IQOS - new heat-not-burn tobacco products and its impact on health DOI Creative Commons
Krzysztof Jachowicz, Krzysztof Feja, Ewa Barbara Łuczak

и другие.

Journal of Education Health and Sport, Год журнала: 2023, Номер 46(1), С. 11 - 21

Опубликована: Авг. 25, 2023

Introduction: Iqos and other heat-not-burn products according to tobacco companies are a safer alternative cigarettes. The aim of this article is objectively review the potential impact iQOS® on human health by searching for integrating published research findings. This provides comprehensive analysis scientific conducted effects use health, distinguishing between specific medical fields. Materials methods: study based articles collected from PubMed database spanning years 2016-2023. was through keywords such as "Iqos", "Heat not burn", "Iqos impact". Results: Tobacco heaters seen potentially less harmful. However, emerging their harmfulness clearly shows that despite reduced concentrations compounds hazardous aerosol produced still contains same harmful substances. Further studies show toxic at similar level smoke traditional cigarettes.

Язык: Английский

The Hidden Dangers: E-Cigarettes, Heated Tobacco, and Their Impact on Oxidative Stress and Atherosclerosis—A Systematic Review and Narrative Synthesis of the Evidence DOI Creative Commons

Arianna Magna,

Nausica Polisena,

Ludovica Polisena

и другие.

Antioxidants, Год журнала: 2024, Номер 13(11), С. 1395 - 1395

Опубликована: Ноя. 15, 2024

Electronic cigarettes and heated tobacco products have seen significant growth in sales usage recent years. Initially promoted as potentially less harmful alternatives to traditional tobacco, scientific evidence has raised serious concerns about the risks they pose, particularly relation atherosclerosis. While atherosclerosis long been associated with conventional smoking, emerging research suggests that electronic may also contribute development of this condition related cardiovascular complications. In a narrative review, we examined potential effects on oxidative stress Several studies shown e-cigarettes increase through activation enzymes such NADPH oxidase. One primary these is their pro-thrombotic pro-atherosclerotic impact endothelial cells platelets, which promotes inflammatory processes within arteries. Furthermore, chemicals found cigarette liquids exacerbate inflammation cause dysfunction. systematic analyzed chronic exposure function, assessed by brachial flow-mediated dilation (FMD). Although are often perceived safer could still present health. It essential raise public awareness dangers implement protective measures, for young people.

Язык: Английский

Процитировано

2
GPS2 ameliorates cigarette smoking-induced pulmonary vascular remodeling by modulating the ras-Raf-ERK axis DOI Creative Commons
Ting Hu,

Chaohui Mu,

Yanmiao Li

и другие.

Respiratory Research, Год журнала: 2024, Номер 25(1)

Опубликована: Май 16, 2024

Mitogen-activated protein kinase (MAPK)signaling-mediated smoking-associated pulmonary vascular remodeling (PVR) plays an important role in the pathogenesis of group 3 hypertension (PH). And G pathway suppressor 2 (GPS2) could suppress G-protein signaling such as Ras and MAPK, but its cigarette smoking -induced PVR (CS-PVR) is unclear. An vivo model smoke-exposed rats was constructed to assess GPS2 smoking-induced PH PVR. In vitro, effects overexpression silencing on function human arterial smooth cells (HPASMCs) underlying mechanisms were explored. expression downregulated rat arteries (PAs) HPASMCs after CS exposure. More importantly, CS-exposed with had lower right ventricular systolic pressure (RVSP), hypertrophy index (RVHI), wall thickness (WT%) than those without. enhanced proliferation migration induced by extract (CSE) can be evidently inhibited overexpressed GPS2. Besides, GPS2siRNA significantly proliferation, well activated Raf/ERK signaling, while these zoledronic acid (ZOL). addition, promoter methylation level PAs increased exposure, 5-aza-2-deoxycytidine (5-aza) CSE-induced hypermethylation downregulation vitro. improve CS-PVR, suggesting that might serve a novel therapeutic target for PH-COPD future.

