosa
in
development
disorders,
beyond
its
normal
function
nutrient
absorption,
has
become
increasingly
appreciated.
In
humans,
compared
to
non-diabetic
controls,
diabetic
patients
have
hypertrophy,
hyperplasia
enteroendocrine
cells,
increased
numbers
cells
enterocytes.
Moreover,
functional
changes
also
been
observed,
including
variations
glucose
transporters,
enteric
nerves,
intestinal
microbiota
composition.
Duodenal
resurfacing
(DMR)
starts
with
assumption
that
mucosal
interface
will
reset
correct
any
abnormal
signaling
from
duodenal
will,
therefore,
result
improved
pancreatic
endocrine
tolerance
owing
restored
surface.
The
endoscopic
technique
DMR
involves
hydrothermal
ablation
more
superficial
layers.
Data
reviewed
indicate
is
a
safe
well-tolerated
procedure,
favorable
outcomes
on
homeostasis
among
those
T2D,
body
weight
tests
MASLD.
Additional
studies
are
therefore
urgently
needed
ascertain,
various
surgical,
medical
choices,
best
precision
medicine
option
fit
individual
patient
