Internal Medicine Journal,
Год журнала:
2024,
Номер
54(7), С. 1056 - 1065
Опубликована: Июнь 5, 2024
Normal-anion-gap
metabolic
acidosis
(NAGMA)
is
a
common
but
often
under-recognised
and
poorly
understood
condition,
especially
by
less-experienced
clinicians.
In
adults,
NAGMA
might
be
an
initial
clue
to
more
significant
underlying
pathology,
such
as
autoimmune
diseases,
hypergammaglobulinemia
or
drug
toxicities.
However,
identifying
the
aetiology
can
challenging
due
diverse
processes
involved
in
development
of
acidosis.
A
better
understanding
pathophysiology
help
treating
physicians
suspect
evaluate
condition
early
reach
correct
diagnosis.
This
article
provides
overview
renal
acid-base
regulation,
discusses
pathophysiological
developing
framework
for
evaluation
accurate
The Journal of Basic and Applied Zoology,
Год журнала:
2025,
Номер
86(1)
Опубликована: Май 19, 2025
Abstract
Background
Fipronil
is
a
new,
broad-spectrum
phenylpyrazole
pesticide
used
in
agriculture
veterinary
medicine
to
control
insects,
fleas
and
ticks.
The
excessive
use
of
fipronil,
due
its
prolonged
half-life
bioaccumulation
properties,
poses
potential
environmental,
human
animal
risks.
P-coumaric
acid
natural
dietary
polyphenolic
compound
with
antioxidant
anti-inflammatory
properties.
present
study
aimed
investigate
the
ameliorative
effect
p-coumaric
on
fipronil-induced
acute
kidney
injury.
mice
were
divided
into
three
groups
(vehicle/control,
fipronil
challenged
@
25
mg/kg
bodyweight
bwt
+
acid-treated
100
groups).
Hematological,
function
biomarkers,
oxidative
stress
parameters
like
lipid
peroxidation,
superoxide
dismutase
catalase,
gene
expression
NF-κβ2
histopathology
studied.
Results
administration
caused
significant
increase
blood
urea
nitrogen
creatinine.
A
stress,
as
well
downregulation
enzymes
along
histopathological
changes
such
degeneration,
necrosis
tubular
epithelial
cells,
atrophied
renal
corpuscles
mononuclear
infiltration
observed
administration.
Administration
against
decreased
serum
biomarkers
NF-κβ2,
improved
enzyme
levels
mitigated
structural
induced
by
fipronil.
Conclusion
Thus
ameliorates
injury
through
attenuation
changes,
inflammation
restoration
levels.
Transporter
research
primarily
relies
on
the
canonical
substrates
of
well-established
transporters.
This
approach
has
limitations
when
studying
transporters
for
low-abundant
micromolecules,
such
as
micronutrients,
and
may
not
reveal
physiological
functions
While
d
-serine,
a
trace
enantiomer
serine
in
circulation,
was
discovered
an
emerging
biomarker
kidney
function,
its
transport
mechanisms
periphery
remain
unknown.
Here,
using
multi-hierarchical
from
body
fluids
to
molecules,
combining
multi-omics,
cell-free
synthetic
biochemistry,
ex
vivo
analyses,
we
have
identified
two
types
renal
-serine
systems.
We
revealed
that
small
amino
acid
transporter
ASCT2
serves
previously
uncharacterized
non-canonical
substrate
sodium-coupled
monocarboxylate
(SMCTs).
These
systems
are
physiologically
complementary,
but
dominates
role
pathological
condition.
Our
findings
only
shed
light
transport,
also
clarify
importance
transport.
study
provides
framework
investigating
multiple
various
micromolecules
under
conditions
multifactorial
diseases.
Journal of Complexity in Health Sciences,
Год журнала:
2024,
Номер
7(1), С. 1 - 18
Опубликована: Май 23, 2024
The
aim
of
the
study
was
to
evaluate
interconnections
between
local
Schumann
resonances
Earth’s
magnetic
field
and
episodes
kidney
disease.
Materials
Methods:
Study
participants
included
716
males
624
females
who
had
disease
during
period
1
January
2021
31
December
attended
Department
Nephrology
at
Hospital
Lithuanian
University
Health
Sciences,
Kauno
klinikos.
Time
varying
data
collected
magnetometer
site
located
in
Lithuania.
Results
Conclusions:
results
support
hypothesis
that
has
a
relationship
number
nephrology
patient
hospitalizations
per
week
average
weekly
strength
different
frequency
ranges.
Working
hypotheses
are
proposed
for
mechanisms
influence
electromagnetic
on
function:
а)
quantum
mechanical
features
atomic
composition
renal
tissue
molecules
determine
kidney-specific
reaction;
b)
cyclotron
resonance
mechanism;
c)
resonant
response
cells
morphological
structures
external
bioactive
frequencies
range
6-8
Hz;
d)
mechanism
indirect
blood
as
magnetically
saturated
medium.
Internal Medicine Journal,
Год журнала:
2024,
Номер
54(7), С. 1056 - 1065
Опубликована: Июнь 5, 2024
Normal-anion-gap
metabolic
acidosis
(NAGMA)
is
a
common
but
often
under-recognised
and
poorly
understood
condition,
especially
by
less-experienced
clinicians.
In
adults,
NAGMA
might
be
an
initial
clue
to
more
significant
underlying
pathology,
such
as
autoimmune
diseases,
hypergammaglobulinemia
or
drug
toxicities.
However,
identifying
the
aetiology
can
challenging
due
diverse
processes
involved
in
development
of
acidosis.
A
better
understanding
pathophysiology
help
treating
physicians
suspect
evaluate
condition
early
reach
correct
diagnosis.
This
article
provides
overview
renal
acid-base
regulation,
discusses
pathophysiological
developing
framework
for
evaluation
accurate