Язык: Английский

Процитировано

1
Association Between Serine Concentration and Coronary Heart Disease: A Case–Control Study DOI Creative Commons
Fangfang Fan, Zhe Liang, Zhihao Liu

и другие.

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 2955 - 2965

Опубликована: Июль 1, 2024

Purpose: Early identification of new residual risk factors for coronary heart disease (CHD) is warranted. In this study, we aim to investigate the association between serine concentration, an important amino acid in one-carbon metabolism, and CHD Chinese hospitalized patients. Patients Methods: This case–control study included 428 pairs comprising patients with a maximum artery stenosis degree > 70% controls < 30%. The individuals were matched by age, sex, date angiography at Peking University First Hospital from January 1, 2016, December 31, 2019. Conditional logistic regression was used associations concentration CHD. Results: aged 63.48 ± 10.38 years, 43.73% male. Compared controls, had slightly lower (13.35 4.20 vs 13.77 4.08 μg/mL), but difference not significant. multivariable conditional analysis, every 1 μg/mL increase odds decreased 6% (95% confidence interval [CI] 0.90– 0.99; P = 0.010). ≥ 13.41 than those (odds ratio [OR] 0.57, 95% CI 0.39– 0.84; 0.004). Subgroup analyses showed that sex interacted relationship ( interaction 0.039), which more significant males (OR 0.93, 0.87– 0.98; 0.013) females. Conclusion: observed inverse prevalence patients, revealed might play protective role Keywords: serine, disease, case–control, metabolism

Язык: Английский

Процитировано

1
Materials for the selective removal of toxic compounds in cigarette smoke: A review DOI
Haiying Wei,

Jinsheng Rui,

Min You

и другие.

Separation and Purification Technology, Год журнала: 2024, Номер 354, С. 128908 - 128908

Опубликована: Июль 21, 2024

Язык: Английский

Процитировано

1
Identification of potential hub genes and regulatory networks of smoking-related endothelial dysfunction in atherosclerosis using bioinformatics analysis DOI
Julong Guo,

Yachan Ning,

Dikang Pan

и другие.

Technology and Health Care, Год журнала: 2023, Номер 32(3), С. 1781 - 1794

Опубликована: Дек. 6, 2023

BACKGROUND: Endothelial dysfunction, the earliest stage of atherosclerosis, can be caused by smoking, but its molecular mechanism requires further investigation. OBJECTIVE: This study aimed to use bioinformatics analysis identify potential mechanisms involved in smoking-related atherosclerotic endothelial dysfunction. METHODS: The transcriptome data used for this were obtained from Gene Expression Omnibus (GEO) database. GSE137578 and GSE141136 datasets common differentially expressed genes (co-DEGs) cells treated with oxidized low-density lipoprotein (ox-LDL) tobacco. co-DEGs annotated using Ontology (GO) Kyoto Encyclopedia Genes Genomics (KEGG) databases. Additionally, a protein-protein interaction (PPI) network was constructed visualize their interactions screen hub genes. GSE120521 dataset verify expression unstable plaques. miRNA profile GSE137580 online databases (starBase 2.0, TargetScan 8.0 DGIdb v4.2.0) predict related non-coding RNAs drugs. RESULTS: A total 232 identified, including 113 up-regulated 119 down-regulated These DEGs primarily enriched detrimental autophagy, cell death, transcription factors, cytokines, implicated ferroptosis, abnormal lipid metabolism, inflammation, oxidative stress pathways. Ten screened PPI network, such as FOS, HMOX1, SQSTM1, PTGS2, ATF3, DDIT3, MCM4, KIF15, UHRF1, CCL2. Importantly, HMOX1 plaques (p= 0.034). Finally, regulatory involving lncRNA/circRNA-miRNA-hub drug-hub established. CONCLUSION: Atherosclerotic dysfunction is associated smoking-induced injury. Through analysis, we identified provided therapeutic targets.

Язык: Английский

Процитировано

3
Acute effects of traditional and electronic cigarettes on palatal blood flow in smokers: A cross-over pilot study DOI Creative Commons
Orsolya Vámos, Norbert Kulcsár, Barbara Mikecs

и другие.

Journal of Oral Biology and Craniofacial Research, Год журнала: 2024, Номер 14(2), С. 152 - 157

Опубликована: Фев. 5, 2024

Smoking is a significant health hazard and contributes to cardiovascular pulmonary diseases. It can increase postoperative complications during oral maxillofacial surgery due its topical effect on the mucosa. New alternatives traditional tobacco products are gaining popularity, in particular, electronic cigarettes. This pilot study investigated acute effects of nicotine-containing nicotine-free cigarettes palatal blood flow (PBF), compared their 14 medically healthy volunteers (8 males, 6 females, age: 34.7 ± 7.0) were recruited for study. All patients (N = 14) requested smoke (ECN) (EC0) mouthpiece (end cigarette) as control sham smoking blind test (BT). EC users did not cigarette (TC), resulting 10 people TC group. Palatal was measured by Laser Speckle Contrast Imager before, immediately after, 15 min after exposures. Exhaled carbon monoxide (eCO) carboxyhemoglobin (COHb) before with piCO+ Smokerlyzer machine. In all groups, no differences observed changes between time points. significantly higher (TC) group both exposure (p < 0.05). Acute use either or may have minimal impact flow, but additional studies required clarify

Язык: Английский

Процитировано

0
Modifiable lifestyle factors and risk of intracranial aneurysm: A univariate and multivariate Mendelian randomisation study DOI

Jiacong Tan,

Huaxin Zhu,

Yanyang Zeng

и другие.

Neuroscience, Год журнала: 2024, Номер 566, С. 9 - 16

Опубликована: Дек. 19, 2024

Язык: Английский

Процитировано

0
Incidence, impact and predictors of residual device patency after left atrial appendage closure with the LACbes device DOI
Peng‐Cheng Yao,

Zhen-Tao Fei,

Mu Chen

и другие.

International Journal of Cardiology, Год журнала: 2023, Номер 397, С. 131640 - 131640

Опубликована: Дек. 6, 2023

Язык: Английский

Процитировано

1
Editorial: Special issue: “Impact of lifestyle und behavioral risk factors on endothelial function and vascular biology”—how lifestyle and behavioral risk factors affect the vasculature DOI Creative Commons
Andreas Daiber, Omar Hahad,

Thomas Münzel

и другие.

Pflügers Archiv - European Journal of Physiology, Год журнала: 2023, Номер 475(7), С. 777 - 781

Опубликована: Июнь 4, 2023

Язык: Английский

Процитировано

0
Smoke on the blood stream: novel insights in cigarette smoke-induced atherosclerosis and plaque erosion DOI
Henning Morawietz

Cardiovascular Research, Год журнала: 2023, Номер 119(9), С. 1781 - 1783

Опубликована: Июнь 30, 2023

Journal Article Smoke on the blood stream: novel insights in cigarette smoke-induced atherosclerosis and plaque erosion Get access Henning Morawietz Division of Vascular Endothelium Microcirculation, Department Medicine III, Faculty University Hospital Carl Gustav Carus, TUD Dresden Technology, Fetscherstr. 74, D-01307 Dresden, Germany Corresponding author. Tel: +49 351 458 6625; fax: 6354, E-mail: [email protected] https://orcid.org/0000-0001-9360-9736 Search for other works by this author on: Oxford Academic PubMed Google Scholar Cardiovascular Research, Volume 119, Issue 9, July 2023, Pages 1781–1783, https://doi.org/10.1093/cvr/cvad097 Published: 01 2023 history Corrected typeset: 04

Язык: Английский

Процитировано

0